Protein Alignment Tfb1 and TFB1

DIOPT Version :10

• Sequence 1: NP_610957.1
• Gene: Tfb1 / 36598
• FlyBaseID: FBgn0033929
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_010597.3
• Gene: TFB1 / 851906
• SGDID: S000002719
• Length: 642
• Species: Saccharomyces cerevisiae
• Alignment Length: 627
• Identity: 133/627 - (21%)
• Similarity: 239/627 - (38%)
• Gaps: 138/627 - (22%)

  Fly     3 TSSEDVLLQMGEV--RYKKGDGTLYVMNERVAWMAEHRDTVTVSHRYADIKTQKISPEGKPKVQL 65
            |..:::.:.:.::  |||  |..:|....|....|:|.:|                |.....|
Yeast    95 TVMDNIKMTLQQIISRYK--DADIYEEKRRREESAQHTET----------------PMSSSSV-- 139

  Fly    66 QVVLHDGNTSTFHFVNRQ-GQAAMLADRDKVKELLQQLLPNFKRKVDKDLEDKNRILVENPNLLQ 129
                 ...|.|.|....| ...|.|.:..|:.:.|.      |.|:..:|:.:..:|..|..|::
Yeast   140 -----TAGTPTPHLDTPQLNNGAPLINTAKLDDSLS------KEKLLTNLKLQQSLLKGNKVLMK 193

  Fly   130 LYKDLVITKVLTSDEFWATHAKDHALKKMGRSQEIGVSGAFLADIKPQTDGCNGLKYNLTSDVIH 194
            ::::.||...|...|||:|.........:..||::|.... |:.|||.....|.:..||:.:.|.
Yeast   194 VFQETVINAGLPPSEFWSTRIPLLRAFALSTSQKVGPYNV-LSTIKPVASSENKVNVNLSREKIL 257

  Fly   195 CIFKTYPAVKRKHFENVPAKMSEAEFWTKFFQSHYFHRDRLTAGTKDIFTECGKI---------- 249
            .||:.||.||:.:.:|||....|.|||.:||.|..|.:.|   |.|.:..:.|.:
Yeast   258 NIFENYPIVKKAYTDNVPKNFKEPEFWARFFSSKLFRKLR---GEKIMQNDRGDVIIDRYLTLDQ 319

  Fly   250 -----DDQALKAAVQQGAGDPLLDLK-KFEDVPLEEG-------------FGSVAGDRNVVNSGN 295
                 ||..|...|::     ::||. ..:|.|:..|             .|:..|..:::...|
Yeast   320 EFDRKDDDMLLHPVKK-----IIDLDGNIQDDPVVRGNRPDFTMQPGVDINGNSDGTVDILKGMN 379

  Fly   296 IVHQNMIKRF-NQHSIMVLKTCANVTSAPSTMTNGTNN--ANGPVSQSAYTN------GMNGKGQ 351
            .:.:.||... |::|...|:..:|:|:......|...|  ....:::|..||      ..|...:
Yeast   380 RLSEKMIMALKNEYSRTNLQNKSNITNDEEDEDNDERNELKIDDLNESYKTNYAIIHLKRNAHEK 444

  Fly   352 ATATATKSSSDQVDKDEPQSKKQRLMEKIHYVDLGDPILEGDDSANGEKAKSKHFELSKVERYLN 416
            .|....|||:|.:...:.:...|::::::..|        .|:..|            |::  ||
Yeast   445 TTDNDAKSSADSIKNADLKVSNQQMLQQLSLV--------MDNLIN------------KLD--LN 487

  Fly   417 GPVQNSMYDNHNDPMSLEEVQYKLVRNSESWLNRNVQRTFICSKAAVNALGELSPGGSMMRGFQE 481
            ..|.|:...|..:...:..::.    |::...:.||.          :|||......|.....:.
Yeast   488 QVVPNNEVSNKINKRVITAIKI----NAKQAKHNNVN----------SALGSFVDNTSQANELEV 538

  Fly   482 QSAGQLVPNDFQRELRHLYLSLSELLKHFWSCFPPTSEE-----------LETKLQRMHETLQRF 535
            :|.   :|.|.....|.|:.:..|.||||:..|....::           |:..:::::|..|..
Yeast   539 KST---LPIDLLESCRMLHTTCCEFLKHFYIHFQSGEQKQASTVKKLYNHLKDCIEKLNELFQDV 600

  Fly   536 KMAKLVPFENRAMHELSPLRSSLT-------QHLNQLLRTAN 570
            .........|.....|.|:.:|:|       ::.|:....:|
Yeast   601 LNGDGESMSNTCTAYLKPVLNSITLATHKYDEYFNEYNNNSN 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tfb1	NP_610957.1	PH_TFIIH	10..104	CDD:270049	19/96 (20%)
		BSD	104..157	CDD:128990	13/52 (25%)
		BSD	182..232	CDD:128990	21/49 (43%)
TFB1	NP_010597.3	PH_TFIIH	9..105	CDD:462521	1/9 (11%)
		BSD	177..225	CDD:461089	11/47 (23%)
		BSD	245..295	CDD:128990	21/49 (43%)