Protein Alignment SMC2 and SMC5

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_061511472.1
• Gene: SMC5 / 1281007
• VectorBaseID: AGAMI1_009009
• Length: 1052
• Species: Anopheles gambiae
• Alignment Length: 1235
• Identity: 239/1235 - (19%)
• Similarity: 450/1235 - (36%)
• Gaps: 375/1235 - (30%)

  Fly    25 PE--FTAITGLNGSGKSNILDSICFVLG-----ISNLQNVRASALQDLVYKNGQAGITKATVTI- 81
            ||  ...|.|.||:|||.|:..|...:|     :|...|:      |...|||:   ..||:.|
Mosquito    44 PEEYLNIILGPNGTGKSAIVAGIVLGMGGNCKLLSRCDNI------DSYIKNGK---DSATIRIS 99

  Fly    82 VFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDFFCSIQLNVNNPNFLIM 146
            ::.|...|        .|..|  |......|:.|.|:.:.|..:.......:..:.|:|....:.
Mosquito   100 IYRNNERA--------VRWFS--RSFDHSAKSTFEIDNQTVSQQAYLQQIRAFNIQVDNLCQFLP 154

  Fly   147 QGKIQQVLNMKPKEVLSMVEEAAGT-------SQYKTKRDATKTLIEKKET--------KVRETK 196
            |.::|....|.|:|:|...:.:..|       .:.|.||.     :::|.|        :|||.:
Mosquito   155 QDRVQDFTKMNPRELLLNTQSSVCTPEVQQWFEELKEKRS-----LQEKSTNQGAEGTARVRELE 214

  Fly   197 VLLDE-EVLPKLVKLRQE----------RSAYQEYQKICRDIDFLIRIHISA-----KYLKQCET 245
            ..|:. |...:.::.|:|          |.|:.||:::     ||:   .||     |..|:|..
Mosquito   215 ARLEALEAQLQSMRAREEFQQQIHVCMARKAWLEYEEL-----FLL---YSATLKDLKLAKKCTE 271

  Fly   246 LKTVEANEHKIE-----DRIANCKATHAKNLA-------EVESIENSVKEMQQQIDAEMGGSIKN 298
            .|..:.|:.|.|     .|....:.:.||.:|       |:.|:|...:.::..|..:
Mosquito   272 EKEQQYNQFKQEMEAILARKKELETSKAKQVAIGQRSTDEINSLEEKTERLEDTISKQ------- 329

  Fly   299 LETQLSAKRAL-EATATGSLKAAQGTIQQDEKKIRMAS--KNIEDDERALAKKEADMAKVQGEFE 360
                   ||.| :|.|    ||.:...:.||.|:.:|:  ::..|...||..::    :|:.|..
Mosquito   330 -------KRELMDALA----KADERKTELDEAKVMLAAFVQDCADSATALGSED----QVRQEIS 379

  Fly   361 SLKEADARDSKAYED---AQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIE 422
            .|   |.:::|...|   ...:.:.::|.:.|....|..:::..:        |....:.::::.
Mosquito   380 VL---DGKEAKIRADNDLLMGRRQELNQKIDTELKPEMMSIERSI--------ETIENVASNKLR 433

  Fly   423 LRHTR------GVLKQREGETQTNDAAYVKDKKLHDQLVVE--------IKNLERQLQSLDYEGG 473
            :..||      .||..||.:       ::...|:::.:::|        ::.||..:...|....
Mosquito   434 ILQTRFEGTYKAVLWLREHK-------HLFQGKIYEPMILELNVPALENVQFLENTIGVRDLIAF 491

  Fly   474 HFEKLKQRRNDLHMRKRDLKRELDRCNASRYD----LQYQDPEPNFDRRKVRGLVGKLFQVKDMQ 534
            ..|..:..  :|.:||...:..:|..||.:.|    |.|....|          :|.|.:.
Mosquito   492 TCESTQDM--NLFLRKTREELRIDGVNAIQSDPADKLHYTARHP----------IGSLKRF---- 540

  Fly   535 NSMALVQTAGGSLYSYVTDDDVTSKKILQRGN---LQRRVTLIPINKIQSGSLNRNVVEYAQNKV 596
                       ..::|:.|        :.:|.   |.....|..::.|..|
Mosquito   541 -----------GFHTYLID--------MVQGPYPVLNGLCKLYGLHNIPVG-------------- 572

  Fly   597 GAENVQWAMSLID-YDRYYEPVMKFCFGGTLICKDLIVAKQIS---YDPRINCRSVTLEGDVVDP 657
            ||::.::..:|.| ...::.|..:|               |:|   |....:.||..|
Mosquito   573 GADSAKYVSALPDEIGLFFTPSHRF---------------QVSKSRYTGEKSTRSDAL------- 615

  Fly   658 HGTVSGGAAPKGANVLEEL--HA-IKQIEKEYREIDSEIAQVEKQIASIENQALAFNKMKEN-LD 718
                      :..|:|...  || :.|..:|::.:..|..::..|...|||   :..:::|. .:
Mosquito   616 ----------RTLNLLNRSTDHALLAQKRQEHQRLVRECDKIRNQRGQIEN---SIKELQERCAE 667

  Fly   719 LRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKG 783
            ||:.:..:.|.   .:.:||.:.:::...::.|.|..::::..|::...:.....|..:|.|.:.
Mosquito   668 LREQKRDLQEQ---LSKYQQTKMKVKRQEQKCKELTARLVNVDEEKVKFERSCRTIIEQLLDQQR 729

  Fly   784 YRERELN---AATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNL 845
            .:...|.   ||:.|..:.:||..........||..|..       |:.:.::|||    .:.|:
Mosquito   730 RKVAALERYAAASREHDLLEQRIRLFEERNNDREANFRL-------LEDAYQSAKK----TLANV 783

  Fly   846 EKFKAELDALKVNSSSAA-----------------SEVTELEQAIKEQKDKLRDQN-KEMRNQLV 892
            ||..||:.|...:.:|.|                 .|.|||...|     :|.|.: :|:|   |
Mosquito   784 EKKLAEVKAKSSDKNSTARALCANKTPDKPDFPYRKEFTELPDTI-----ELVDAHLEELR---V 840

  Fly   893 KKEKMLKENQEI--ELEVKKKENEQKKIS---SDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTR 952
            :.|.:.:.|:.:  |...||::.||.:..   |:...|....:..|....|.||.::.....|.:
Mosquito   841 RFECLPQANESVADEYAQKKRQLEQLRAGVACSEQTVATLEQQMAELHDRWYPEIQSVVQCINGK 905

  Fly   953 YDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKII 1017
            :.:.......||                           |.|..::.||     ..|:..| :|.
Mosquito   906 FSHFMSSMGFAG---------------------------EVELIRQGER-----DYDEYGI-RIY 937

  Fly  1018 VKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGE 1082
            ||...||:                                     |:.|:.|:
Mosquito   938 VKYRNEEK-------------------------------------LSALDRKL------------ 953

  Fly  1083 LSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFT---NSQFLIVSLK 1144
            .|||::::......|::...:..|...:||::..:|.::.:.:.:||.:...   .||:..|:.|
Mosquito   954 QSGGERAVAIAIYTLSLQHMTQVPFRCVDEINQGMDPTNERKVFNMLVEETCRTGQSQYFFVTPK 1018

  Fly  1145  1144
            Mosquito  1019  1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	239/1235 (19%)
SMC5	XP_061511472.1	None