Protein Alignment SMC2 and SMC2

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_006435.2
• Gene: SMC2 / 10592
• HGNCID: 14011
• Length: 1197
• Species: Homo sapiens
• Alignment Length: 1192
• Identity: 483/1192 - (40%)
• Similarity: 778/1192 - (65%)
• Gaps: 17/1192 - (1%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            |::|.::|:|||||.:|||:.||||.|.|||||||||||||||||||:||||||..||||.||||
Human     1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            ||||||||||||:|:|.|||::..|.|.|:|...||:||||||:||:||:||||....|.:|||.
Human    66 VYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGVNANNTRVQDL 130

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            |||:.||||||:||||||:|.:||||||.|:|||:||||||..|:.|:.|.:..|||||.|::|.
Human   131 FCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEI 195

  Fly   196 KVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHK-IEDR 259
            |.:|:||:.|.:.||::|||:|.||||:.|:|:.|.|::|:.::| ..|..|...|.|.| ::|:
Human   196 KTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL-LAEDTKVRSAEELKEMQDK 259

  Fly   260 IANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTI 324
            :...:...::|..:::::.:.::|::::.|.|.||.:::||..|:..:.:...:..:....:..:
Human   260 VIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL 324

  Fly   325 QQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLST 389
            ..:|.|.:...||:.:|.:.||.||.::.|:.....:|:||..:|::|...||:...|||.|||:
Human   325 ACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS 389

  Fly   390 NENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQL 454
            ||:|..:||..|::..|...|:|||..|.::::|:|.:..||.::.|.:..|:.|.||::..:.:
Human   390 NEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV 454

  Fly   455 VVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNA--SRYD---LQYQDPEPN 514
            ....:.||.:::.|:||....|.|.::|..|   .||:.|..:...|  :|:.   ..|:|||.|
Human   455 KRLKEKLEAEMKKLNYEENKEESLLEKRRQL---SRDIGRLKETYEALLARFPNLRFAYKDPEKN 516

  Fly   515 FDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRVTLIPINKI 579
            ::|..|:|||..|..|||...:.||...||..||:.|.|.:||.||:|:||.|:||.|:||:|||
Human   517 WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKI 581

  Fly   580 QSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRIN 644
            .:..:....:..|||.||.:||..|:||::|....:..|:|.||.|.:|.::..||::::|.||.
Human   582 SARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIM 646

  Fly   645 CRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALA 709
            .|:|||.|||.|||||:||||..:.|::|.:...:|.::.|.|..::|:..:|:::|.::|.|..
Human   647 TRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEK 711

  Fly   710 FNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDI 774
            :.::|:..:::..|..:.:.:|.|:::.:.|.|::.:::.::..|:.:.:::|.|:.::.|...:
Human   712 YRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVL 776

  Fly   775 EAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQ 839
            |.|:.:|:..|||||..|..::...|.:|:.|....|:::||.|.:.||:.||::...:.|:|.:
Human   777 ENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLE 841

  Fly   840 EMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEI 904
            .:.:.::.::::::.:....:.....|.:.::.:.:||:.:..|:..::.:..:..|..::|.:.
Human   842 AVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDS 906

  Fly   905 ELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAK 969
            :|::|:.::...|...:|::...::..:...|.||..|::.||..|:.||:...:|.|||.:|.|
Human   907 QLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQK 971

  Fly   970 MQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATE 1034
            :||.|:|:.|.:||.|:.||...||.:.:..:::.||..||.||...|..:|:::...||.|..:
Human   972 LQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQK 1036

  Fly  1035 VNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGELSGGQKSLVALSLVLAM 1099
            ||.:|..|||:|||||.|.|.|......|.|||.||.....|||:|.||||||:|||||||:|:|
Human  1037 VNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSM 1101

  Fly  1100 LKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVS 1164
            |.|.|||:|||||||||||:|||||||.||:.|||:|||::||||:|:||:|||||:|.|.:|||
Human  1102 LLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVLFKTKFVDGVS 1166

  Fly  1165 TITR-------QVSRQATTNKR 1179
            |:.|       ::|::|.:..:
Human  1167 TVARFTQCQNGKISKEAKSKAK 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	475/1165 (41%)
SMC2	NP_006435.2	SMC_N	2..1167	CDD:426784	479/1170 (41%)