DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tej and TDRD15

DIOPT Version :9

Sequence 1:	NP_610950.2	Gene:	tej / 36590	FlyBaseID:	FBgn0033921	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001293066.1	Gene:	TDRD15 / 100129278	HGNCID:	45037	Length:	1934	Species:	Homo sapiens

Alignment Length:	571	Identity:	100/571 - (17%)
Similarity:	218/571 - (38%)	Gaps:	116/571 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DGGELSLVKKVVHSLVVSSPGKLTVEQLMRDYRSEEGCTLPYSKLGFKDAESFLRSIPDTVTVT- 66
            ||....|:.:::.......|      .|::..|       |...||.||....::.:.|.:..:
Human   186 DGDSFRLIVEMLEEFPQQMP------DLLQHKR-------PELSLGNKDTSLDIQHVLDKLQPSL 237

  Fly    67 --GHGQMAWITAVATAKSAHIQKLVRCQKKSKNRGSHKPKY----CYASEPSNLVFINESVSKMK 125
              |..:...:::..:....:.| |::...:.:|..:|...:    |..:.|:...|....|::.:
Human   238 SVGSTESVKVSSALSPSKFYCQ-LIKWTPELENLTAHMTLHYDTVCQETSPTCDNFGLLCVARRR 301

  Fly   126 NRKAPFPTYQVPRNLKLPVSYPNYNRLLYPVH--TPHIDQMISTGQQQSTLRTQRPSFPCNANSK 188
            |.       |..|.:...:..||..::.:..:  :..|..:.....:|..:.....||||:
Human   302 NG-------QWHRGILQQLLPPNQVKIWFMDYGSSEAIPSIYVKKLKQDFILVPLFSFPCS---- 355

  Fly   189 SLKVNDWSQKDRKQEPSKERNNQKYPKITTENKQEKETEELAQAFENLSVDVAPTDHQEKLKCEI 253
                                       :|..:..:::    |:.|: ||:      .::.|..::
Human   356 ---------------------------LTCLHSPDRD----ARIFQ-LSI------FKQALLGQV 382

  Fly   254 YEDNEDEFVRDPFIYGEVKEKEDEAVVLAFDAVSEDGFDLLSMTTTQQNAVKPLDPPE--DCLHY 316
            ...:.|.|.:|..:|....:.::..|         :...||....||  .:.|:...:  :.|..
Human   383 VYAHIDWFNKDECLYYVTLQTQESTV---------NSKCLLKTVGTQ--VLCPMSDSKISNILSE 436

  Fly   317 ASSDDGEDENAIPAYAVDHRVLDVDYPRDAVRSAFTL----PARDIESIIELQQRIRVQLVSLVN 377
            .|..|      :.::||:..:.::::..|::.....|    |.:.::  :|::......:..::|
Human   437 TSVSD------VNSFAVESFMGNIEWSIDSLNKKGILKVGFPIKTVQ--MEIEAAYIAFIAYVLN 493

  Fly   378 PHNFNFWI-YNDDFKDYEAQFANMQTFYESSESKNYTMPLFLITTDHLCVVRCTSG--WERA--- 436
            |.  |||: .||...:::....|:..||:..|  |..|.|........|..|.:..  :.||
Human   494 PS--NFWVRTNDHRNEFQEIMKNINKFYDLCE--NDEMILRKPEPGLFCCARYSKDRRFYRAVIT 554

  Fly   437 KVLGYRSSNNKMTIEVELVDIGDIIRVSQQNVKFLIKPFALLPRQCLAGRLAFITQCKSPNWTAE 501
            ::.||:       |.|..:|.|:...:...:||.|:..|..||...:...||.|...:. .||..
Human   555 EINGYK-------INVYFLDYGNTDSIPFFDVKILLPEFCELPALAMCCSLAHIFPVED-LWTKA 611

  Fly   502 VVNFFHDMILLRLLYAKVEAIKNNTAYLVLVDTESQGHTVNLNRSLIETGW 552
            .:::|..::|.:.:..:|.| |.:..|.|.:.:......:::...:::.|:
Human   612 AIDYFKKLVLNKAILLQVIA-KKDDKYTVNIQSVEASENIDVISLMLQAGY 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	13/88 (15%)
tej	NP_610950.2	TUDOR	379..488	CDD:278965	28/114 (25%)
TDRD15	NP_001293066.1	TUDOR	535..580	CDD:119391	10/51 (20%)
		TUDOR	759..867	CDD:278965
		TUDOR	806..848	CDD:119391
		TUDOR	961..1084	CDD:278965
		TUDOR	1017..1062	CDD:119391
		TUDOR	1291..1412	CDD:278965
		TUDOR	1346..1393	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1490..1510
		TUDOR	1524..1641	CDD:278965
		TUDOR	1578..1624	CDD:119391
		TUDOR	1740..1852	CDD:278965
		TUDOR	1784..>1820	CDD:119391
		TUDOR	237..356	CDD:278965	20/157 (13%)
		TUDOR	293..339	CDD:119391	7/52 (13%)
		TUDOR	479..600	CDD:278965	32/131 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900