Protein Alignment Su(var)2-HP2 and RP1

DIOPT Version :9

• Sequence 1: NP_610972.2
• Gene: Su(var)2-HP2 / 36621
• FlyBaseID: FBgn0026427
• Length: 3257
• Species: Drosophila melanogaster
• Sequence 2: XP_016869210.1
• Gene: RP1 / 6101
• HGNCID: 10263
• Length: 2163
• Species: Homo sapiens
• Alignment Length: 2275
• Identity: 422/2275 - (18%)
• Similarity: 796/2275 - (34%)
• Gaps: 672/2275 - (29%)

  Fly    63 ELLKEGS------GSKSQ----DRRRRPPSPSSSDESNDA--------------------LEALF 97
            |.|::|.      |.|.|    |:.||.|.|..|..:..|                    |....
Human   103 EELEDGESYLCSHGRKVQPVDLDKARRRPRPWLSSRAISAHSPPHPVAVAAPGMPRPPRSLVVFR 167

  Fly    98 CG--KSSQSKLSKRR--ERYESFDSVDDLGEALMRPSHRL------TVPK--------------- 137
            .|  |:.::.|..||  :.:|:|  :..|.|.:.||..:|      .||.
Human   168 NGDPKTRRAVLLSRRVTQSFEAF--LQHLTEVMQRPVVKLYATDGRRVPSLQAVILSSGAVVAAG 230

  Fly   138 --------------------PSTSQ----AGSKKSQDAAPHRSISNSSSSNI-AMSSGQTY---- 173
                                |..||    .|:.||:.......:|:||.|.| ::||.:|:
Human   231 REPFKPGNYDIQKYLLPARLPGISQRVYPKGNAKSESRKISTHMSSSSRSQIYSVSSEKTHNNDC 295

  Fly   174 ------------ACPKNKKTN--------SVANKTAVSANGD-----------------KWASGK 201
                        |..||...|        .:......:.:|.                 ||.:..
Human   296 YLDYSFVPEKYLALEKNDSQNLPIYPSEDDIEKSIIFNQDGTMTVEMKVRFRIKEEETIKWTTTV 360

  Fly   202 NKTVTIVKPQKTDLR-PSRLEPKTDPLNLGDLYGDSDSDSSYEYESDFYGDQDSDEEDEPVIDIS 265
            :||......:|:::. |.|.|.::..|.|......:|. |..|..|    :|:....:|..|.::
Human   361 SKTGPSNNDEKSEMSFPGRTESRSSGLKLAACSFSADV-SPMERSS----NQEGSLAEEINIQMT 420

  Fly   266 TDTSRTTSVADTVTPVVSDDEGQEPQSELNQRHANDQESFLSSTYERLQSYLSNLSSAEPPPIYK 330
            ...:.|.|.|......|..|..|..|.:...|........|....:: :|.:.:::......:.:
Human   421 DQVAETCSSASWENATVDTDIIQGTQDQAKHRFYRPPTPGLRRVRQK-KSVIGSVTLVSETEVQE 484

  Fly   331 K---QNSARKSRSNEKKPSSSQQVKHA-NEQSAASDKEA--------NKKERDLEPPEASSSAKS 383
            |   |.|..:.|.:.:..|......|: ::.|:.|:|..        ..:|..||..:.:|..||
Human   485 KMIGQFSYSEERESGENKSEYHMFTHSCSKMSSVSNKPVLVQINNNDQMEESSLERKKENSLLKS 549

  Fly   384 SASKAS----GSRKLYD----------VANNATLE--AVERMSLD-------------LAEQIME 419
            ||..|.    .|:|:.:          ::||:.:|  .|:.:.||             ..::...
Human   550 SAISAGVIEITSQKMLEMSHNNGLPSTISNNSIVEEDVVDCVVLDNKTGIKNFKTYGNTNDRFSP 614

