Protein Alignment SMC2 and Smc2

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_032043.3
• Gene: Smc2 / 14211
• MGIID: 106067
• Length: 1191
• Species: Mus musculus
• Alignment Length: 1186
• Identity: 501/1186 - (42%)
• Similarity: 768/1186 - (64%)
• Gaps: 22/1186 - (1%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            ||||.::|:|||||.:|||:.||||.|.|||||||||||||||||||:||||||..||||.||||
Mouse     1 MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            ||||||||||||:|:|.|||::..|.|.|:|...||:||||||:||:||:||||....|.:|||.
Mouse    66 VYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQDL 130

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            |||:.||||||:||||||:|.:||||||.|:|||:||||||..|:.|:.|.:..|||||.|::|.
Mouse   131 FCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEI 195

  Fly   196 KVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHK-IEDR 259
            |.:|:||:.|.:.||::|||:|.||||:.|:|:.|.|::|:.::|: .|..|...|.|.| ::|:
Mouse   196 KTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLR-AEDTKERSAGELKEMQDK 259

  Fly   260 IANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTI 324
            |.|.:...::|..:::::...::|::::.|.|.||.:|:||...:..:.:...:..:....:..:
Mouse   260 IVNLQEVLSENEKKIKALNCEIEELERRKDKETGGKLKSLEDACAEAQRVNTKSQSAFDLKKKNL 324

  Fly   325 QQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLST 389
            ..:|.|.:....::.:|.:|||.||.::.|:......|:||..:|::|...||:...|||.|||:
Mouse   325 ASEETKRKELQNSMAEDSKALAAKEKEVKKITDGLHGLQEASNKDAEALAAAQQHFNAVSAGLSS 389

  Fly   390 NENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQL 454
            ||:|..:||..|:|..|...|:|||..|.::::|:|.:..||.::.|.:..|:.|.||:...:.:
Mouse   390 NEDGAEATLAGQMIACKNDISKAQTEAKQAQMKLKHAQQELKSKQAEVKKMDSGYKKDQDAFEAV 454

  Fly   455 VVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQ--YQDPEPNFDR 517
            ....:.||.:::.|:||....|||.::...|.....:||.:.:...|...:||  |:|||.|::|
Mouse   455 KKAKEKLETEMKKLNYEENKEEKLLEKHRQLSRDINNLKGKHEALLAKFPNLQFAYKDPEKNWNR 519

  Fly   518 RKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRVTLIPINKIQSG 582
            ..|:|||..|..|||...:.||...||..||:.|.|.:||:||:|::|.|:||.|:||:|||.:.
Mouse   520 NSVKGLVASLINVKDNSTATALEVVAGERLYNVVVDTEVTAKKLLEKGELKRRYTIIPLNKISAR 584

  Fly   583 SLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRS 647
            .:....:..|||.||.:||..|:||:||....:..|:|.||.|.:|.::..||::::|.||..|:
Mouse   585 CIAPETLRVAQNLVGPDNVHVALSLVDYKPELQKGMEFVFGTTFVCNNMDNAKKVAFDKRIMTRT 649

  Fly   648 VTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNK 712
            |||.|||.|||||:||||..:.|::|.:...:|.::.|.|..::|:..:|:::|.::|.|..:.:
Mouse   650 VTLGGDVFDPHGTLSGGARSQAASILTKFQEVKDVQDELRTKENELRALEEELAGLKNVAEKYRQ 714

  Fly   713 MKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAK 777
            :|:..:::..|..:.:.:|.|:::.:.|.|::.:::.::..|:.:..::|.||.::.|...:|.|
Mouse   715 LKQQWEMKTEEGDLLQTKLQQSSYHKQQEELDALKKTIEESEETLKSTKEIQKKAEEKYEALENK 779

  Fly   778 LADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQ--- 839
            :.:|:..||:||..|..::...|.:|:.|....|:::||.|.:.||:.||::  |.|..:.|
Mouse   780 MKNAEAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKR--EHASNEQQLDA 842

  Fly   840 --EMI----DNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKML 898
              |.|    ..:||..||:...|.:.:.|..|:.:.:|.|..|.:.::|:..|     |.|..:
Mouse   843 VNEAIKAYEGQIEKMAAEVAKNKESVNKAQDELMKQKQIITAQDNIIKDKCAE-----VAKHNL- 901

  Fly   899 KENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEA 963
             :|.|.:|::|:.::...|...:|.:|..::..:.:.|.||..||:.||..|:.||:...:|.||
Mouse   902 -QNNESQLKIKELDHSISKHKREADDAAAKVSKMLSDYDWINAEKHLFGQPNSAYDFKTNNPKEA 965

  Fly   964 GNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQL 1028
            |.:|.|:||.|:|:.|.:|:.|:.||...||.:.:..:::.||..||.||...|..:|:::...|
Mouse   966 GQRLQKLQEVKEKLGRNVNLRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQKKNQAL 1030

  Fly  1029 NKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGELSGGQKSLVAL 1093
            |.|..:||.:|..|||:|||||.|.|.|......|.|||.||.....|||:|.||||||:|||||
Mouse  1031 NIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGGQRSLVAL 1095

  Fly  1094 SLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTL 1158
            ||:|:||.|.|||:|||||||||||:|||||||.||:.|||:|||::||||:|:||:|||||:|.
Mouse  1096 SLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVLFKTK 1160

  Fly  1159 FEEGVSTITRQVSRQA 1174
            |.:||||:.|....||
Mouse  1161 FVDGVSTVARFTQSQA 1176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	493/1171 (42%)
Smc2	NP_032043.3	SMC_N	2..1167	CDD:426784	495/1174 (42%)