Protein Alignment tej and TDRD5

DIOPT Version :10

• Sequence 1: NP_610950.2
• Gene: tej / 36590
• FlyBaseID: FBgn0033921
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001186014.1
• Gene: TDRD5 / 163589
• HGNCID: 20614
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 694
• Identity: 151/694 - (21%)
• Similarity: 248/694 - (35%)
• Gaps: 186/694 - (26%)

  Fly    10 VKKVVHSLVVSSPGKLTVEQLMRDYRSEEGCTLPYSKLGFKDAESFLRSIPDTVTV-TGHGQMAW 73
            ::|.:.||::|:...|:.::|.::|....|..||...||::.....:..:||.|.| .|.|....
Human    11 LRKEIRSLLISTKDGLSPQELEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVRVCPGAGGTVI 75

  Fly    74 ITAVATAKSAHIQKLVRCQKKS-KNRGS-HKPKYCYASEPSNLVFINESVSKMKNRKAPFPTYQV 136
            :.|:....:..|..||..|:.| |.|.| ||.:....|.|.:    :..| ..:.|.||.....|
Human    76 LKAIPDESTKGIASLVAKQRSSHKLRNSMHKGRPSIYSGPRS----HRRV-PYRGRVAPILPAVV 135

  Fly   137 PRNLK-----LPV-----------------SYPNYNRL-LYPVHTPHIDQMISTGQQQS------ 172
            ...||     .||                 .|..|..| ::.|.....| :||..|.::
Human   136 KSELKDLLALSPVLLSDFEKAFAKRFGRSFQYMQYGFLSMFEVLNAASD-VISVEQTRAGSLLML 199

  Fly   173 --------------------TLRTQRPSF--------PCNANSKSLKVNDWSQKDRKQEPSKE-R 208
                                ..|.::.|:        ||           :||.....||.|: .
Human   200 KKSVTEEKPRGCPAGKIFTQPFRMKQGSYSTGFPVAKPC-----------FSQPTSNMEPPKQIM 253

  Fly   209 NNQKYPKI-TTENKQEKETEELAQ---AFENLSVDVAP-----TDHQEKLKCEIYEDNEDEFVRD 264
            :.:|..|: ..|..:...||:|.|   .|:::...:.|     ::.:.|:|..:.:..|..|:..
Human   254 SMEKTSKLNVVETSRLNHTEKLNQLENTFKSVIAQIGPGGTISSELKHKIKFVVSKFPEGLFISK 318

  Fly   265 PFIYGE-------------------------------VKEKEDEAVVLAFDAVSEDGFDLLSMTT 298
              :.||                               |:.::....:|.|||   |...|..:.:
Human   319 --LLGEYEVIFKEQLSPKKLGFLNVTELVGALSDILHVEFRKGHQDLLVFDA---DKKPLPPVQS 378

  Fly   299 TQQNAVKPL--DPPEDCLHYA----------SSDDGEDENAI---PAYAVDHRVLDV-------- 340
            .::...|..  .||.:.|..|          |....|.:..|   |...|....|.|
Human   379 DKKIEAKACVSSPPRNSLSTAAVKETVWNCPSKKQKEPQQKICKKPNLVVKPLQLQVETNKSELN 443

  Fly   341 ------DYPRDAV--RSAFTLPARDIESIIELQQRIRVQLVSLVNPHNFNFWIYNDDFKD-YEAQ 396
                  |.|.|||  :....||..|..|:      |.|.:..:::|..|...||:.|..: .|..
Human   444 LAMANHDIPPDAVPNKKLCRLPPLDTSSL------IGVFVEYIISPSQFYIRIYSRDSSELLEDM 502

  Fly   397 FANMQTFYESS-ESKNYTMPLFLITTDHLCVVRCTSG--WERA---KVLGYRSSNNKMTIEVELV 455
            ...|:..|.:. .|..|.||...|...|||.||.:..  |.|.   :||      .|..:||...
Human   503 MIEMRRCYSNQLVSDRYVMPECFIQPGHLCCVRISEDKWWYRVIIHRVL------EKQEVEVFYP 561

  Fly   456 DIGDIIRVSQQNVKFLIKPFALLPRQCLAGRLAFITQCKSPNWTAEVVNFFHDMILLRLLYAKVE 520
            |.|:|..|.:.:::||...:..||.|.:...||::...:. :||::.:..|..:..|:.|...|:
Human   562 DFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPVEE-HWTSKAILQFQKLCGLKPLVGVVD 625

  Fly   521 AIKNNTAYLVLVDTES------------QGHTVNLNRSLIETGW 552
            ...:....:.|.||.|            :||.:....::...|:
Human   626 EYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENISSKGF 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	22/83 (27%)
		TUDOR	379..488	CDD:425754	33/115 (29%)
TDRD5	NP_001186014.1	LOTUS_1_TDRD5	4..98	CDD:193599	23/86 (27%)
		LOTUS_2_TDRD5	132..201	CDD:193589	13/69 (19%)
		LOTUS_3_TDRD5	296..369	CDD:193590	11/77 (14%)
		Tudor_TDRD5	476..593	CDD:410490	34/122 (28%)