Protein Alignment Mdr50 and ABCB12

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_171754.1
• Gene: ABCB12 / 839282
• AraportID: AT1G02530
• Length: 1273
• Species: Arabidopsis thaliana
• Alignment Length: 1295
• Identity: 496/1295 - (38%)
• Similarity: 746/1295 - (57%)
• Gaps: 65/1295 - (5%)

  Fly    52 ESDA-SDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLAND 115
            |.|: |.|...|:..|..|.|..::||.:|...|..|.:.|.|.|:..|:..|..:|:||    |
plant     8 EGDSVSHEHSTSKTDEKAKTVPLYKLFAFADSFDVFLMICGSLGAIGNGVCLPLMTLLFG----D 68

  Fly   116 MIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIR 180
            :||..|..::.|.          ::|.|.:..|:..|:|:..|..::|.:.|:......|...||
plant    69 LIDSFGKNQNNKD----------IVDVVSKVCLKFVYLGLGRLGAAFLQVACWMITGERQAAKIR 123

  Fly   181 SKFFRSILHQDMKWYDF-NQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGW 244
            |.:.::||.||:.::|. ..:|||..||:.|...::|.:.|||..|:..:..|||...|||.|||
plant   124 SNYLKTILRQDIGFFDVETNTGEVVGRMSGDTVHIQDAMGEKVGKFIQLVSTFVGGFALAFAKGW 188

  Fly   245 QLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAY 309
            .|:||.|||:|...:|...:|:..:|.:.:....||.||.|.|..:..||||.:|.||.:.:.:|
plant   189 LLTLVMLTSIPFLAMAGAAMALLVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSY 253

  Fly   310 KERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVF 374
            |:.:.:|...:|::...:|:|.|::.:..::|||||.|:|..::::       :.|..|::|.|.
plant   254 KKYITSAYKSSIQQGFSTGLGLGVMIYVFFSSYALAIWFGGKMILE-------KGYTGGSVINVI 311

  Fly   375 FSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQ 439
            ..|:.|||::|..:|.:.||...:.|..|:|..|::.|.|:..|..||.|.:....||.|:|.|.
plant   312 IIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLGDIRGDIELKDVHFS 376

  Fly   440 YPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINW 504
            ||.||:..|.:..:|.|..|.|.||||.||.||||.|.|::|||||:||.:|.:|.|||:..:.|
plant   377 YPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLIDGINLKEFQLKW 441

  Fly   505 LRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQ 569
            :||:||:|.|||:||::||.|||.||:|:||.:||:.|...||||.||..||:|.||.|||.|.|
plant   442 IRSKIGLVCQEPVLFSSSIMENIAYGKENATLQEIKVATELANAAKFINNLPQGLDTKVGEHGTQ 506

  Fly   570 LSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRA 634
            ||||||||||||||:::||.:||||||||||||.||..||.||::|...|||::|||||||||.|
plant   507 LSGGQKQRIAIARAILKDPRVLLLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRNA 571

  Fly   635 DRIVVINKGEVVESGTHQELMELKDH---YFNLVTTQ---LGED--------------------- 672
            |.|.||:.|::||.|:|.||  |||.   |..|:..|   .|.|
plant   572 DMIAVIHSGKMVEKGSHSEL--LKDSVGAYSQLIRCQEINKGHDAKPSDMASGSSFRNSNLNISR 634

  Fly   673 DGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEK-NKKKKKKKVKDPNEVKPMLEVM 736
            :|||:|.....:.|    ......:.||......|:....:: .:::.....::|.....:..:.
plant   635 EGSVISGGTSSFGN----SSRHHSLNVLGLFAGLDLGSGSQRVGQEETGTTSQEPLRKVSLTRIA 695

  Fly   737 KMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVV 801
            .:||||...:.:|.:.:.|.|...|:|.:|...:::.. .|..|| ::::|..:::.|:..|:..
plant   696 ALNKPEIPVLLLGTVVAAINGAIFPLFGILISRVIEAF-FKPADQ-LKKDSRFWAIIFVALGVTS 758

  Fly   802 GIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQ 866
            .|.:..|:|.|.:||.:|..|::.:.||..:..||:|||:..|.:|::.||||.|||.::...|.
plant   759 LIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSSGTMGARLSTDAALIRALVGD 823

  Fly   867 RIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKL 931
            .:...||:.::.|.|:.::....|.|.|:.|...|.|.|..::|...|...:..:....|..:::
plant   824 ALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGFLQVKFMKGFSADAKSKYEEASQV 888

  Fly   932 AVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGT 996
            |.:.|.:||||||...||...|.|.......::...:.....||.:|.:..::|..||...|...
plant   889 ANDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVKQGFISGLGFGFSFFILFCVYATSFYAAA 953

  Fly   997 WCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSI--VDRPGV 1059
            ..|......|.|||:|..||.|....|:.:..|||:..|...||.:||..:.|:..|  .|..|.
plant   954 RLVEDGKTTFIDVFQVFFALTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGT 1018

  Fly  1060 SRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDV 1124
            ..:  :.:|.:....:.|:||.|..||:.:.|.|.:..|:.:||||.||.||||.|.|:|||||.
plant  1019 VLE--NVKGDIELRHLSFTYPARPGIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDP 1081

  Fly  1125 DEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARN-VTDQEIISACKKSN 1188
            |.|...:|..:::.:.:..||.|:|:|.|||:||:.|||.||:||..:.. .|:.|||:|.:.:|
plant  1082 DSGQITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELAN 1146

  Fly  1189 IHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDAL 1253
            .|:||:::..||||.:||||.|||||||||:|||||:::.|||:||||||||||||||::|||||
plant  1147 AHKFISSIQQGYDTVVGEKGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDAL 1211

  Fly  1254 DAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLL-ANRGLYYTLYKLQSGA 1312
            |.....|||:.:||||||:.::|||.:.:||::.|.|.|:.|: .:.|:|.:|.:|...|
plant  1212 DRVIVNRTTVVVAHRLSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQLHMTA 1271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	488/1271 (38%)
ABCB12	NP_171754.1	PTZ00265	3..1267	CDD:240339	494/1289 (38%)
		MdlB	690..1272	CDD:440747	220/586 (38%)