DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sin1 and Mapkap1

DIOPT Version :10

Sequence 1:NP_610963.1 Gene:Sin1 / 36604 FlyBaseID:FBgn0033935 Length:569 Species:Drosophila melanogaster
Sequence 2:NP_796319.1 Gene:Mapkap1 / 227743 MGIID:2444554 Length:522 Species:Mus musculus


Alignment Length:620 Identity:162/620 - (26%)
Similarity:272/620 - (43%) Gaps:167/620 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MATYSNQHWLLSHIRNSFISTDDTGMCETVMLSDDMPKHYLRKFGNSGAGGDHYHWRRAHKTPPT 65
            ||...|...:|:|||.|.:::|||||||.|::..|:.   |.|.......||     ...:...:
Mouse     1 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVD---LEKTHPPSVPGD-----SGSEVQGS 57

  Fly    66 GGGTTPERNTRHPDAPLQEVDFICYPGLDLSDDEEDMSTHSFDIQMYPEVGAHRFRSNTAQKLEK 130
            .|.|.               .:|....:|:        |.|:|..:       |.||||||:||:
Mouse    58 SGETQ---------------GYIYAQSVDI--------TSSWDFGI-------RRRSNTAQRLER 92

  Fly   131 LDIAKRRAARIKSVNYQE---EVQPPESDDFFKRKELPLSKAERVKNEPKANDDDLSDEGVQSQL 192
            |...::...:.|::.::|   :....|....|::|.|        |.:|.::       |.||.|
Mouse    93 LRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSL--------KEKPPSS-------GKQSIL 142

  Fly   193 TEQLAKSPKQAQNRFIEFARFDGTSQVG-MQTKRINVFLNMLPEPDRNYPLKICVVATAKIQEVI 256
            :.:|.:.|.|..|.|.|:::|||...|| ..||:|:|:|.:....||..|:.:..:|:|::|::|
Mouse   143 SVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLI 207

  Fly   257 GFVCYRTSLQYPDVPLK-SLQHYALYMTEDNDDME-DFPPLDNREPCSKFGFSQLTLAERRPLAP 319
            |.:|::.:.:..:..|. ::..|.|::.||:.::: ||||||:.||..|||||.|.|.|:     
Mouse   208 GLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEK----- 267

  Fly   320 VTRVDYHSQ-LGSK-------------SMTSVED-KTALSDAAVKALQNISLNGGTSDPGGGGGG 369
                 |.|. |.||             |:..|:: |..:.:..:||::....:...|.|......
Mouse   268 -----YSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKISGPQYRLEK 327

  Fly   370 GDSPH---------DNVKEYEKRLLNHN--------------------DMLEAPMHRTFRLNIID 405
            ...|:         ::...:|..|:..|                    |||.:..:::|::::|.
Mouse   328 QSEPNIAVDLESTLESQNAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIH 392

  Fly   406 KRFFKSDVTLGISGERIEIDQCKN----AKFWPQKKPVSTPIDFVAHCEILERRHLKALLRIWLK 466
            :..|.:||.|||||:::|||...|    .|||.::||:|...|.:..|::.|.:           
Mouse   393 RLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDCDLLCACDLAEEK----------- 446

  Fly   467 SNSSSPSFSTGCTSAPINASVTTLNAGSGSGGIAHSPSSPGHS-SGLFSSSNIRFKHYDFDTDTH 530
                                                  ||.|: ..|...|:..:||..|::|..
Mouse   447 --------------------------------------SPSHAVFKLTYLSSHDYKHLYFESDAA 473

  Fly   531 TAEQIHNKLNCILEMRSSDLRREFLLQRDRKQEKR 565
            |..:|..|:|.|||.|:|..|.::|.|:.||..:|
Mouse   474 TVSEIVLKVNYILESRASTARADYLAQKQRKLNRR 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sin1NP_610963.1 SIN1 18..164 CDD:461648 35/148 (24%)
CRIM 190..316 CDD:465326 48/128 (38%)
SIN1_PH 395..545 CDD:465327 38/154 (25%)
Mapkap1NP_796319.1 Interaction with NBN. /evidence=ECO:0000250|UniProtKB:Q9BPZ7 2..267 94/317 (30%)
Interaction with MAP3K2. /evidence=ECO:0000250|UniProtKB:Q9BPZ7 2..184 65/234 (28%)
SIN1 18..129 CDD:461648 35/148 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..59 4/25 (16%)
CRIM 140..266 CDD:465326 47/125 (38%)
SIN1-type RBD. /evidence=ECO:0000255 279..353 10/73 (14%)
PH_Avo1 383..490 CDD:270139 39/155 (25%)
Interaction with ATF2. /evidence=ECO:0000250|UniProtKB:Q9BPZ7 468..522 17/41 (41%)

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