DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tej and TDRD6

DIOPT Version :9

Sequence 1:	NP_610950.2	Gene:	tej / 36590	FlyBaseID:	FBgn0033921	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001010870.1	Gene:	TDRD6 / 221400	HGNCID:	21339	Length:	2096	Species:	Homo sapiens

Alignment Length:	599	Identity:	116/599 - (19%)
Similarity:	210/599 - (35%)	Gaps:	174/599 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELSLVKKVVHSLVVSSPGKLTVEQLMRDYRSEEGCTLP-YSKLGFKDAESFLRSIPDTVTVTGHG 69
            ||.|.::|..||..|     .:|:.:....:..|..:| .|::..|..:..|......:
Human   193 ELGLARRVPDSLFRS-----LLERYLTAATASVGSGVPVLSRVPLKQKQPGLDYFYPQL------ 246

  Fly    70 QMAWITAVATAKSAHIQKLVRCQKKSKNRGSHKPKYCYASEPSNLVFINESVSKMKNRKAPFPTY 134
            |:....||...:..|..: :.||.:|.::..|:              ::||::
Human   247 QLGVTEAVVITQVCHPHR-IHCQLRSVSQEIHR--------------LSESMA------------ 284

  Fly   135 QVPRNLKLPVSYPNYNRLLYPVHTPHIDQMISTGQQQSTLRTQRPSFPCNANSKSLKVNDWSQKD 199
            ||.|.                        ...||.:.||..|                  |  ::
Human   285 QVYRG------------------------STGTGDENSTSAT------------------W--EE 305

  Fly   200 RKQEPSKE--------RNNQKYPKITTENKQEKETEELAQAFENLSVDVAPTDHQEKLKCEIYED 256
            |::.|.|.        .:...|..:..|..:.:...::      |.||..   .:|.:.|.....
Human   306 REESPDKPGSPCASCGLDGHWYRALLLETFRPQRCAQV------LHVDYG---RKELVSCSSLRY 361

  Fly   257 NEDEFVRDPFI--------------------YGEVKE----KEDEAVV---LAFDAV------SE 288
            ...|:.|.|.:                    .|::|.    |...|.:   .:|:.|      .|
Human   362 LLPEYFRMPVVTYPCALYGLWDGGRGWSRSQVGDLKTLILGKAVNAKIEFYCSFEHVYYVSLYGE 426

  Fly   289 DGFDLLSMTTTQQNAVKPLDPPEDCLHYASSDDGEDENA---IPAYAVDHRVLDVDYPRDAVRSA 350
            ||.:|..:...|...:     .:..|...::::.|.|.:   .||..||..:
Human   427 DGINLNRVFGVQSCCL-----ADRVLQSQATEEEEPETSQSQSPAEEVDEEI------------- 473

  Fly   351 FTLPARDIESI-IELQQRIRVQLVSLVNPHNFNFWIYNDDFKDYEAQFANMQT----FYESSESK 410
             :|||  :.|| :::......|:..:.||.  .|||   ..:.:...|:.:..    || ||.||
Human   474 -SLPA--LRSIRLKMNAFYDAQVEFVKNPS--EFWI---RLRKHNVTFSKLMRRMCGFY-SSASK 529

  Fly   411 NYTMPLFLITTDHLCVVRCTSGWERAKVLGYRSSNNKMTIEVELVDIGDIIRVSQQNVKFLIKPF 475
            ...:.|.....|..||....:|:.||.|    :..:..:::|.|||.|:...|...:|:.|:..|
Human   530 LDGVVLKPEPDDLCCVKWKENGYYRAIV----TKLDDKSVDVFLVDRGNSENVDWYDVRMLLPQF 590

  Fly   476 ALLPRQCLAGRLAFITQCKSPNWTAEVVNFFHDMILLRLLYAKVEAIKNNTAYLVLVDTESQGHT 540
            ..||...:...||.|... ...|:.|.|:||...:|.:.|...: ..|.:..|::.:..||:...
Human   591 RQLPILAVKCTLADIWPL-GKTWSQEAVSFFKKTVLHKELVIHI-LDKQDHQYVIEILDESRTGE 653

  Fly   541 VNLNRSLIETGWVR 554
            .|:::.:.:.|:.:
Human   654 ENISKVIAQAGYAK 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	17/86 (20%)
tej	NP_610950.2	TUDOR	379..488	CDD:278965	29/112 (26%)
TDRD6	NP_001010870.1	TUDOR	<69..133	CDD:278965
		TUDOR	246..380	CDD:278965	32/219 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..316		10/72 (14%)
		TUDOR	314..360	CDD:119391	7/54 (13%)
		TUDOR	483..604	CDD:278965	33/130 (25%)
		TUDOR	541..585	CDD:119391	14/47 (30%)
		TUDOR	770..886	CDD:278965
		TUDOR	821..866	CDD:119391
		TUDOR	982..1102	CDD:278965
		TUDOR	1037..1080	CDD:119391
		TUDOR	1301..1422	CDD:278965
		TUDOR	1356..1401	CDD:119391
		TUDOR	1516..1638	CDD:278965
		TUDOR	1571..>1609	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900