  Fly   420 IDVERSYEFEKRSASKSRSLSRSKIPADSSTSQLGHVRKLTYSSERLDQPEPLGTQLRRSKSESL 484
            |..:.:: |...::...:::|.:  ||..::|.:         :.|:|:   |..:..:.....|
Human   615 ISADATH-FSSNNSGTDKNISEA--PASEASSTV---------TARIDR---LINEFAQCGLTKL 664

  Fly   485 PKRGRP-----RGQKQRKNRGATMEEKSANCRDGEGEPVKRKRGRPRKIIPKEEAKTAETENTIE 544
            ||..:.     ..:|::|:|     :::.|.|..:|:..                       |..
Human   665 PKNEKKILSSVASKKKKKSR-----QQAINSRYQDGQLA-----------------------TKG 701

  Fly   545 SLNTNVPLSIDTSKENPETETVNLEVPIKQDELVSDLDNAKELTGSTNLPQDDIEMASNHQETDL 609
            .||.|              |.:|.:..|.::.:|.|.|:  .|.|.. |.::|::.:....|::.
Human   702 ILNKN--------------ERINTKGRITKEMIVQDSDS--PLKGGI-LCEEDLQKSDTVIESNT 749

  Fly   610 KCAPDRV--ALDKSESTPKVEEEQLCKVD--TPSDTALDESKVSESAKNHIELEDKDKDKEETQK 670
            .|:...:  .:.|:....|:...|..||.  .....:...:|:|..|....|:..:|       |
Human   750 FCSKSNLNSTISKNFHRNKLNTTQNSKVQGLLTKRKSRSLNKISLGAPKKREIGQRD-------K 807

  Fly   671 ESPNGNS---KETNENSVI--VTNEVELPAK-----KAEAKAEAGNIVEESDSQLAEDFKLAEEI 725
            ..|:..|   |.|.||..:  |.|.:|...|     :::|:..:|.:...:...|..  |:.:..
Human   808 VFPHNESKYCKSTFENKSLFHVFNILEQKPKDFYAPQSQAEVASGYLRGMAKKSLVS--KVTDSH 870

  Fly   726 LAAEVGKGVEANEVSVTSVQGEQNPVIEI--VKELEQETISEVVPAQNDQSSVEDQTLADKENPV 788
            :..:..|..:.::|..:::..:|:.....  :..|::....|.:...:.|:.:  |:.....||.
Human   871 ITLKSQKKRKGDKVKASAILSKQHATTRANSLASLKKPDFPEAIAHHSIQNYI--QSWLQNINPY 933

  Fly   789 EKPSPVKAPSSSKDEPPAEENLPAPDQDPIEQQKTPVAKNQQHDKEHNEAPKAESLSVSDIPSSS 853
            ....|:|:                          .||.:|:                     :|.
Human   934 PTLKPIKS--------------------------APVCRNE---------------------TSV 951

  Fly   854 VTPSKKRNHSSPANTPKKSKEIEALQSSVPRRALRSDK-------ATPQNLRESRSKRTL----- 906
            |..|   |:|...|.|..:      ...:....:.|:|       .|..||.:...|..:
Human   952 VNCS---NNSFSGNDPHTN------SGKISNFVMESNKHITKIAGLTGDNLCKEGDKSFIANDTG 1007

  Fly   907 -----KTELTLLMDD---------TMRRSSPRLGRSPAESHSSHERSPMEKKVTVSK--LAKDLI 955
                 :|::..|.|.         |:.:|:  :.....:||.:.|:|..|||:...:  ||:...
Human  1008 EEDLHETQVGSLNDAYLVPLHEHCTLSQSA--INDHNTKSHIAAEKSGPEKKLVYQEINLARKRQ 1070

  Fly   956 TIDKEKEIELKSLPDASET-KD---VKITKTTTASDTSILTDEN-----PSSSKTEMKKLKGKPL 1011
            :::...:::    |...|| ||   |.:.....||...|...:|     |.|       |.|.|.
Human  1071 SVEAAIQVD----PIEEETPKDLLPVLMLHQLQASVPGIHKTQNGVVQMPGS-------LAGVPF 1124

