DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sin1 and Mapkap1

DIOPT Version :9

Sequence 1:NP_610963.1 Gene:Sin1 / 36604 FlyBaseID:FBgn0033935 Length:569 Species:Drosophila melanogaster
Sequence 2:NP_001277554.1 Gene:Mapkap1 / 227743 MGIID:2444554 Length:522 Species:Mus musculus


Alignment Length:620 Identity:162/620 - (26%)
Similarity:272/620 - (43%) Gaps:167/620 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MATYSNQHWLLSHIRNSFISTDDTGMCETVMLSDDMPKHYLRKFGNSGAGGDHYHWRRAHKTPPT 65
            ||...|...:|:|||.|.:::|||||||.|::..|:.   |.|.......||     ...:...:
Mouse     1 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVD---LEKTHPPSVPGD-----SGSEVQGS 57

  Fly    66 GGGTTPERNTRHPDAPLQEVDFICYPGLDLSDDEEDMSTHSFDIQMYPEVGAHRFRSNTAQKLEK 130
            .|.|.               .:|....:|:        |.|:|..:       |.||||||:||:
Mouse    58 SGETQ---------------GYIYAQSVDI--------TSSWDFGI-------RRRSNTAQRLER 92

  Fly   131 LDIAKRRAARIKSVNYQE---EVQPPESDDFFKRKELPLSKAERVKNEPKANDDDLSDEGVQSQL 192
            |...::...:.|::.::|   :....|....|::|.|        |.:|.::       |.||.|
Mouse    93 LRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSL--------KEKPPSS-------GKQSIL 142

  Fly   193 TEQLAKSPKQAQNRFIEFARFDGTSQVG-MQTKRINVFLNMLPEPDRNYPLKICVVATAKIQEVI 256
            :.:|.:.|.|..|.|.|:::|||...|| ..||:|:|:|.:....||..|:.:..:|:|::|::|
Mouse   143 SVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLI 207

  Fly   257 GFVCYRTSLQYPDVPLK-SLQHYALYMTEDNDDME-DFPPLDNREPCSKFGFSQLTLAERRPLAP 319
            |.:|::.:.:..:..|. ::..|.|::.||:.::: ||||||:.||..|||||.|.|.|:     
Mouse   208 GLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEK----- 267

  Fly   320 VTRVDYHSQ-LGSK-------------SMTSVED-KTALSDAAVKALQNISLNGGTSDPGGGGGG 369
                 |.|. |.||             |:..|:: |..:.:..:||::....:...|.|......
Mouse   268 -----YSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKISGPQYRLEK 327

  Fly   370 GDSPH---------DNVKEYEKRLLNHN--------------------DMLEAPMHRTFRLNIID 405
            ...|:         ::...:|..|:..|                    |||.:..:::|::::|.
Mouse   328 QSEPNIAVDLESTLESQNAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIH 392

  Fly   406 KRFFKSDVTLGISGERIEIDQCKN----AKFWPQKKPVSTPIDFVAHCEILERRHLKALLRIWLK 466
            :..|.:||.|||||:::|||...|    .|||.::||:|...|.:..|::.|.:           
Mouse   393 RLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDCDLLCACDLAEEK----------- 446

  Fly   467 SNSSSPSFSTGCTSAPINASVTTLNAGSGSGGIAHSPSSPGHS-SGLFSSSNIRFKHYDFDTDTH 530
                                                  ||.|: ..|...|:..:||..|::|..
Mouse   447 --------------------------------------SPSHAVFKLTYLSSHDYKHLYFESDAA 473

  Fly   531 TAEQIHNKLNCILEMRSSDLRREFLLQRDRKQEKR 565
            |..:|..|:|.|||.|:|..|.::|.|:.||..:|
Mouse   474 TVSEIVLKVNYILESRASTARADYLAQKQRKLNRR 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sin1NP_610963.1 SIN1 18..164 CDD:283156 35/148 (24%)
CRIM 189..316 CDD:293583 49/129 (38%)
SIN1_PH 394..545 CDD:293584 38/155 (25%)
Mapkap1NP_001277554.1 Interaction with NBN. /evidence=ECO:0000250 2..267 94/317 (30%)
Interaction with MAP3K2. /evidence=ECO:0000250 2..184 65/234 (28%)
SIN1 18..129 CDD:368434 35/148 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..59 4/25 (16%)
CRIM 140..266 CDD:374917 47/125 (38%)
PH_Avo1 383..490 CDD:270139 39/155 (25%)
Interaction with ATF2. /evidence=ECO:0000250 468..522 17/41 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167839552
Domainoid 1 1.000 94 1.000 Domainoid score I7510
eggNOG 1 0.900 - - E1_KOG3739
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H11473
Inparanoid 1 1.050 173 1.000 Inparanoid score I4080
Isobase 1 0.950 - 0 Normalized mean entropy S6782
OMA 1 1.010 - - QHG46995
OrthoDB 1 1.010 - - D1492466at2759
OrthoFinder 1 1.000 - - FOG0004857
OrthoInspector 1 1.000 - - oto91973
orthoMCL 1 0.900 - - OOG6_100876
Panther 1 1.100 - - LDO PTHR13335
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1337
SonicParanoid 1 1.000 - - X5980
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1817.750

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