Protein Alignment Mdr50 and ABCB21

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_191774.2
• Gene: ABCB21 / 825388
• AraportID: AT3G62150
• Length: 1296
• Species: Arabidopsis thaliana
• Alignment Length: 1347
• Identity: 509/1347 - (37%)
• Similarity: 782/1347 - (58%)
• Gaps: 94/1347 - (6%)

  Fly     3 VKNGDVVKDDVNSRSQYKTNIVLGAKLEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHED 67
            :::.:.:|.|..:|:..:|:   .:|:.:.|......|.:..::|.|.:::  ..|||     |.
plant     5 IESEEGLKVDSPNRADAETS---NSKIHEEDEKELKTESDLKEEKKKTEKN--KQEED-----EK 59

  Fly    68 VKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRAD 132
            .|.|.:.:||.:|...|..|.::|.:.||..||..|..:::||    |:||:     .|::..:.
plant    60 TKTVPFHKLFAFADSFDIILMILGTIGAVGNGLGFPIMTILFG----DVIDV-----FGQNQNSS 115

  Fly   133 DAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDF 197
            |     :.||:.:.:|:..|:|:..||.:.|.::.:..:...|...|||.:.::||.||:.::|.
plant   116 D-----VSDKIAKVALKFVYLGLGTLVAALLQVSGWMISGERQAGRIRSLYLQTILRQDIAFFDV 175

  Fly   198 -NQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAM 261
             ..:|||..||:.|...::|.:.|||...:..:..|:|..|:||.:||.|:||.::|:||..::.
plant   176 ETNTGEVVGRMSGDTVLIQDAMGEKVGKAIQLVSTFIGGFVIAFTEGWLLTLVMVSSIPLLVMSG 240

  Fly   262 GLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMF 326
            ..:|:..|::|.:..|.||.||||.|..:..||||.:|.||.:.::.|.:.:|:|....:.....
plant   241 AALAIVISKMASRGQTSYAKAAVVVEQTVGSIRTVASFTGEKQAISNYNKHLVSAYRAGVFEGAS 305

  Fly   327 SGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYI 391
            :|:|.|.|...|:.:||||.|||..::::       :.|..|.::.:.|:|:.|||::|.|:|.:
plant   306 TGLGLGTLNIVIFCTYALAVWYGGKMILE-------KGYTGGQVLIIIFAVLTGSMSLGQASPCL 363

  Fly   392 EAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKI 456
            .||...:.|..|:|..|::.|||:..|..||.|::....||...|.|.||.|||..|....:|.|
plant   364 SAFAAGQAAAYKMFEAIKRKPEIDASDTTGKVLDDIRGDIELNNVNFSYPARPEEQIFRGFSLSI 428

  Fly   457 HRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFAT 521
            ..|.||||||.||.||||.:.|::||||||:|.:..:|.|||:..:.|:||:||:|.|||:||.:
plant   429 SSGSTVALVGQSGSGKSTVVSLIERFYDPQSGEVRIDGINLKEFQLKWIRSKIGLVSQEPVLFTS 493

  Fly   522 SIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIR 586
            ||.|||.||:|:||.|||..|...|||:.||.|||:|.||:|||.|.|||||||||||:|||:::
plant   494 SIKENIAYGKENATVEEIRKATELANASKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAVARAILK 558

  Fly   587 DPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTH 651
            ||.||||||||||||..||..||.||:::...|||::|||||||||.||.|.||::|::||.|:|
plant   559 DPRILLLDEATSALDAESERIVQEALDRIMVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSH 623

  Fly   652 QELM-ELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKV---------------- 699
            .||: :.:..|..|:  :|.||.......|            ||:::.:
plant   624 SELLRDPEGAYSQLI--RLQEDTKQTEDST------------DEQKLSMESMKRSSLRKSSLSRS 674

  Fly   700 LSEDEDEDVMV-----TDEKNKKKKKKKVKDPNEVK----PMLEVMKMNKPEWLQIAVGCISSVI 755
            ||:......|.     .|..|:...:|.:|....:|    ....|..:||||...:.:|.|::|:
plant   675 LSKRSSSFSMFGFPAGIDTNNEAIPEKDIKVSTPIKEKKVSFFRVAALNKPEIPMLILGSIAAVL 739

  Fly   756 MGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLT 820
            .|..:|||.:|..|:::.. .|..:| ::.::..:::.|::.|:...:....|..||.|||.:|.
plant   740 NGVILPIFGILISSVIKAF-FKPPEQ-LKSDTRFWAIIFMLLGVASMVVFPAQTIFFSIAGCKLV 802

  Fly   821 ERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALS 885
            :|:|.:.||.::|.||.|||:..|.:|::.||||.|||.|:|..|..:...||:::::..|:.::
plant   803 QRIRSMCFEKVVRMEVGWFDETENSSGAIGARLSADAATVRGLVGDALAQTVQNLASVTAGLVIA 867

  Fly   886 MYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEM 950
            ....|.|..:.||..|.|.:..|:....|...:..:.:..|..:::|.:.|.:||||||...||.
plant   868 FVASWQLAFIVLAMLPLIGLNGYIYMKFMVGFSADAKRMYEEASQVANDAVGSIRTVASFCAEEK 932

  Fly   951 FHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQA 1015
            ..:.|.......:....|.....|:.:|::..::|.:|||..|.|...|......|..||:|..|
plant   933 VMKMYKKKCEGPMRTGIRQGIVSGIGFGVSFFVLFSSYAASFYAGARLVDDGKTTFDSVFRVFFA 997

  Fly  1016 LIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVK---- 1076
            |.|...:|:.:.:.:|:..|..:||.:||..:.|:..|        ||....|.| .|.||
plant   998 LTMAAVAISQSSSLSPDSSKASNAAASIFAVIDRESKI--------DPSDESGRV-LDNVKGDIE 1053

  Fly  1077 -----FSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDV 1136
                 |.||:|.::|:.:.|.|::..|:.|||||.||.||||.|.|:|||||.|.|...:|..::
plant  1054 LRHISFKYPSRPDVQIFQDLCLSIRAGKTIALVGESGSGKSTVIALLQRFYDPDSGQITLDGVEI 1118

  Fly  1137 RNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYD 1201
            :.:.:..||.|.|:|||||:||:.|||.||:||... :.|:.||:||.:.||.|.||:.|..|||
plant  1119 KTLQLKWLRQQTGLVSQEPVLFNETIRANIAYGKGG-DATETEIVSAAELSNAHGFISGLQQGYD 1182

  Fly  1202 TRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIA 1266
            |.:||:|.|||||||||:|||||::::||::||||||||||||||:|||||||.....|||:.:|
plant  1183 TMVGERGVQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTVVVA 1247

  Fly  1267 HRLSTVVHSDVIFVFENGLVCEAGDHKQLL-ANRGLYYTLYKLQSGA 1312
            |||||:.::|||.|.:||::.|.|.|:.|: ...|:|.:|.:|...|
plant  1248 HRLSTIKNADVIAVVKNGVIVEKGKHETLINIKDGVYASLVQLHLSA 1294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	494/1275 (39%)
ABCB21	NP_191774.2	MdlB	79..641	CDD:440747	247/584 (42%)
		MdlB	710..1295	CDD:440747	230/597 (39%)