  Fly  1012 KAKKMSRTSETEVKKAIADSNEDI-----------PSIFSIKCVEEHLTSSESEQKDEKEELLCP 1065
            .:             ||.:|:.::           .|:.|...|:.|..:::|.:.....|:|
Human  1125 HS-------------AICNSSTNLLLAWLLVLNLKGSMNSFCQVDAHKATNKSSETLALLEIL-- 1174

  Fly  1066 KPQIDCTNTDLEQSTAIETDTEQVEEKRSNRRKSRRIRNEKFKTETDTLSDHLDAKKAENASLEI 1130
                        :..||..:.:.::...:|.              .::.:.|....:.|...:.|
Human  1175 ------------KHIAITEEADDLKAAVANL--------------VESTTSHFGLSEKEQDMVPI 1213

  Fly  1131 SMRPKCTLETQQSDPVTAKNKRNSG-----------------------RLSRKEKSVINAAKSEK 1172
            .:...|:....||.|..::|:|..|                       ..|..|...:|.|.|.|
Human  1214 DLSANCSTVNIQSVPKCSENERTQGISSLDGGCSASEACAPEVCVLEVTCSPCEMCTVNKAYSPK 1278

  Fly  1173 DKSPSAISQSTERKQLLNENPS-----KKDKKTEQSGNKKEAVVGPL-DKTETSSSTNIIDKKSN 1231
            :..                |||     ......:|:...|...:|.: ..|:|..|.....:|.|
Human  1279 ETC----------------NPSDTFFPSDGYGVDQTSMNKACFLGEVCSLTDTVFSDKACAQKEN 1327

  Fly  1232 ESFDSAMQPSDR-------------LNQKESAFTKLSSISSPKKIMKDQD--KDLDALS----KG 1277
            .:::.|. |.|.             ||.||:.:|  .::.|.:::.:..|  |||:.|:    |.
Human  1328 HTYEGAC-PIDETYVPVNVCNTIDFLNSKENTYT--DNLDSTEELERGDDIQKDLNILTDPEYKN 1389

  Fly  1278 G----DSNPTIRD-------TGEDSRQTDKKHQEND------TKHEEEDSSKLKANIDETKSSSE 1325
            |    .|:..:.:       ..|...:.||||...|      .:..:::::....:::|.::|.
Human  1390 GFNTLVSHQNVSNLSSCGLCLSEKEAELDKKHSSLDDFENCSLRKFQDENAYTSFDMEEPRTSE- 1453

  Fly  1326 KDAEPISKDSSQDSAKPRLSKPKSRNKRKKNEKKPNDSIAESDIEGGFQVNTETVQATCSTPSES 1390
               ||.|..:|..|::..:|:.:|..:.:.::    ..|..:.:.||.|...|.:|
Human  1454 ---EPGSITNSMTSSERNISELESFEELENHD----TDIFNTVVNGGEQATEELIQ--------- 1502

  Fly  1391 NKKDMVKSDETNEEPNLSETEI-GRIRKRGQAFHIENPKDDLHITPQNENQSIAGVNFEKQVPLP 1454
               :.|::.:|.|..::|...| ...|..|..:.|.:.:  |...|..:....:..|.||
Human  1503 ---EEVEASKTLELIDISSKNIMEEKRMNGIIYEIISKR--LATPPSLDFCYDSKQNSEK----- 1557

  Fly  1455 ESVESDTPIMKIPTKTYLMCTKNKTSLLSASEDPDIVLEPQKLITTSKGDSNPDLDNANNLETSS 1519
            |:.|.:|.::|:..||.      :|...|.| .||:....:..:|:...|..||.|:....:|||
Human  1558 ETNEGETKMVKMMVKTM------ETGSYSES-SPDLKKCIKSPVTSDWSDYRPDSDSEQPYKTSS 1615

