Protein Alignment: Sin1 and Mapkap1

• Sequence 1: NP_610963.1
• Gene: Sin1
• FlyBaseID: FBgn0033935
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_001277554.1
• Gene: Mapkap1
• MGIID: 2444554
• Length: 522
• Species: Mus musculus
• Alignment Length: 620
• Identity: 162/621 (26%)
• Similarity: 272/621 (44%)
• Gaps: 167/621 (27%)

  Fly     1 MATYSNQHWLLSHIRNSFISTDDTGMCETVMLSDDMPKHYLRKFGNSGAGGDHYHWRRAHKTPPT 65
            ||...|...:|:|||.|.:::|||||||.|::..|:.   |.|.......||     ...:...:
Mouse     1 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVD---LEKTHPPSVPGD-----SGSEVQGS 57

  Fly    66 GGGTTPERNTRHPDAPLQEVDFICYPGLDLSDDEEDMSTHSFDIQMYPEVGAHRFRSNTAQKLEK 130
            .|.|.               .:|....:|:        |.|:|..:       |.||||||:||:
Mouse    58 SGETQ---------------GYIYAQSVDI--------TSSWDFGI-------RRRSNTAQRLER 92

  Fly   131 LDIAKRRAARIKSVNYQE---EVQPPESDDFFKRKELPLSKAERVKNEPKANDDDLSDEGVQSQL 192
            |...::...:.|::.::|   :....|....|::|.|        |.:|.::       |.||.|
Mouse    93 LRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSL--------KEKPPSS-------GKQSIL 142

  Fly   193 TEQLAKSPKQAQNRFIEFARFDGTSQVG-MQTKRINVFLNMLPEPDRNYPLKICVVATAKIQEVI 256
            :.:|.:.|.|..|.|.|:::|||...|| ..||:|:|:|.:....||..|:.:..:|:|::|::|
Mouse   143 SVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLI 207

  Fly   257 GFVCYRTSLQYPDVPLK-SLQHYALYMTEDNDDME-DFPPLDNREPCSKFGFSQLTLAERRPLAP 319
            |.:|::.:.:..:..|. ::..|.|::.||:.::: ||||||:.||..|||||.|.|.|:
Mouse   208 GLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEK----- 267

  Fly   320 VTRVDYHSQ-LGSK-------------SMTSVED-KTALSDAAVKALQNISLNGGTSDPGGGGGG 369
                 |.|. |.||             |:..|:: |..:.:..:||::....:...|.|......
Mouse   268 -----YSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKISGPQYRLEK 327

  Fly   370 GDSPH---------DNVKEYEKRLLNHN--------------------DMLEAPMHRTFRLNIID 405
            ...|:         ::...:|..|:..|                    |||.:..:::|::::|.
Mouse   328 QSEPNIAVDLESTLESQNAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIH 392

  Fly   406 KRFFKSDVTLGISGERIEIDQCKN----AKFWPQKKPVSTPIDFVAHCEILERRHLKALLRIWLK 466
            :..|.:||.|||||:::|||...|    .|||.::||:|...|.:..|::.|.:
Mouse   393 RLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDCDLLCACDLAEEK----------- 446

  Fly   467 SNSSSPSFSTGCTSAPINASVTTLNAGSGSGGIAHSPSSPGHS-SGLFSSSNIRFKHYDFDTDTH 530
                                                  ||.|: ..|...|:..:||..|::|..
Mouse   447 --------------------------------------SPSHAVFKLTYLSSHDYKHLYFESDAA 473

  Fly   531 TAEQIHNKLNCILEMRSSDLRREFLLQRDRKQEKR 565
            |..:|..|:|.|||.|:|..|.::|.|:.||..:|
Mouse   474 TVSEIVLKVNYILESRASTARADYLAQKQRKLNRR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sin1	NP_610963.1	SIN1	18..164	CDD:283156	35/149 (23%)
		CRIM	189..316	CDD:293583	49/130 (38%)
		SIN1_PH	394..545	CDD:293584	39/156 (25%)
Mapkap1	NP_001277554.1	Interaction with NBN. {ECO:0000250}	2..267		95/318 (30%)
		Interaction with MAP3K2. {ECO:0000250}	2..184		65/235 (28%)
		SIN1	18..129	CDD:310193	35/149 (23%)
		CRIM	139..266	CDD:319047	48/127 (38%)
		PH_Avo1	383..490	CDD:270139	40/156 (26%)
		Interaction with ATF2. {ECO:0000250}	468..522		17/42 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C140586466
eggNOG	1	0.900				E1_KOG3739
Hieranoid	1	1.000
Homologene	1	1.000				H11473
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4054
Isobase	1	0.950		0	Normalized mean entropy	S6782
OMA	1	1.010
OrthoDB	1	1.010				D1492466at2759
OrthoFinder	1	1.000				FOG0003784
OrthoInspector	1	1.000				T1083729
orthoMCL	1	0.900				OOG5_134948
Panther	1	1.100			LDO	PTHR13335
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1337
TreeFam	1	0.960
	15	14.750