Protein Alignment SMC2 and Smc1b

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_536718.1
• Gene: Smc1b / 140557
• MGIID: 2154049
• Length: 1248
• Species: Mus musculus
• Alignment Length: 1306
• Identity: 278/1306 - (21%)
• Similarity: 555/1306 - (42%)
• Gaps: 266/1306 - (20%)

  Fly     2 YVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLV 66
            :::.|:::.|||:..|..|..| ..||.|.|.|||||||::|::.||:| ....|:|...:|:|:
Mouse     3 HLELLLVENFKSWRGRQVIGPF-KRFTCIIGPNGSGKSNVMDALSFVMG-EKTTNLRVKNIQELI 65

  Fly    67 Y--KNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQD 129
            :  ..|:...:.|:|||::...:      |.||    :.|| ::.||.:::....|.|.......
Mouse    66 HGAHTGKPVSSSASVTIIYIEDS------GEEK----TFTR-IIRGGCSEYHFGDKPVSRSVYVA 119

  Fly   130 FFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVR- 193
            ...:|.:.|...|.|:.||.::.:...||||.....||.:.:.::..:.:|.|..::|.|...:
Mouse   120 QLENIGIIVKAQNCLVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEEDAQF 184

  Fly   194 ETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDID------FLIRIHISAKYLKQCET-LKTVEA 251
            ...|..:.....|..|:.:|.:  :.||.:..::.      .|.:::.:.:.:....| |:.::.
Mouse   185 HFNVKKNVAAERKHAKIEKEEA--EHYQNLLEELKINKIQLMLFQLYYNEEKINVLNTELEQMDG 247

  Fly   252 NEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGS 316
            |...::|.:     :|.:|:.:.:..:..:...|.|..|:   .:|::|..|:.||      ...
Mouse   248 NLSVVKDTL-----SHHENIFKAKKKDYGMLTRQLQQTAK---ELKSVEAILNQKR------PQY 298

  Fly   317 LKAAQGTIQQDEKKIRMASKNIEDDERALAKKE----------ADMAKVQGEFESLKE----ADA 367
            :||.:.| ....||:.::.|.|.|:|:..:|:|          ||:.:....||...|    ...
Mouse   299 IKAKENT-SHHLKKLDLSKKLITDNEKQCSKQEDGIRALVAELADLDRAWKSFEKQMEEKILQKG 362

  Fly   368 RDSK-----------AYEDAQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEI 421
            ||.:           ..|..::|:..::|.|...: .|....:|:|...|.:..:.|..:|..:.
Mouse   363 RDIELENSQLDRYKLLKEQVRRKVGIMTQQLEKLQ-WEQKAEKERLAFEKRRHGDTQGNLKQIKE 426

  Fly   422 ELRHTRGVLKQREGETQT-NDAAYVKDKKLHDQ-LVVEIKNLERQLQSLDYEGGHFEKLKQRRND 484
            ::...:..:::.|..|:| .|.  ::|||..:: |..||:|.:.::..::      |:|...||:
Mouse   427 QIEEHKKRIEKLEEYTKTCMDC--LEDKKQQEEALKKEIENTKSRMSEVN------EELSLIRNE 483

  Fly   485 L-------HMRKRDLKRE--LDRCNASRYDLQYQDPEPNFDR---------RKVRGLVGKLFQVK 531
            |       |..||..||.  |:.       |:...|:..|.|         :|.:..|.|||
Mouse   484 LQNAGIDNHEGKRQQKRAEVLEH-------LKRLYPDSVFGRLLDLCHPIHKKYQLAVTKLF--- 538

  Fly   532 DMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRR--VTLIPINKIQSGSLNRNVVEYAQN 594
                        |..:.:.|...:..:|..::....:|.  .|.:.::.:....:|..:.|
Mouse   539 ------------GRYMVAIVVASEKIAKDCIRFLKAERAEPETFLALDYLDIKPINERLRE---- 587

