Protein Alignment Mdr50 and ABCB5

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_192092.1
• Gene: ABCB5 / 826974
• AraportID: AT4G01830
• Length: 1230
• Species: Arabidopsis thaliana
• Alignment Length: 1259
• Identity: 491/1259 - (38%)
• Similarity: 742/1259 - (58%)
• Gaps: 52/1259 - (4%)

  Fly    67 DVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRA 131
            :.|.|.:::||.::...|..|.::|.:.|:|.|:.:|..:|:||.|.:.|         |.:...
plant     9 NTKTVPFYKLFFFSDSTDVLLMIVGSIGAIANGVCSPLMTLLFGELIDAM---------GPNQNN 64

  Fly   132 DDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYD 196
            ::     ::::|.:..|...|:|:..|..::|.:.|:......|...|||.:.::||.||:.::|
plant    65 EE-----IVERVSKVCLSLVYLGLGALGAAFLQVACWMITGERQAARIRSLYLKTILRQDIGFFD 124

  Fly   197 FNQ-SGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIA 260
            ... :|||..||:.|...:.|.:.|||..|:..:..|||..|:||::||.|:||.|||:||..::
plant   125 VEMTTGEVVGRMSGDTVLILDAMGEKVGKFIQLISTFVGGFVIAFLRGWLLTLVMLTSIPLLAMS 189

  Fly   261 MGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNM 325
            ...:|:..:|.:.:|...||.|:.|.|..|..||||.:|.||.:.:::|||.:..|...|:|:..
plant   190 GAAIAIIVTRASSQEQAAYAKASNVVEQTLGSIRTVASFTGEKQAMSSYKELINLAYKSNVKQGF 254

  Fly   326 FSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPY 390
            .:|:|.|:::...:::|||..|:|..::::       :.|..|.:|.|..:|:..|:.:|.|:|.
plant   255 VTGLGLGVMFLVFFSTYALGTWFGGEMILR-------KGYTGGAVINVMVTVVSSSIALGQASPC 312

  Fly   391 IEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLK 455
            :.||...|.|..|:|..||:.|.|:..|..||.|.:....||.::|.|.||.||:..:....:|.
plant   313 LTAFTAGKAAAYKMFETIEREPLIDTFDLNGKVLEDIRGEIELRDVCFSYPARPKEEVFGGFSLL 377

  Fly   456 IHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFA 520
            |..|.|.||||.||.||||.|.|::|||||.:|.:|.:|.:||:..:.|:|.:||:|.|||:||:
plant   378 IPSGTTTALVGESGSGKSTVISLIERFYDPNSGQVLIDGVDLKEFQLKWIRGKIGLVSQEPVLFS 442

  Fly   521 TSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALI 585
            :||.|||.||:|.||.|||:||:..||||.||.|||.|.:|||||.|.|||||||||||||||::
plant   443 SSIMENIGYGKEGATVEEIQAASKLANAAKFIDKLPLGLETLVGEHGTQLSGGQKQRIAIARAIL 507

  Fly   586 RDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGT 650
            :||.||||||||||||..||..||.||:::...|||:||||||||||.||.|.||::|::||.|:
plant   508 KDPRILLLDEATSALDAESERVVQEALDRIMVNRTTVIVAHRLSTVRNADIIAVIHRGKIVEEGS 572

  Fly   651 HQELMELKDH---YFNLVTTQ--------LGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDE 704
            |.||  ||||   |..|:..|        |...|||:.|  |....|...: :|::...||....
plant   573 HSEL--LKDHEGAYSQLLRLQEINKESKRLEISDGSISS--GSSRGNNSTR-QDDDSFSVLGLLA 632

  Fly   705 DEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGS 769
            .:|    ..|..::..:||.       ...:..:||||...:.:|.:...:.|...|||.:||..
plant   633 GQD----STKMSQELSQKVS-------FTRIAALNKPEIPILILGTLVGAVNGTIFPIFGILFAK 686

  Fly   770 ILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQ 834
            :::......::  ::.:|..:|:.|::.|:...|......|.|.|||.||..|:|.:.||.::..
plant   687 VIEAFFKAPHE--LKRDSRFWSMIFVLLGVAAVIVYPTTNYLFAIAGGRLIRRIRSMCFEKVVHM 749

  Fly   835 EVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAF 899
            ||.|||:..|.:|::.||||.|||.::...|..:...|:::::|..|:.::....|.:.::.|..
plant   750 EVGWFDEPGNSSGAMGARLSADAALIRTLVGDSLCLSVKNVASLVTGLIIAFTASWEVAIIILVI 814

  Fly   900 TPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVE 964
            .|||.|..|:|...|...:..:....|..:::|.:.|.:||||||...||...:.|.......::
plant   815 IPFIGINGYIQIKFMKGFSADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIK 879

  Fly   965 ISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAF 1029
            ...:.....|:.:|::..:::..||:|.|.|...|......|.|||:|..||.:....|:.|.:|
plant   880 SGIKQGLISGVGFGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQVFLALTLTAVGISQASSF 944

  Fly  1030 APNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELA 1094
            ||:..||..||.:||..:.|...|..|........:.:|.:....:.|:|.||.::||.:.|.|:
plant   945 APDSSKGKGAAVSIFRIIDRISKIDSRDESGMVLENVKGDIELCHISFTYQTRPDVQVFRDLCLS 1009

  Fly  1095 VSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFD 1159
            :..||.:||||.||.||||.|.|:|||||.|.|...:|..:::.:.:..||.|:|:|.|||:||:
plant  1010 IRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLRLKWLRQQMGLVGQEPVLFN 1074

  Fly  1160 RTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARA 1224
            .|||.||:||......|:.|||:|.:.:|.|.||:::..||||.:||:|.|||||||||:|||||
plant  1075 DTIRANIAYGKGGEEATEAEIIAASELANAHRFISSIQKGYDTVVGERGIQLSGGQKQRVAIARA 1139

  Fly  1225 LIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEA 1289
            :::.|||:||||||||||||||:|||||||.....||||.:||||||:.::|||.|.:||::.|.
plant  1140 IVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEK 1204

  Fly  1290 GDHKQLL-ANRGLYYTLYKLQSGA 1312
            |.|:.|: ...|:|.:|.:|...|
plant  1205 GTHETLINIEGGVYASLVQLHINA 1228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	489/1251 (39%)
ABCB5	NP_192092.1	PTZ00265	2..1224	CDD:240339	489/1253 (39%)