  Fly  1520 TQDP-------KEHEF-------SDQTFTDNSDII-----PSCTKKSQIVFPTTPTKSSDQTKNS 1565
             .||       :|.|:       :.:.....:|||     |..|:||| |.|....:.....|.|
Human  1616 -DDPNDSGELTQEKEYNIGFVKRAIEKLYGKADIIKPSFFPGSTRKSQ-VCPYNSVEFQCSRKAS 1678

  Fly  1566 -FITPNRSPKSKRNVSKEAKRLDNSFEESQNAASESSA--SKVQKELRTPTASCRKLRVLIKRTP 1627
             :.:..:|..|...||..:..|....||.|:....|:.  :..:.::..|..         |:..
Human  1679 LYDSEGQSFGSSEQVSSSSSMLQEFQEERQDKCDVSAVRDNYCRGDIVEPGT---------KQND 1734

  Fly  1628 TSSLPTNSRKSIFKKTPAKSKRLTK---ILESMEKTPSREPSVSLGEVNPDSDPVAAESVAVLHE 1689
            .|.:.|:..:.:...   |.|.|.|   :|....:.|.         :..::|..:.:::.
Human  1735 DSRILTDIEEGVLID---KGKWLLKENHLLRMSSENPG---------MCGNADTTSVDTLL---- 1783

  Fly  1690 SDRDLESNEIPNEE--------VFEDTEEASAEDTDNKLKKK------------EDDHE--LEV- 1731
               |..|:|:|...        ..::...:..|:....|:.|            |..||  |:|
Human  1784 ---DNNSSEVPYSHFGNLAPGPTMDELSSSELEELTQPLELKCNYFNMPHGSDSEPFHEDLLDVR 1845

  Fly  1732 NDICAASKNPITDDSTKDASSNKSTDSDVLQETKDELSNSLINATQGEDTPIKELTEEEVPNNKT 1796
            |:.||  |..|.:..|::..|::|      :.....:::|.|:|                 .||.
Human  1846 NETCA--KERIANHHTEEKGSHQS------ERVCTSVTHSFISA-----------------GNKV 1885

  Fly  1797 --VEDESKKQEILKDLEPDNAALEEDTASTAKAAEEMDLYIKEKSNVKSVLAEPETDVTDDEELA 1859
              |.|::.|.:.|......:..|:|     |.:.:::.....:...:.:|:.:|..:  :|...|
Human  1886 YPVSDDAIKNQPLPGSNMIHGTLQE-----ADSLDKLYALCGQHCPILTVIIQPMNE--EDRGFA 1943

  Fly  1860 ---QSPIPN--------SSETTSVTDDPEPSTSSVVKRSLRKREADSSQPDEAAKRKQRQDVEKS 1913
               :|.|.|        ......:..|.........|.|:|:...|::..|...:.......:
Human  1944 YRKESDIENFLGFYLWMKIHPYLLQTDKNVFREENNKASMRQNLIDNAIGDIFDQFYFSNTFD-- 2006

  Fly  1914 LTGKKEQVKPARRRQLAEVEERPSLKRSKTESEAKSTVQGKYIS--IIGNETIMSSTTAPIRETN 1976
            |.||:.:.|   |.....:||..:||:.:.:.:.:..:...:.|  ::||  :.|:|.....:||
Human  2007 LMGKRRKQK---RINFLGLEEEGNLKKFQPDLKERFCMNFLHTSLLVVGN--VDSNTQDLSGQTN 2066

  Fly  1977  1976
            Human  2067  2066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-HP2	NP_610972.2	MDN1	<596..845	CDD:227596	42/264 (16%)
		PTZ00449	<739..1091	CDD:185628	67/401 (17%)
		PTZ00108	<1132..1374	CDD:240271	59/306 (19%)
		PTZ00121	<1720..>2291	CDD:173412	56/287 (20%)
RP1	XP_016869210.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900