Protein Alignment SMC2 and smc-6

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_496476.2
• Gene: smc-6 / 174776
• WormBaseID: WBGene00010056
• Length: 1149
• Species: Caenorhabditis elegans
• Alignment Length: 1254
• Identity: 257/1254 - (20%)
• Similarity: 484/1254 - (38%)
• Gaps: 325/1254 - (25%)

  Fly    30 ITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAGITKATVTIVFDNTNPAQCPQG 94
            |.|.||||||.:..:|...||.....|.|.:.::..:    :.|.|::.:||...|......|..
 Worm    75 IGGPNGSGKSALFAAINLGLGGRGSDNDRGNTVKSYI----KDGTTQSKITITLTNAGLNAHPDF 135

  Fly    95 YEKCREISVTRQVVVGGKNKFLINGK----------LVQNKK--VQDFFCSIQLNVNNPNFLIMQ 147
            .:.   ||:.|.:........:.:.|          :|..||  |........::::||.|.:.|
 Worm   136 DDL---ISIERTINQASSTYIMKSVKVTSSDNHVERIVSRKKADVDRIVSRFSIHLSNPAFWMSQ 197

  Fly   148 GKIQQVL-NMKPKEVLSMVEEAAGTS-------QYKTKRDATKTLIEKKETKV--RETKVLLDEE 202
            .:.:..| |.||..|..:..|:....       ::....|....||:.|..::  .:.|:...:|
 Worm   198 DRSRSFLANFKPANVYKLYLESTNLENIRLSYIRFADALDECFALIQLKAGEILNEQKKLKRMQE 262

  Fly   203 VLPKLVKLRQERSAYQEY---QKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCK 264
            ......||.|:|:....:   ...|:..|:..:|.::   ||:.|..||:: :|.|.|
 Worm   263 QRDLQAKLDQDRALVASFCWKLLFCKVRDYNDQIELT---LKKQEAQKTLQ-DETKKE------- 316

  Fly   265 ATHAKNLAEVESIENSVKEMQQQI---DAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQ 326
              :|||.|....:|..::|.:.::   |||:..:.::|:.:  .::.||         .:..|::
 Worm   317 --YAKNRAARTEVEKKIQEFRDEVEVQDAEIAEAREDLDAK--KRKVLE---------FEEKIRE 368

  Fly   327 DEKKIRMASKNIEDDERAL--AKKEAD-MAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLS 388
            .|:.||..:...:..||.:  ||.|.. :.:.||. :.|.:...:....|:|..::.|.:..|
 Worm   369 CEQSIRKKTSEKKYMERTIVNAKNEVRILLEKQGN-QDLTKRLTKVENDYKDISQQRENMELG-- 430

  Fly   389 TNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQ 453
                ||::.|:|:|......:...:....|.:.::...|..::| :.||.....|..||
 Worm   431 ----GESAKLREKLDTVITDYKRKEEEKYTIQRDINQLRRKIEQ-DMETMRRSRATKKD------ 484

  Fly   454 LVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRR 518
                         :::..|.|.              .::..|::| :.||:            :.
 Worm   485 -------------AINKFGSHM--------------AEILMEINR-SKSRF------------QT 509

  Fly   519 KVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTS---KKILQ--RGNLQRRVTLIPINK 578
            ..:|.:||...:.|.:.:..:.:..|....:::....:.:   :.|.|  |...|.|.|:| :.|
 Worm   510 VPKGPLGKYITLIDPKWAFTVEECIGNLANNFLCSSHLDAEILRNIFQSLRIPAQDRPTII-VAK 573

  Fly   579 IQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQI---SYD 640
            . :|....|:.|.:.:   .:::...:...|.|.:...:.|......::.:|...|.::   :|.
 Worm   574 C-NGRAYTNLHEPSSD---FKSIYRVLKFSDPDVHNVIIDKSNCEQFILIEDKTEAMELMGSNYP 634

  Fly   641 PRINCRSVTLEGDVVDPHGTVS--------GGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVE 697
            |:...::.||:|.....:|..|        ||            ||......:..::|.  ..:.
 Worm   635 PQNAVKAYTLDGSQAYANGPNSQYRFYSGRGG------------HARGTFGNDQGDVDE--GALA 685

  Fly   698 KQIASIENQALAFNKMKENLDLRQ--HELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDS 760
            :.|...:::|:..    |..|||:  |||.:..|...||     :|.|:|...::..|.     |
 Worm   686 RLIEDTKSEAMRL----ETQDLRKQDHELKVIYNERDQT-----KAAIDEFDRKLSNLR-----S 736

  Fly   761 REKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEIT 825
            :|.||..|||  |:.|:||..                          ||    |.:.|.|...|.
 Worm   737 QELQKERQAK--DLRAELAQT--------------------------AN----EDQVENLNESIE 769

  Fly   826 ELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRD---QNKEM 887
            |:||.|...:.:.::::.|:....|::       :....|..|.|..:.|.:.:.||   :::::
 Worm   770 EMQKKIPLIEDEVKDILKNVADITADM-------APVIQERKEAEHTLAEIQKETRDFASKSQKL 827

  Fly   888 RNQLVKKE---KMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMK 949
            :|:|.|.:   ::||    |.|: |.|.:|.....::||...:|.:|:|    .:..:|     |
 Worm   828 QNELSKYDDAGEILK----IRLD-KVKADEGVFFHTEAKLKSERDDAME----MVENDK-----K 878

  Fly   950 NTRYDYSKEDP---------HEAGNKLAKMQEKKDK----MERTLNMNAIMVLDREEENFKETER 1001
            |......:.||         .||..|:.:||:..|:    .:.|:.:..:       ::||
 Worm   879 NHPMPPGETDPPDLSSFPSTTEAQRKIEEMQKAVDRATVGCDTTITLECV-------KDFK---- 932

  Fly  1002 RRNIVAMDKEKIKKIIVKMDEEEQDQLN-------------KAATE------------VNTNFSG 1041
                   ||.|..|.:.:|.|:...:|.             |..||            |..:|.|
 Worm   933 -------DKLKRLKYLCRMIEDVLIELKNLHAARVKAYPSLKKFTELKVCNKFQELLAVRGHFIG 990

  Fly  1042 --------------IFSSLLPGAEAKLNP---------VHT----NGCLTGLEIKVGFNGIWKE- 1078
                          :.||....|.|...|         .|:    :...||...|.......|:
 Worm   991 GLEFDHEKETLNVNVQSSKEKDAMAGRRPEVLEVEEVDEHSYDDDSDDSTGPRRKKSKKSGQKKK 1055

  Fly  1079 ---SLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSML----KQHFTNS 1136
               .|..||||::|.|..:||:::.:....|..::||.|..:||.:.:.:..:|    .:.|.::
 Worm  1056 RVRDLKGLSGGERSFVTAALVMSLWEVMEQPFRMMDEFDVFMDMMNRKLVMDLLVELATKKFPHN 1120

  Fly  1137 QFLI--------VSLKDGL 1147
            ||:.        :::.|||
 Worm  1121 QFIFFTPQGIKELNMVDGL 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	257/1254 (20%)
smc-6	NP_496476.2	P-loop containing Nucleoside Triphosphate Hydrolases	47..>206	CDD:476819	32/137 (23%)
		SMC_prok_B	227..>869	CDD:274008	159/796 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1056..1148	CDD:476819	22/84 (26%)