Protein Alignment Mdr50 and Abcb11

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_113948.1
• Gene: Abcb11 / 83569
• RGDID: 619930
• Length: 1321
• Species: Rattus norvegicus
• Alignment Length: 1319
• Identity: 524/1319 - (39%)
• Similarity: 784/1319 - (59%)
• Gaps: 69/1319 - (5%)

  Fly    43 KSKKKSKHD----ESDASDEED-GSQYHEDVKQ----VSYFQLFRYATKKDRALYVIGLLSAVAT 98
            :|.||...:    |||.|...| .|:..:.:|:    |.:|:|||:::.||..|.::|.:.|:..
  Rat     8 RSVKKFGEENHAFESDGSHNNDKKSRLQDKMKEGDIRVGFFELFRFSSSKDIWLMLMGGVCALLH 72

  Fly    99 GLTTPANSLIFG---------NLANDMIDLGG-------LLESGKSYRADDAISTL--LLD---K 142
            |:..|...:|||         ::....:::.|       ::....|:..:....|:  |:|   :
  Rat    73 GMAQPGILIIFGIMTDIFIKYDIERQELEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDIESE 137

  Fly   143 VRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRM 207
            :.:||.....:|:.:|:..|..|..:......||..:|..:||.|:..::.|:|....||:.||.
  Rat   138 MIKFSGIYAGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRF 202

  Fly   208 NEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLA 272
            .:|:.|:.|.:|:::..|:..:...:..|:|.|.:||:|:||.|...||..|...::.::.::..
  Rat   203 ADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFT 267

  Fly   273 KKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFF 337
            :.|:..||.|..:|:..||.||||.||.||.|||..|::.:|.|:...|.:.|..|...|.:|..
  Rat   268 ELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCL 332

  Fly   338 IYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACA 402
            |:..||||||||..||:.      .|.|..||::.:|..|::.:||||.|:..:|.|.....|..
  Rat   333 IFFCYALAFWYGSTLVLD------EEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAAT 391

  Fly   403 KVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGP 467
            .:|..|::.|.|:.:.|:|.||:.....|||..|.|.||:||:|.||:.|::.|..|:|.||||.
  Rat   392 NIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGS 456

  Fly   468 SGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGRE 532
            ||.||||.:||:||||||..|.:..:|.:::.|:|.|||.:||:|.|||:||:|:|.||||:|||
  Rat   457 SGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGRE 521

  Fly   533 DATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEAT 597
            |||.|:|..||..|||..||..||:.:||||||.|.|:|||||||:||||||||:|:|||||.||
  Rat   522 DATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMAT 586

  Fly   598 SALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYF 662
            ||||..|||:||.||.|:..|.|.|.|||||||||.||.|:....|..||.|||:||:|.|..||
  Rat   587 SALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVYF 651

  Fly   663 NLVTTQ------------LGED--DGSVLSPT---GDIYKN---FDIKDEDEEEIKVLSEDEDED 707
            .|||.|            :|:|  :|..|..|   |. |::   ..|:...:.::.:|:  .|..
  Rat   652 MLVTLQSQGDNAHKETSIMGKDATEGGTLERTFSRGS-YRDSLRASIRQRSKSQLSLLT--HDPP 713

  Fly   708 VMVTDEKNKKKKKKK---VKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGS 769
            :.|.|.|:..|..|.   :.:..|..|:..::|.|.|||..|.||.:|:.|.|...||:::||..
  Rat   714 LAVADHKSSYKDSKDNDVLVEEVEPAPVRRILKYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQ 778

  Fly   770 ILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQ 834
            :|...|:.|.:|. |...:...|:|:|.|.|.....|||.|.|..:||.||:|||...|:|||.|
  Rat   779 LLGTFSLLDKEQQ-RSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQ 842

  Fly   835 EVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAF 899
            ::.||||..|..|.|..||:.||:.||||||.::|.:|.|.:.:...:.::.::.|.|.|:...|
  Rat   843 DIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIF 907

  Fly   900 TPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVE 964
            .||:.::..:|..::........:.:|...::..|.:|||||||.:|.|..|.:.:...|..:.:
  Rat   908 FPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYK 972

  Fly   965 ISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAF 1029
            .:.|..:..||.:..::.:.|.|.:|...||.:.:.:.|:.|..||:|..::.:...::....::
  Rat   973 TAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSY 1037

  Fly  1030 APNMQKGVSAAKTIFTFLRRQP--SIVDRPGVSRDPWHS-EGYVRFDKVKFSYPTRSEIQVLKGL 1091
            .|:..|...:|...|..|.|:|  ::....|   :.|.: :|.:.|...||:||:|.:||||.||
  Rat  1038 TPSYAKAKISAARFFQLLDRKPPINVYSEAG---EKWDNFQGKIDFIDCKFTYPSRPDIQVLNGL 1099

  Fly  1092 ELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPI 1156
            .::|:.||.:|.||.|||||||.|||::||||.|:|..:||..|.:.|::..||:.:|||||||:
  Rat  1100 SVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPV 1164

  Fly  1157 LFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAI 1221
            |||.:|.:||.||||.:.::.:..|:|.|::.:|:|:.:||..|:|.:|.:|:|||.|:||||||
  Rat  1165 LFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAI 1229

  Fly  1222 ARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLV 1286
            |||::|:|||:||||||||||.||||.||.|||.|.||||.|.|||||||:.:||:|.|...|:|
  Rat  1230 ARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVV 1294

  Fly  1287 CEAGDHKQLLANRGLYYTL 1305
            .|.|.|::|:|.:|.||.|
  Rat  1295 IEKGTHEKLMAQKGAYYKL 1313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	515/1288 (40%)
Abcb11	NP_113948.1	PTZ00265	150..1314	CDD:240339	491/1177 (42%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385	651..674		6/22 (27%)