Protein Alignment SMC2 and him-1

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001040658.2
• Gene: him-1 / 172116
• WormBaseID: WBGene00001860
• Length: 1262
• Species: Caenorhabditis elegans
• Alignment Length: 1302
• Identity: 280/1302 - (21%)
• Similarity: 550/1302 - (42%)
• Gaps: 253/1302 - (19%)

  Fly     6 LVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNG 70
            |.::.||||..:..|..| ..||||.|.|||||||::|:|.|||| ....::|.....||::
 Worm    19 LEIENFKSYKGKHTIGPF-TRFTAIIGPNGSGKSNLMDAISFVLG-EKPSSLRVRKYADLIH--- 78

  Fly    71 QAGITKATVTIVFDNTNPAQCPQGYEKCR----------EISVTRQVVVGGKNKFLINGKLVQNK 125
            .|.|.|...                :|||          ::....:.|..|.::.|::|:.|.:.
 Worm    79 GAPINKPVA----------------KKCRVTMNYKYSDGKVKAFTRGVNNGTSEHLLDGQTVTSA 127

  Fly   126 KVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKET 190
            .......||.:.:...|||:.||.|:.:....|||...:.||.:.:.:::.:.:..|..:.|.|.
 Worm   128 AYSQEMESINIFIKARNFLVYQGAIENIAMKTPKERTQLFEELSRSHEFQAEYERLKVEMTKAED 192

  Fly   191 KVRETKVLLDEE--VLPKLVKLRQERSAYQEYQKICRDI---DFLIRIHISAKYLKQCETLKTVE 250
               :|:..:::.  :..:..:.:.|:...::||.:..::   ..::.:|    .|..||  :|::
 Worm   193 ---DTQHNMNKRRGIAQEKREAKMEKDEAEKYQTMKNELAAKSTMLFLH----QLFHCE--RTID 248

  Fly   251 ANEHKI---EDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEAT 312
            .::.:|   :..||:.:||.:|..|::.::....::..:::. :|...:...||.|:.|:....|
 Worm   249 ESKEEINAQKKTIASLEATRSKEEAKIAAVHQEHRKALREVQ-KMTRKLDQKETDLAEKQQNMLT 312

  Fly   313 ATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKE------ADMAKVQGEFESLK---EADAR 368
                ||.   ::..:.||:.:|.|.:...|   :|.|      ||:.|.:.|.|..|   ||:.:
 Worm   313 ----LKV---SVAHEHKKLEIAKKMLAAAE---SKAENNSTQLADLKKSKKELEKKKAAYEAEIQ 367

  Fly   369 DSKAYEDAQKKLEAVSQ--GLSTNENGEASTLQEQLIVAKEQF--------------SEAQTTIK 417
            |.....:.....|.|.:  .|......|::.:|.:|::|::.|              .|.|..:|
 Worm   368 DMMQRGELNLSDEQVREYGQLKDQAQRESAMVQRELLMAEQVFEGDKSSLNHELRRQKEHQERVK 432

  Fly   418 TSEIELRHTR---GVLKQREGETQTNDAAYVKD-KKLHDQLVV----------EIKNLERQLQSL 468
            ..|.::|...   ..|.||..||:........| ||:.:.:|:          |:..:.|||...
 Worm   433 AKEGDVRRIETQIATLAQRIKETEEETKILKADLKKIENDVVIDKSAAAEYNKELVAVVRQLSEA 497

  Fly   469 DYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKDM 533
            ..:....|:.::|...|...|::.                  ||      .|.|.:..|.|....
 Worm   498 SGDSAEGERNQRRTEALEGLKKNF------------------PE------SVYGRLVDLCQPSHK 538

  Fly   534 QNSMALVQTAGGSLYSYVTDDDVTSKK--ILQRGNLQRRVTLIPINKIQSGSLNRNVVEYAQNKV 596
            :.::|..:.....:.|.|.|.:.|:.|  :..:.:.....|.:|.:.:....||..:.|..:
 Worm   539 RFNIATTKILQKHMNSIVCDTEETAAKAIVYLKDHRYPPETFLPNDALVVNPLNEKLREIKK--- 600

