Protein Alignment: Tfb1 and gtf2h1

• Sequence 1: NP_001246321.1
• Gene: Tfb1
• FlyBaseID: FBgn0033929
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: XP_012809948.1
• Gene: gtf2h1
• XenbaseID: XB-GENE-975300
• Length: 556
• Species: Xenopus tropicalis
• Alignment Length: 591
• Identity: 270/592 (46%)
• Similarity: 374/592 (63%)
• Gaps: 58/592 (10%)

  Fly     1 MTTSSEDVLLQMGEVRYKKGDGTLYVMNERVAWMAEHRDTVTVSHRYADIKTQKISPEGKPKVQL 65
            |.||||:|||.:.:||:||.||.||:|.|||||..|.:|..|:||.|||||.|||||:||.||||
 Frog    10 MATSSEEVLLIVKKVRHKKQDGALYLMAERVAWAPEGKDRFTISHMYADIKCQKISPDGKAKVQL 74

  Fly    66 QVVLHDGNTSTFHFVNRQGQAAMLADRDKVKELLQQLLPNFKRKVDKDLEDKNRILVENPNLLQL 130
            |:|||.|.|:.|||.|   .|..:.:||.||||||||||.||||.:|:||:|||:|.|:|.|.||
 Frog    75 QLVLHVGETTNFHFSN---DATAIKERDAVKELLQQLLPKFKRKANKELEEKNRMLKEDPVLFQL 136

  Fly   131 YKDLVITKVLTSDEFWATHAKDHALKK--MGRSQEIGVSGAFLADIKPQTDGCNGLKYNLTSDVI 193
            |||||:::|::::||||.....::|..  :...|::|:|.|||||::|||||||||:||||||:|
 Frog   137 YKDLVVSQVISAEEFWANRLSLNSLDSSVLASKQDVGISAAFLADVRPQTDGCNGLRYNLTSDII 201

  Fly   194 HCIFKTYPAVKRKHFENVPAKMSEAEFWTKFFQSHYFHRDRLTAGTKDIFTECGKIDDQALKAAV 258
            ..||:||||||.|:.||||..|:|.:||.:||||||||||||..|.||:|.||.|:|::.||:.|
 Frog   202 ESIFRTYPAVKLKYAENVPHNMTEKDFWKQFFQSHYFHRDRLNTGAKDLFAECAKMDERGLKSMV 266

  Fly   259 QQGAGDPLLDLKKFEDVPLEEGFG-----SVAGDRNVVNSGNIVHQNMIKRFNQHSIMVLKTCAN 318
            .||..:|:|||...||..||||:|     |.:..:::..:.|..   :|||||.||.|||.....
 Frog   267 SQGVKNPMLDLMALEDKCLEEGYGISSAPSTSSTKSIKENSNAA---IIKRFNHHSAMVLAAGLR 328

  Fly   319 VTSAPSTMTNGTNNANGPVSQSAYTNGMNGKGQATATATKSSSDQVDKDEPQSKKQRLMEKIHYV 383
            ...|.|...:.|::.:|                        :|...|...|..||.:|.|.|.|.
 Frog   329 KDEAQSDQCSETSSTDG------------------------NSRDSDFFLPPVKKVKLQEAIEYE 369

  Fly   384 DLGDPILEGDDSANGEKAKSKHFELSKVERYLNG--PVQNSMYDNHNDPM-SLEEVQYKLVRNSE 445
            ||        |.:||  .|.....|.|.:||.:|  |:|:..|.:..|.: |:..::.::    |
 Frog   370 DL--------DQSNG--MKPLVLNLKKSDRYYHGPTPIQSQQYASSQDILSSIHSIKQQM----E 420

  Fly   446 SWLNRNVQRTFICSKAAVNALGELSPGGSMMRGFQEQSAGQLVPNDFQRELRHLYLSLSELLKHF 510
            ::..|..|  .:.|.||.:....|:|||::|:|..:|:..||||||.|.||:|||:::.|||:||
 Frog   421 NYTPRLTQ--VLSSGAASSTTAALTPGGALMQGVTQQAINQLVPNDIQSELKHLYVAVGELLRHF 483

  Fly   511 WSCFPPTSEELETKLQRMHETLQRFKMAKLVPFENRAMHELSPLRSSLTQHLNQLLRTANSKFAT 575
            |||||..:..||.|:.:|...|:||::.||.||:.:...:.  |.::||.||.::|:||.:||.|
 Frog   484 WSCFPVNTPFLEEKVMKMKSNLERFQVTKLRPFQEKLRKQY--LGTNLTGHLEEMLQTAYTKFHT 546

  Fly   576 WKERKL 581
            |:.|::
 Frog   547 WQSRRM 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tfb1	NP_001246321.1	PH_TFIIH	10..104	CDD:270049	58/94 (62%)
		BSD	104..157	CDD:128990	28/53 (53%)
		BSD	181..234	CDD:281847	38/53 (72%)
gtf2h1	XP_012809948.1	PH_TFIIH	19..111	CDD:270049	59/95 (62%)
		BSD	110..163	CDD:128990	28/53 (53%)
		BSD	190..240	CDD:128990	35/50 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C282656605
eggNOG	1	0.900				E1_KOG2074
Hieranoid	1	1.000
Homologene	1	1.000				H3885
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1300
OMA	1	1.010
OrthoDB	1	1.010				D355210at33208
OrthoFinder	1	1.000				FOG0004045
OrthoInspector	1	1.000				T601349
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1500
TreeFam	1	0.960
	12	11.800