DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12863 and zcchc4

DIOPT Version :9

Sequence 1:	NP_610973.3	Gene:	CG12863 / 36623	FlyBaseID:	FBgn0033948	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_001107071.1	Gene:	zcchc4 / 564410	ZFINID:	ZDB-GENE-080204-65	Length:	484	Species:	Danio rerio

Alignment Length:	486	Identity:	149/486 - (30%)
Similarity:	234/486 - (48%)	Gaps:	88/486 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KLLLEMEEDDAAPEDQHPRCEHGPTVLFNRQSQLPDQ---GYYACSAHRDSKLCNYHLPADQWKG 69
            :::::.|.|..|     |||.|||.:||.:.....::   .:|||||.||.|.||:...||:...
Zfish    15 EVIVQNESDKTA-----PRCPHGPALLFEKTGHGEEEKGRRFYACSACRDRKDCNFFQWADEKIS 74

  Fly    70 QTTRTA----------------------------LTKRDYPLPCRKPANPA-------------- 92
            :....|                            |.:|.:.:.|:....|.
Zfish    75 EARMLAREEQNCSKKPLFTHQQYYSRFLEFASLPLEQRRFCVDCQLLILPGEWMNHTKHRALSED 139

  Fly    93 -----ICDPTLSLTALSQDKVNAQYFFDEAALNFLANQCEHIGASKVICMGAPRLHFHLRHK--- 149
                 :..|:|.|..|...|.||||.|.|.:.:||.:....:|..|::|:|.||||..::.:
Zfish   140 VTVQRLKKPSLLLRPLDNKKSNAQYLFAERSCHFLLDTLSTLGFRKLLCVGTPRLHEMIKIRNLE 204

  Fly   150 -----LQSFLLDLDERFAEYLGPEEFCLYNMCNNHFFYDRTP---FEQFLAGTSSDRLVIVTDPP 206
                 ::|.|||:|.|:.::.|.:|||.|||.|:|||.|...   |:.||.....::||::||||
Zfish   205 DKSPVIRSLLLDIDYRYCQFYGQDEFCRYNMFNHHFFDDEEAVKFFQGFLQEEGGEKLVMITDPP 269

  Fly   207 FGCRTELISHTLRSLRKLHNQINRL--PSTPLSIFWIYPYYSANHIRQEMPELEMCEYRINYTNH 269
            ||...:.::::...:......:|::  .|..:.:.||:||:..:.|.:..|...|.:|:::|.||
Zfish   270 FGGLVKPLANSFSQISMTWKNLNKVSDASAEMPMIWIFPYFFESRILECFPSFSMLDYQVDYDNH 334

  Fly   270 LRYTNVGKQSRFCGSPVRLFTNVPLRLLQLPPEEGYKYCQKCDCYTAKENLHCNRCGKCPSVNGQ 334
            ..|.: ||..| ..||||||||:..:.:.||..|||::|..|:.|.:..|.||.:|..|||.:|:
Zfish   335 PLYKH-GKTGR-KQSPVRLFTNLSPKDIILPEAEGYRFCSVCERYVSAGNKHCPKCDMCPSKDGR 397

  Fly   335 TYKHCESCDACVKPNYVHCSDCRRCTQKEGHNCSFYQTKQHCWMCGQKGHIETKCPNFRKRKTNY 399
            .::||:.|..||||::.|||.|.||...: |.|...||  .|:.||.:.|....||.
Zfish   398 EWRHCDECGRCVKPSWRHCSSCGRCALPD-HPCGQRQT--GCFNCGSQKHKLRACPK-------- 451

  Fly   400 TKGCLLCGKR------NHREKRCSYRSKYFR 424
             |..|:.|.|      .|:..:...::|..|
Zfish   452 -KRMLVSGDRGAPGLSKHKAGKSRAKNKQKR 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12863	NP_610973.3	N6-adenineMlase	111..>224	CDD:287239	43/123 (35%)
CG12863	NP_610973.3	PTZ00368	299..416	CDD:173561	44/122 (36%)
zcchc4	NP_001107071.1	zf-GRF	27..72	CDD:284302	20/44 (45%)
		N6-adenineMlase	163..>270	CDD:287239	40/106 (38%)
		DZR	371..420	CDD:289539	21/48 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592490
Domainoid	1	1.000	109	1.000	Domainoid score	I6337
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14632
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3280
OMA	1	1.010	-	-		QHG46102
OrthoDB	1	1.010	-	-		D312577at33208
OrthoFinder	1	1.000	-	-		FOG0005131
OrthoInspector	1	1.000	-	-		oto40831
orthoMCL	1	0.900	-	-		OOG6_107511
Panther	1	1.100	-	-	LDO	PTHR13493
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910