DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-T and slc17a5

DIOPT Version :9

Sequence 1:	NP_001260981.1	Gene:	NaPi-T / 36651	FlyBaseID:	FBgn0016684	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001070195.1	Gene:	slc17a5 / 767760	ZFINID:	ZDB-GENE-060929-1158	Length:	488	Species:	Danio rerio

Alignment Length:	474	Identity:	157/474 - (33%)
Similarity:	249/474 - (52%)	Gaps:	39/474 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ARTVLWYMTFIGFIVNYMIRINLNITIVDMIAGKGAITSNETHENSTDLAALAEMNERFSLERWF 70
            :|..|.:::..||.|.|.:|:||::.:|||:       .|.:..|::.......
Zfish    35 SRYGLAFLSCYGFFVAYALRVNLSVAMVDML-------KNSSKANTSSSICPPH----------- 81

  Fly    71 LDWANIPYEKNG-----FHWNEKQQGALLGSFFWAHWTLQIPGGILATKYGTKLVFGWSNGIGVF 130
                |||..|:.     :.||.:.||.:|||||:.:...|||||.||.|||.|    |..|:|:.
Zfish    82 ----NIPVPKHNHTAMVYDWNSETQGWILGSFFYGYIITQIPGGYLARKYGAK----WLLGLGIL 138

  Fly   131 C----CFLIPIVSYWSYTGLIILRVFQGWITGLAWPSMHVLTAKWIPPNERSKFVS-AYLGSSVG 190
            |    ..|.|:.:......||.:||.:|...|:.:|:||.:.|.|.||.|||:.:: :|.|:.:|
Zfish   139 CTVIFTLLTPLAADLGAGYLIAVRVLEGIGEGVTYPAMHAMWASWAPPLERSRLLTISYTGAQLG 203

  Fly   191 VALFYPIFGYIIDWTRWEWVYYICGIVGTLWFIAWQFLVFDSPAEHPRIADSERKFIEKSLGASI 255
            ..:..|:.|.|..:..|.:|:||.|.||.|||..|...|.:||:.|.||.::|:.:|..||...:
Zfish   204 TVVALPLSGQICFYLDWTYVFYIFGAVGLLWFFLWICFVSNSPSSHKRITEAEKTYIMSSLKNEL 268

  Fly   256 QGSKGPTPWKAIATSRPVWLNVVAQWGGIWGLFTLMTHAPTYFRLIHHWNIRATGFLSGLPHLMR 320
            ..::...||.:|..|.|:|..|||.:...|..:||:|..|||...:..::|:..|.||.||:|..
Zfish   269 SPTQDYIPWTSIFKSMPLWAIVVAHFSYNWTFYTLLTLLPTYMNDVLGFSIQQNGMLSALPYLGC 333

  Fly   321 MLFAYVFSIFADYLLRTDKMSRT-NVRKLATFICCGTKGLIVLALAYFGYNATAAIVLVTVATML 384
            .|.|.:....|| |||...:.|| .|||..|.:......:.::|..|.|.|...|:..:|:::.|
Zfish   334 WLLALLGGQLAD-LLRERFLFRTVIVRKAFTVVGMAGPAVFLVAAGYTGCNYILAVAFLTISSSL 397

  Fly   385 HGAVSSGPLASMVDLSPNYAGIVLGVSGMIGGMPGFISPFIVGQLTHNNQTIDAWKNVFLLTSLM 449
            .|..:||...:.:|::|:||||:||::.....:||.:.|.|...||.:| ||..|:.||.:::.:
Zfish   398 GGISASGFNINHLDIAPSYAGILLGITNSFATIPGMVGPVIARSLTKSN-TIPEWQIVFYISAAI 461

  Fly   450 LTGSGILYVLFSESKLQPW 468
            .....:.:.:|.:..:|||
Zfish   462 NIFGAVFFTIFGKGTVQPW 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-T	NP_001260981.1	2A0114euk	1..474	CDD:129972	157/474 (33%)
NaPi-T	NP_001260981.1	MFS	76..460	CDD:119392	138/394 (35%)
slc17a5	NP_001070195.1	2A0114euk	27..488	CDD:129972	157/474 (33%)
slc17a5	NP_001070195.1	MFS	92..472	CDD:119392	135/385 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910