  Fly   597 GAENVQWAMSLID-YDRYYEPVMKFCFGGTLICKDLIVAKQISY---DPRINCRSVTLEGDVVDP 657
             ...|:....:|: ..:.....::|..|..|:|:....|||::|   :.:...::|:::|.:...
 Worm   601 -PAGVKLVFDVINPQHQAARKALQFVCGNALVCESQEDAKQLAYGGGELKDRFKAVSMDGTLFQQ 664

  Fly   658 HGTVSGGAA---PKGANVLEELHAIKQIEKEYREIDSEIAQVEK------QIASIEN------QA 707
            .|.:|||:|   .|.....|::  :||:.::..:::.:||.::|      ::.|:.:      |.
 Worm   665 SGVMSGGSADLRQKSKKWDEKV--VKQLREKRNQLNEKIADLQKHRRRELEVESVRSKINGNEQR 727

  Fly   708 LAFNKMKENL-DLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKI 771
            ||.  ||.:| ::|:.:|...:|.|...|     ||:..:..|:...::::..|....|:.|.|.
 Worm   728 LAM--MKRDLKNMREMQLERLQNELEGMT-----AEMNMLPPRISNCQEKLERSESTLKSLQTKS 785

  Fly   772 VDIEAK----------LADAKGYRERE----------LNAATNEIK--------VTKQRAEKSRA 808
            .::..:          :|..:.|..||          |.:..::|:        ||:|...:...
 Worm   786 NEVADRIFADFCTRVGIASIRDYENREMRIKQEMEDKLRSFDDDIQKLAYEIDFVTEQDGNRKVE 850

  Fly   809 NWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQA- 872
            ..|::..:.:....::.:.:|:...|.|:|.|.::..::...|..||.....:..:||.::.|.
 Worm   851 VEKEKVSQIDRQYKDMKKKEKTAAAALKEHTESMEQDKEVLEEKKALSHKLETEWNEVKKIAQVA 915

  Fly   873 ----IKEQKDKLR-----DQNKEMRNQLVKKEKM------LKENQEIELEVKKKENEQKKISSD- 921
                .|.:|:.||     .:.:..|:.|:...|:      ||.....::|.::.:.:.....|.
 Worm   916 MKDFTKAEKELLRLESLLTKKQYERHSLLHSVKLGQIALPLKSGSMADVEYEEDDGDDTASQSSQ 980

  Fly   922 --------AKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKED-PHEAGNKL----AKMQEK 973
                    ::|..:|.:.::..|..:|.|..         |...:| ..:..|:|    .::|:.
 Worm   981 SATDGPSVSEEQIQREQHIKINYDSLPREYK---------DVDDDDGVRQMSNRLNVEIDELQKN 1036

  Fly   974 KDKMER-TLNMNAIM--VLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEV 1035
            ..||.. .|..|..|  |.:||.|:.:|.|..|......:::.:|:........||..:..|..:
 Worm  1037 VSKMNAPNLKANQRMAEVKEREAESTEELENARKKAKRIRQQFEKVKTDRYRRFQDFFDPVANTI 1101

  Fly  1036 ---------NTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGELSGGQKSLV 1091
                     ||:.....     ||:....|.     |.|::......|.....:..||||:|::.
 Worm  1102 DDIYKQLSRNTSAQAFL-----GADNMEEPY-----LDGIQYNCVAPGKRFRPMDNLSGGEKTIA 1156

  Fly  1092 ALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSML----KQHFTNSQFLIVSLKDGLFNHAN 1152
            ||:|:.|:...:|||.::|||:|||||.::...:.|.:    ::|.   |.:::|||:..:|.|:
 Worm  1157 ALALLFAVHGRNPAPFFVLDEIDAALDNTNIGKVASYICESAREHM---QIIVISLKEEFYNKAD 1218

  Fly  1153 VL 1154
            .|
 Worm  1219 SL 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	280/1302 (22%)
him-1	NP_001040658.2	SMC_N	15..1232	CDD:426784	280/1302 (22%)