Protein Alignment Sin1 and sinh-1

DIOPT Version :10

• Sequence 1: NP_610963.1
• Gene: Sin1 / 36604
• FlyBaseID: FBgn0033935
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_496596.3
• Gene: sinh-1 / 190339
• WormBaseID: WBGene00013261
• Length: 642
• Species: Caenorhabditis elegans
• Alignment Length: 599
• Identity: 125/599 - (20%)
• Similarity: 209/599 - (34%)
• Gaps: 171/599 - (28%)

  Fly    10 LLSHIRNSFISTDD--TGMCETVMLSDDMPKHYLRKFGNSGAGGDHYHWRRAHKTPPTGGGTTPE 72
            ||:.||:.....||  .|:|..::|:                                     |:
 Worm     9 LLNVIRHELRLEDDDGPGLCSRLLLN-------------------------------------PD 36

  Fly    73 RNTRHPDAPLQEVDFICYPGLDLSDDEEDMSTHSFDIQMYPEVGAHRFRSNTAQKLEKLDIAKRR 137
            |..|....||   ||....| ||.||.:......::|.:|.|....|...|.:       :|.|.
 Worm    37 RKCRAGGLPL---DFRLKNG-DLMDDGDAGFDDIYEIPLYEEPIHTRTLINDS-------LALRT 90

  Fly   138 AARIKSVNYQEEVQPPESDDFFKRKELPLSKAERVKNEPKANDDDLSDEGVQSQLTEQLAKSPKQ 202
            |.:||....::.......|:.|.::|        |...||.   .:|.|  :|.:...|.::...
 Worm    91 AEKIKEEGRRDNFYTGPLDELFVKQE--------VNWPPKT---PISTE--KSAIERYLEENSAN 142

  Fly   203 AQNRFIEFARFDGTSQVGMQTKRINVFLNMLPEPDRNY-PLKICVVATAKIQEVIGFVCYRTSLQ 266
            ..|...|:::|..|:.  ..:::|.:.:.|..:.:..: .|||.|:.||:|:||||:...:..|.
 Worm   143 LNNPLGEYSKFAATTT--DPSRQIEIIIPMSCDEEIGFKTLKIEVLTTARIREVIGYCLLQYYLT 205

  Fly   267 YPDVPLKSLQHYALYMTEDNDDME-DFPPLDNREPCSKFGFSQLTLAERRPLAPVTRVDYHSQLG 330
            :.......:..|..|:.|::.::| :.||||:.:...:.||:.|.|        |:|:..:....
 Worm   206 FDSYLPGEVDDYQFYLAEEDGEIEHELPPLDSSKLVGQVGFTCLGL--------VSRIKKNGNSR 262

  Fly   331 SKSMTSV--EDKTALSDAAVKALQNISLNGGTSDPGGGGGGGDSP------------HDNVKEYE 381
            .|...:|  .||    |..|..:.|:                :.|            .:.|||.|
 Worm   263 QKRAVAVWFVDK----DQYVIEVDNM----------------EKPLRWLRDEAFRLREETVKERE 307

  Fly   382 KRLLNHNDMLEAPMHRTFRLNIIDKRFFKSDVTLGISGER-IEI----DQCKNAKFWPQKKPVST 441
            .......|:.|      :.:..:|....|.|:...||..| :|.    .....|.|.|:.....
 Worm   308 PLFQGLLDIKE------YYMEAVDNFDVKLDLEASISSARSLEFVMIRKNSSRAGFHPRGGRYG- 365

  Fly   442 PIDFVAHCEILERRHLKALLRIWLKSNSSSPSFSTGCTSAPINASVTTLNAGSGS---------- 496
                         |.:.|:|.:.:   .:||..:...|..|.....:...||:.:
 Worm   366 -------------RQMSAMLTLKM---PNSPIAAGPMTPLPTVMEESPAVAGTSNGFGFPKAESC 414

  Fly   497 GGIAHSPSSPGHSSGLFSSSNIRFKHYDFDTDTHTAEQIHN-----KLNCILEMRSSDL------ 550
            |.||.:|....:..|...||.|             .::||.     |.|.|......::
 Worm   415 GAIASTPGVTWNDDGGQLSSFI-------------VQRIHKFKPKWKANLIFRWTCFEIEKYRED 466

  Fly   551 RREFLLQRDRKQEK 564
            |..||.|..:|..|
 Worm   467 RSAFLPQGYQKHTK 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sin1	NP_610963.1	SIN1	18..164	CDD:461648	29/147 (20%)
		CRIM	190..316	CDD:465326	32/127 (25%)
		SIN1_PH	395..545	CDD:465327	32/169 (19%)
sinh-1	NP_496596.3	CRIM	129..263	CDD:465326	34/143 (24%)