Protein Alignment Mdr50 and ABCB28

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_194275.2
• Gene: ABCB28 / 828650
• AraportID: AT4G25450
• Length: 714
• Species: Arabidopsis thaliana
• Alignment Length: 564
• Identity: 181/564 - (32%)
• Similarity: 281/564 - (49%)
• Gaps: 109/564 - (19%)

  Fly   179 IRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVM---FVHYLVAFVGSLVLAF 240
            :|::.||.:|.|..:::|..:.||:...:..||..:...:.:.:..   |..:...| |::.:.|
plant   181 LRAQIFRRVLIQKAEFFDKYKVGELTGLLTSDLGALNSIVNDNISRDRGFRAFTEVF-GTICILF 244

  Fly   241 VKGWQLSLVCLTSLPLTFIAMGLVAVATSRLA----KKEVTMYAGAAV--------VAEGALSGI 293
            ....||:.|           :||:.:|.|.|.    :..|.:|....:        |:| ..|.|
plant   245 TLSPQLAPV-----------LGLLMLAVSVLVAVYKRSTVPVYKSHGLAQATMSDCVSE-TFSAI 297

  Fly   294 RTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYG--------- 349
            |||::|.||.::::.:..:::|.|:..:|...|..|...:....:|.|....:..|
plant   298 RTVRSFSGEKRQMSIFGSQILAYKLSGLKLGTFKSINESITRVAVYISLLALYCLGGSKVKTGEL 362

  Fly   350 -VGLVIK--GYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHI---- 407
             ||.|:.  ||            ..|:.|:|.      |:    :..||..:|..|.:..|
plant   363 AVGTVVSFIGY------------TFTLTFAVQ------GL----VNTFGDLRGTFAAIDRINSIL 405

  Fly   408 ------------IEQIPEINPIDGEGKKL-----------------------NEPLTTIEF---- 433
                        :|:......:..|..||                       ...|.|:.:
plant   406 NAVDIDEALAYGLERDIHTKKVQDENLKLFLSAGPNVNIRHLDKYYMSNLKSTNNLRTLTWAGDV 470

  Fly   434 --KEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTN 496
              .:|.|.||.||:|.:|:.|:|.::.|...||||.||.||||.:||:.|||:|..|.:...|.:
plant   471 CLDDVHFAYPLRPDVKVLDGLSLTLNSGTVTALVGSSGAGKSTIVQLLARFYEPTQGRITVGGED 535

  Fly   497 LKDLDINWLRSRIGVVGQEPILFATSIYENIRYG--REDATREEIEAAAAAANAAIFIKKLPKGY 559
            ::..|.:.....:.:|.|||:||:.|:.|||.||  .|..::::|..||.||||..||..||:||
plant   536 VRMFDKSEWAKVVSIVNQEPVLFSLSVAENIAYGLPNEHVSKDDIIKAAKAANAHDFIISLPQGY 600

  Fly   560 DTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIV 624
            ||||||||..|||||:||:||||:|:::..||:|||||||||..||..||:||.::...|||:::
plant   601 DTLVGERGGLLSGGQRQRVAIARSLLKNAPILILDEATSALDAVSERLVQSALNRLMKDRTTLVI 665

  Fly   625 AHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQ 668
            |||||||:.|::|.|.:.|:::|.|||.||:..|..|.:||.||
plant   666 AHRLSTVQSANQIAVCSDGKIIELGTHSELVAQKGSYASLVGTQ 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	181/564 (32%)
ABCB28	NP_194275.2	MdlB	94..709	CDD:440747	179/562 (32%)