DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn6 and AgaP_AGAP001440

DIOPT Version :9

Sequence 1:	NP_725412.2	Gene:	Rpn6 / 36638	FlyBaseID:	FBgn0028689	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	XP_003435832.1	Gene:	AgaP_AGAP001440 / 1281739	VectorBaseID:	AGAP001440	Length:	416	Species:	Anopheles gambiae

Alignment Length:	422	Identity:	352/422 - (83%)
Similarity:	382/422 - (90%)	Gaps:	6/422 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MAGATLFERAQALSSVNREEQDSSLLNKLVRDQEGAENDEERIRIKEQGILQQGELYKQEGKAKE 82
            ||||.:.:|||: .|:||::     :....||.|..|||||:||.|||.||:.||.||:||||||
Mosquito     1 MAGAMMIDRAQS-HSLNRQD-----MTNFARDLEVDENDEEQIRQKEQKILELGETYKKEGKAKE 59

  Fly    83 LADLIKVTRPFLSSISKAKAAKLVRSLVDMFLDMDAGTGIEVQLCKDCIEWAKQEKRTFLRQSLE 147
            |||||||||||||.:||||||||||||||:|||::|.|||||||||:||||||||||||||||||
Mosquito    60 LADLIKVTRPFLSFLSKAKAAKLVRSLVDLFLDLEAETGIEVQLCKECIEWAKQEKRTFLRQSLE 124

  Fly   148 ARLIALYFDTALYTEALALGAQLLRELKKLDDKNLLVEVQLLESKTYHALSNLPKARAALTSART 212
            ||||||||||.:|||||.||:|||:||||||||||||||||||||||||||||||||||||||||
Mosquito   125 ARLIALYFDTGMYTEALNLGSQLLKELKKLDDKNLLVEVQLLESKTYHALSNLPKARAALTSART 189

  Fly   213 TANAIYCPPKVQGALDLQSGILHAADERDFKTAFSYFYEAFEGFDSVDSVKALTSLKYMLLCKIM 277
            |||||||.||||..|||||||||||||||||||||||||||||||||.|.||||:||||||||||
Mosquito   190 TANAIYCAPKVQATLDLQSGILHAADERDFKTAFSYFYEAFEGFDSVQSSKALTALKYMLLCKIM 254

  Fly   278 LGQSDDVNQLVSGKLAITYSGRDIDAMKSVAEASHKRSLADFQAALKEYKKELAEDVIVQAHLGT 342
            |||||||||:||||||||||||||||||:||||||||||||||.|||:|||||.:||||:|||||
Mosquito   255 LGQSDDVNQIVSGKLAITYSGRDIDAMKAVAEASHKRSLADFQDALKQYKKELEDDVIVKAHLGT 319

  Fly   343 LYDTMLEQNLCRIIEPYSRVQVAHVAESIQLPMPQVEKKLSQMILDKKFSGILDQGEGVLIVFEE 407
            ||||||||||||||||||:.:|:.:||.|.||:.||||||||||||||||||||||.||||||||
Mosquito   320 LYDTMLEQNLCRIIEPYSQCEVSFIAEQIALPIAQVEKKLSQMILDKKFSGILDQGIGVLIVFEE 384

  Fly   408 TPVDKTYERVLETIQSMGKVVDTLYQKAKKLS 439
            ||||||||..|||||.|||||||||||||||:
Mosquito   385 TPVDKTYETALETIQHMGKVVDTLYQKAKKLT 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn6	NP_725412.2	RPN6	18..438	CDD:227488	350/419 (84%)
Rpn6	NP_725412.2	PCI	302..406	CDD:279707	86/103 (83%)
AgaP_AGAP001440	XP_003435832.1	RPN6	33..415	CDD:227488	335/381 (88%)
AgaP_AGAP001440	XP_003435832.1	PCI	279..383	CDD:279707	86/103 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	283	1.000	Domainoid score	I4076
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2108
Inparanoid	1	1.050	673	1.000	Inparanoid score	I1996
OMA	1	1.010	-	-		QHG53498
OrthoDB	1	1.010	-	-		D1052430at2759
OrthoFinder	1	1.000	-	-		FOG0003528
OrthoInspector	1	1.000	-	-		oto107578
Panther	1	1.100	-	-	LDO	PTHR10678
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2408
TreeFam	0	0.000	Not matched by this tool.
	11	11.080