Protein Alignment Mdr50 and MDL1

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_013289.1
• Gene: MDL1 / 850885
• SGDID: S000004178
• Length: 695
• Species: Saccharomyces cerevisiae
• Alignment Length: 692
• Identity: 207/692 - (29%)
• Similarity: 346/692 - (50%)
• Gaps: 77/692 - (11%)

  Fly    10 KDDVNSRSQYKTNIVLGAKLEDSD--RDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVS 72
            |.::|....::.:.:|.:....||  :.:||.:|....       |:|:.:..|   .:|:|::
Yeast    39 KAEINLIIPHRKHFLLRSIRLQSDIAQGKKSTKPTLKL-------SNANSKSSG---FKDIKRL- 92

  Fly    73 YFQLFRYATKKDRALYV-IGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESG-KSYRADDAI 135
                  :...|..:.|: :.||..:.:...:.|...:.|.|.:...:..|..|.| ||
Yeast    93 ------FVLSKPESKYIGLALLLILISSSVSMAVPSVIGKLLDLASESDGEDEEGSKS------- 144

  Fly   136 STLLLDKVRQFSLQN--TYIG---IIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWY 195
                 :|:..|:.:.  |.:|   ||..|.:...|..........:..:|::..::.|.||..:.
Yeast   145 -----NKLYGFTKKQFFTALGAVFIIGAVANASRIIILKVTGERLVARLRTRTMKAALDQDATFL 204

  Fly   196 DFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLV-AFVGSLVLAFVKGWQLSLVCLTSLPLTFI 259
            |.|:.|::.||::.|.|.:...:.:.|......:: .|||..:::|: .|:|:.|.:...|
Yeast   205 DTNRVGDLISRLSSDASIVAKSVTQNVSDGTRAIIQGFVGFGMMSFL-SWKLTCVMMILAP---- 264

  Fly   260 AMGLVAVATSR----LAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILN 320
            .:|.:|:...|    |:::..|...|...|||..|:..||::|:.||..||..|.:.|.....:.
Yeast   265 PLGAMALIYGRKIRNLSRQLQTSVGGLTKVAEEQLNATRTIQAYGGEKNEVRRYAKEVRNVFHIG 329

  Fly   321 IKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMIT-VFFSVMMGSMNI 384
            :|..:.||:.||........:.......|..::..|       :...|.:.: :.::|..||...
Yeast   330 LKEAVTSGLFFGSTGLVGNTAMLSLLLVGTSMIQSG-------SMTVGELSSFMMYAVYTGSSLF 387

  Fly   385 GMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLT----TIEFKEVEFQYPTRPE 445
            |:::.|.|....| ||.|:||.:.::.|.|.|..|:     :|::    .|.||.|.|.|||||:
Yeast   388 GLSSFYSELMKGA-GAAARVFELNDRKPLIRPTIGK-----DPVSLAQKPIVFKNVSFTYPTRPK 446

  Fly   446 VSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIG 510
            ..|...||:.|..|:.|..|||||.||||...|:.|:||..:|::.|...::::.::...|..||
Yeast   447 HQIFKDLNITIKPGEHVCAVGPSGSGKSTIASLLLRYYDVNSGSIEFGDEDIRNFNLRKYRRLIG 511

  Fly   511 VVGQEPILFATSIYENIRY------GREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQ 569
            .|.|||:||..:|.:||.|      ..:|   :.|..|...||...|:...|.|..|:||.||||
Yeast   512 YVQQEPLLFNGTILDNILYCIPPEIAEQD---DRIRRAIGKANCTKFLANFPDGLQTMVGARGAQ 573

  Fly   570 LSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALE-KVSAGRTTIIVAHRLSTVRR 633
            ||||||||||:|||.:.||.:|:|||||||||:.||..|...|: :|..|.|||.:||||||::.
Yeast   574 LSGGQKQRIALARAFLLDPAVLILDEATSALDSQSEEIVAKNLQRRVERGFTTISIAHRLSTIKH 638

  Fly   634 ADRIVVINK-GEVVESGTHQELMELKDHYFNLVTTQLGEDDG 674
            :.|::|:.| |.|||:|:.::|:.:.:...|.:..:..:::|
Yeast   639 STRVIVLGKHGSVVETGSFRDLIAIPNSELNALLAEQQDEEG 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	195/631 (31%)
MDL1	NP_013289.1	MdlB	82..679	CDD:440747	196/639 (31%)