Protein Alignment Mdr50 and ABCB14

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_174122.1
• Gene: ABCB14 / 839694
• AraportID: AT1G28010
• Length: 1247
• Species: Arabidopsis thaliana
• Alignment Length: 1271
• Identity: 488/1271 - (38%)
• Similarity: 706/1271 - (55%)
• Gaps: 50/1271 - (3%)

  Fly    50 HDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLAN 114
            |.|::...||......|   .||...||..|...|..|..:|.|.....|.|.|...:.|
plant    13 HAETEVKKEEKKKMKKE---SVSLMGLFSAADNVDYFLMFLGGLGTCIHGGTLPLFFVFF----- 69

  Fly   115 DMIDLGGLLES-GKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILT 178
                 ||:|:| ||.....:|||:    :|.|.:|...|:|::.||.:::.:.|:......|...
plant    70 -----GGMLDSLGKLSTDPNAISS----RVSQNALYLVYLGLVNLVSAWIGVACWMQTGERQTAR 125

  Fly   179 IRSKFFRSILHQDMKWYDFN-QSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVK 242
            :|..:.:|||.:|:.::|.. :.......::.|...::|.:.:|....:.||..|:...|:.|:.
plant   126 LRINYLKSILAKDITFFDTEARDSNFIFHISSDAILVQDAIGDKTGHVLRYLCQFIAGFVIGFLS 190

  Fly   243 GWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVA 307
            .|||:|:.|..:||..||.|..|:..|.:::|....||.|..|||..:|.:|||.||.||.|.|.
plant   191 VWQLTLLTLGVVPLIAIAGGGYAIVMSTISEKSEAAYADAGKVAEEVMSQVRTVYAFVGEEKAVK 255

  Fly   308 AYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMIT 372
            :|...:..|..|:.:..:..|:|.||.:..::.::||.|||...||..|       ..:.....|
plant   256 SYSNSLKKALKLSKRSGLAKGLGVGLTYSLLFCAWALLFWYASLLVRHG-------KTNGAKAFT 313

  Fly   373 VFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDG-----EGKKLNEPLTTIE 432
            ...:|:.....:|.|.|.:.|....:.|.|.:|.:|..    |.::.     .|..|...:..||
plant   314 TILNVIYSGFALGQAVPSLSAISKGRVAAANIFKMIGN----NNLESSERLENGTTLQNVVGKIE 374

  Fly   433 FKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNL 497
            |..|.|.||:||.: :...|:..||.|:|.|.|||||.||||.|.:|||||:|::|.:|.:|.::
plant   375 FCGVSFAYPSRPNM-VFENLSFTIHSGKTFAFVGPSGSGKSTIISMVQRFYEPRSGEILLDGNDI 438

  Fly   498 KDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTL 562
            |:|.:.|||.::|:|.|||.||||:|..||..|:|.|..::|..||.||||..|||.||.||:|.
plant   439 KNLKLKWLREQMGLVSQEPALFATTIASNILLGKEKANMDQIIEAAKAANADSFIKSLPNGYNTQ 503

  Fly   563 VGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHR 627
            |||.|.|||||||||||||||::|:|:||||||||||||..||..||.||:.|...||||::|||
plant   504 VGEGGTQLSGGQKQRIAIARAVLRNPKILLLDEATSALDAESEKIVQQALDNVMEKRTTIVIAHR 568

  Fly   628 LSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDE 692
            |||:|..|:|||:..|:|.|:|:|.||:.....|..||..|..|...::.|.   :|::...:..
plant   569 LSTIRNVDKIVVLRDGQVRETGSHSELISRGGDYATLVNCQDTEPQENLRSV---MYESCRSQAG 630

  Fly   693 DEEEIKVLSEDEDEDVMVTDEKNKKKKKKKVKDPNEVKPML-EVMKMNKPEWLQIAVGCISSVIM 756
            .....:|.|......  ..:::.|.:|..|.:|......|: |::|:|.||||...:|.|.:|:.
plant   631 SYSSRRVFSSRRTSS--FREDQEKTEKDSKGEDLISSSSMIWELIKLNAPEWLYALLGSIGAVLA 693

  Fly   757 GCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTE 821
            |....:|::....:|... .......::...::.::.|:.||||......||.||:.:.|||||.
plant   694 GSQPALFSMGLAYVLTTF-YSPFPSLIKREVDKVAIIFVGAGIVTAPIYILQHYFYTLMGERLTS 757

  Fly   822 RLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSM 886
            |:|..:|.|:|..|:.|||...|.||||.:.|:.||..|:.|...|:.||||::|.....:||:.
plant   758 RVRLSLFSAILSNEIGWFDLDENNTGSLTSILAADATLVRSAIADRLSTIVQNLSLTITALALAF 822

  Fly   887 YYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGS-AKTMENCTKLAVEVVSNIRTVASLGREEM 950
            :|.|.:..|..|..| :|||..:...|..|...|. .:.....|.||.|.:|||||||:...|:.
plant   823 FYSWRVAAVVTACFP-LLIAASLTEQLFLKGFGGDYTRAYSRATSLAREAISNIRTVAAFSAEKQ 886

  Fly   951 FHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQA 1015
            ..:.:...|....:.:....|..|..|||::.|.|.:||..::|.:..:......|.|..|....
plant   887 ISEQFTCELSKPTKSALLRGHISGFGYGLSQCLAFCSYALGLWYISVLIKRNETNFEDSIKSFMV 951

  Fly  1016 LIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSI-VDRPGVSRDPWHSEGYVRFDKVKFSY 1079
            |::...|:|..||..|::.||..|..::|..|.|:..| .|:|. ||...|.:|.:.|..|.|:|
plant   952 LLVTAYSVAETLALTPDIVKGTQALGSVFRVLHRETEIPPDQPN-SRLVTHIKGDIEFRNVSFAY 1015

  Fly  1080 PTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNL 1144
            |||.||.:.|.|.|.||.|:.:|:|||||.||||.|.||.||||...|...||..|:::|::.:|
plant  1016 PTRPEIAIFKNLNLRVSAGKSLAVVGPSGSGKSTVIGLIMRFYDPSNGNLCIDGHDIKSVNLRSL 1080

  Fly  1145 RNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGA 1209
            |.:|.:|.|||.||..:|.|||.||:  .|.::.|||.|.|.:|.||||:.:..||.|.:|:||.
plant  1081 RKKLALVQQEPALFSTSIHENIKYGN--ENASEAEIIEAAKAANAHEFISRMEEGYMTHVGDKGV 1143

  Fly  1210 QLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVH 1274
            |||||||||:|||||::::|.::||||||||||..:||.||:|||...:|||||.:||||||:..
plant  1144 QLSGGQKQRVAIARAVLKDPSVLLLDEATSALDTSAEKQVQEALDKLMKGRTTILVAHRLSTIRK 1208

  Fly  1275 SDVIFVFENGLVCEAGDHKQLLA-NRGLYYTLYKLQ 1309
            :|.|.|...|.|.|.|.|::|:: :.|.|..|..||
plant  1209 ADTIVVLHKGKVVEKGSHRELVSKSDGFYKKLTSLQ 1244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	481/1249 (39%)
ABCB14	NP_174122.1	PTZ00265	47..1243	CDD:240339	475/1231 (39%)