DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tej and tdrd5

DIOPT Version :9

Sequence 1:	NP_610950.2	Gene:	tej / 36590	FlyBaseID:	FBgn0033921	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_021325008.1	Gene:	tdrd5 / 557999	ZFINID:	ZDB-GENE-050208-502	Length:	908	Species:	Danio rerio

Alignment Length:	695	Identity:	155/695 - (22%)
Similarity:	255/695 - (36%)	Gaps:	183/695 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSLVKKVVHSLVVSSPGKLTVEQLMRDYRSEEGCTLPYSKLGFKDAESFLRSIPDTVTVTGH--G 69
            |:.:||.|.||:|||...||.|.|.|||:|..|..:|...|||::....::.:|:.|.:...  |
Zfish     7 LAGLKKDVRSLLVSSKHGLTPEHLRRDYQSMLGFPMPLRLLGFRNVLDMVKEMPEVVRLEYQLDG 71

  Fly    70 QMAWITAVATAKSAHIQKLVRCQKKSKNRGSHKPKYCYASEPSNLVFINESVSKMKNRKAPFPTY 134
            .:. :.|:....:..|::||     ||.| .||||      |:             |||.. |.|
Zfish    72 NII-LKAIGDDTTKGIEELV-----SKQR-DHKPK------PN-------------NRKGK-PGY 109

  Fly   135 QVPRNLKLPVSYPNYNRLLYP---------------------VHTP------------------- 159
                   ..:|||....::.|                     .|.|
Zfish   110 -------FNISYPRLQPVILPRRGQAKPALPAHLRSQLKQLLSHGPVRLSELESRYVAQFGKPLN 167

  Fly   160 -------HIDQMISTG-----QQQSTLRTQ-----------RPS-----FPCNANSKSLKVNDWS 196
                   .|.:|:|..     .|||...:|           :|.     |...:.|...::..:|
Zfish   168 VTQYGFFSISEMLSAAMDFIIMQQSRTGSQLLLRSAVTPQNQPENLMRRFSMQSTSPKQRLAGFS 232

  Fly   197 QK-----DRKQEPSKERNNQKYPKITTENKQEKET-----EEL-AQAFENLSVDVAPTDHQEKLK 250
            .|     :|:.|.|.:.::...|:...|.:..:||     ||| .|..|..:......:.:|||:
Zfish   233 PKASSLPERRPEVSLDPSSVSKPEPVKEEQSFEETVFKLEEELRQQILEKGTAGTVSQELKEKLR 297

  Fly   251 CEIYEDNEDEFVRD-PFIYGEVKEKEDEAVVLAFDAVSEDGFDLLSMTTTQQNAV---------- 304
            ..:.|:.....:.: |..|..:..:|.......|.:|:| ....||.|...|...
Zfish   298 KVVAENGNGISIHNLPTEYQRMHGEELPVSQCGFLSVTE-MVGALSDTLAIQRGTDESESHWMVV 361

  Fly   305 --KPLD--PPEDCLH----YASSDDGEDEN--------AIPAYAVDHRVLDVDYPRDAVRSAFTL 353
              ||:|  |.|..|.    ..||..||.:|        :.|..|.:|.  :.:...|:..|...|
Zfish   362 EFKPIDTQPCEPELSPGDGTTSSPTGELQNPSSRAFYFSCPESAWEHE--ETEPLTDSQESDAEL 424

  Fly   354 PA--RDIESIIELQQRIRVQLVSLV------------------------------NPHNFNF-WI 385
            ..  :.|..::.|...:.|..||.|                              :|..|.. :.
Zfish   425 RVANKTIHQMVNLFPELMVSRVSAVPLDAVRCQKLKPPVHRKERELLPVLVEQTESPSYFYIRFS 489

  Fly   386 YNDDFKDYEAQFANMQTFYESSE-SKNYTMPLFLITTDHLCVVRCTSGWERAKVLGYRSSNNKMT 449
            .|.:.:..|.....|::.|...: ::.|.:|...:....:|.|.....|....|:....|..:
Zfish   490 QNKEARALENMMIEMRSCYSYPDVAERYRLPDAYVRPGQVCCVAPRDMWFYRVVIHEVFSETE-- 552

  Fly   450 IEVELVDIGDIIRVSQQNVKFLIKPFALLPRQCLAGRLAFITQCKSPNWTAEVVNFFHDMILLRL 514
            ::|..||.|||.:|.:.:::||...:|.||.|.:...||.:....: .|.|..|:.|..:...|.
Zfish   553 VKVYYVDYGDITKVERHSLRFLKACYADLPAQAVPAMLAGVRPITN-IWPASAVSCFQRLCCERT 616

  Fly   515 LYAKVEAIKNNTAYLVLVDTESQGHTVNLNRSLIETGWVRRCTSA 559
            |.|.|.:.:.:...|.|.||.:: ..|.::.:||:.|..:.|::|
Zfish   617 LVAGVHSYQEDFLLLFLCDTNTE-EDVYVHLALIQEGHAQPCSAA 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	29/87 (33%)
tej	NP_610950.2	TUDOR	379..488	CDD:278965	25/110 (23%)
tdrd5	XP_021325008.1	LOTUS_1_TDRD5	3..97	CDD:193599	32/96 (33%)
		LOTUS_2_TDRD5	133..202	CDD:193589	9/68 (13%)
		LOTUS_3_TDRD5	289..364	CDD:193590	14/75 (19%)
		TUDOR	472..592	CDD:306940	27/121 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4966
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115068at2759
OrthoFinder	1	1.000	-	-		FOG0006089
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5816
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.730