  Fly   595 KVGAENVQWAMSLIDYDRYYEP----VMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVV 655
                  ::....:||..:...|    |::|..|..|:|:.:..|:.|::......::|.|:|.:.
Mouse   588 ------IKGCKMMIDVIKTQFPQLKKVIQFVCGNGLVCETVEEARHIAFGGPERRKAVALDGTLF 646

  Fly   656 DPHGTVSGGAAPKGANVL----EELHAIK----QIEKEYREI------DSEIAQVEKQIASIENQ 706
            ...|.:|||::......|    :|||.::    |:.:|.:|:      ::::.|::..:.....:
Mouse   647 LKSGVISGGSSDLKHKALCWDEKELHNLRDKRSQLVQELKELMKTLRKETDLKQIQTLVQGTNTR 711

  Fly   707 ALAFNKMKENLDLRQHELTMCENRLAQTTFQ---QNQAEIEEMRERVKTLEQQIIDSREKQKTSQ 768
                      |...|:||.|.:.:...|.::   |.|:|:..:..:...|.:.|...::|.:..|
Mouse   712 ----------LKYSQNELEMIKKKHLATFYREQSQLQSELLNIDSQCTMLSEGINKQQQKIEEFQ 766

  Fly   769 AKIVDIEAKL---------------ADAKGYRERELNAATNEIKVTKQRA------EKSRANWKK 812
            .||.::|..:               .:.|..::::.| ....::..||:.      |.||...||
Mouse   767 DKIDEVEDDIFQDFCEEIGVENIREFENKHVKQQQEN-DQKRLEFEKQKTRLNIQLEYSRNQLKK 830

  Fly   813 REQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQK 877
            :....:||:..|.:.::.|:..||..:|.:..:|:...:.:.:|...::.:|.:.::...|:|::
Mouse   831 KLNNIDTLKTTIQKGKEDIDNLKKTEEECLKIVEELMVKQEQIKEVLATQSSNIEKIHIQIEEER 895

  Fly   878 DKLRDQNKE--------------MRNQLVKKEKMLKE---------------NQEIELEVKKKEN 913
            .|:...::|              :..:|::|..:|.:               ...||:|:.:.|:
Mouse   896 KKVLAVDREVGKLQKEVVIIQGSLEQKLLEKHNLLLDCKVQDIDISLVLGSLEDIIEMELTETES 960

  Fly   914 EQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYS--KED------PHEAGNKLAKM 970
            .|.......|||                        :.:.|||  :||      ..|....|..:
Mouse   961 TQATADIYEKEA------------------------SIQIDYSPLREDLKALQSDKEVEAHLTLL 1001

  Fly   971 QEKKDKMERTL------NM----NAIMVLDREEEN---FKETERRRNIVAMDKEKIKKIIVKMDE 1022
            .::....|.||      |:    |...|.|:.:|:   |:.:.:...|...:.|::|:
Mouse  1002 LQQVASQENTLLKTTAPNLRAQENLKTVRDKFQESADVFEASRKEARICRQEFEQVKR------- 1059

  Fly  1023 EEQDQLNKAATEVNTNFSGIFSSLL--PGAEAKLNPVH-TNGCLTGLEIKVGFNGIWKESLGELS 1084
            ...|..::....::.:...|:..|.  ..|:|.|:|.: ....|.|:.......|.....:..||
Mouse  1060 RRYDAFSQCFEHISVSIDQIYKKLCRNNSAQAFLSPENPEEPYLDGISYNCVAPGKRFMPMDNLS 1124

  Fly  1085 GGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNS-QFLIVSLKDGLF 1148
            ||:|.:.||:|:.|:..|.|||.::|||||||||.::...:.|.:|:..... |.:|:|||:..:
Mouse  1125 GGEKCVAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQSQEQFQMIIISLKEEFY 1189

  Fly  1149 NHANVL 1154
            :.|:.|
Mouse  1190 SKADAL 1195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	278/1306 (21%)
Smc1b	NP_536718.1	SMC_N	3..1203	CDD:481474	278/1306 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1219..1248