Protein Alignment Mdr50 and ABCB22

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001327523.1
• Gene: ABCB22 / 822471
• AraportID: AT3G28415
• Length: 1229
• Species: Arabidopsis thaliana
• Alignment Length: 1259
• Identity: 470/1259 - (37%)
• Similarity: 707/1259 - (56%)
• Gaps: 68/1259 - (5%)

  Fly    76 LFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLL 140
            :|.:|...|..|..:||:.||..|..||....|.|.|.||:         |.|...|..    .:
plant    10 IFMHANSVDLVLMGLGLIGAVGDGFITPIIFFITGLLLNDI---------GDSSFGDKT----FM 61

  Fly   141 DKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFN--QSGEV 203
            ..:.:.::...|:....||..::...|:......|...:|.|:.|::|.||:.::|.:  .:.:|
plant    62 HAIMKNAVALLYVAGASLVICFVEGYCWTRTGERQASRMREKYLRAVLRQDVGYFDLHVTSTSDV 126

  Fly   204 ASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFI---AMGLVA 265
            .:.::.|...::|.|:||:..|:....|||.|.::.|:..|:|::|......|..|   ..|...
plant   127 ITSVSSDTLVIQDVLSEKLPNFLMSASAFVASYIVGFIMLWRLTIVGFPFFILLLIPGLMCGRAL 191

  Fly   266 VATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIG 330
            :..||..::|   |..|..:||.|:|.:|||.||..|.|.::.:...:..:..|.:::.:..||.
plant   192 INISRKIREE---YNEAGSIAEQAISLVRTVYAFGSERKMISKFSAALEGSVKLGLRQGIAKGIA 253

  Fly   331 FGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFG 395
            .|... ..||.:....|||..:|:       |.....||:..|...:..|..::|.....::.|.
plant   254 IGSNG-VTYAIWGFMTWYGSRMVM-------YHGAKGGTIFAVIICITYGGTSLGRGLSNLKYFS 310

  Fly   396 IAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQ 460
            .|..|..::..:|:::|:|:..:..|:.|......::||.|:|.|.:|||..|.:.|.|:|..|:
plant   311 EAVVAGERIIEVIKRVPDIDSDNPRGQVLENIKGEVQFKHVKFMYSSRPETPIFDDLCLRIPSGK 375

  Fly   461 TVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYE 525
            :|||||.||.||||.|.|:||||||..|.:|.:|.::|.|.:.||||::|:|.|||.||||||.|
plant   376 SVALVGGSGSGKSTVISLLQRFYDPIVGEILIDGVSIKKLQVKWLRSQMGLVSQEPALFATSIEE 440

  Fly   526 NIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEI 590
            ||.:|:|||:.:|:..||.::||..||.:.|.||.|.|||||.|:||||||||:||||:|:.|.:
plant   441 NILFGKEDASFDEVVEAAKSSNAHDFISQFPLGYKTQVGERGVQMSGGQKQRISIARAIIKSPTL 505

  Fly   591 LLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELM 655
            |||||||||||:.||..||.||:..:.|||||::||||||:|..|.|.|...|::||:|:|:|||
plant   506 LLLDEATSALDSESERVVQEALDNATIGRTTIVIAHRLSTIRNVDVICVFKNGQIVETGSHEELM 570

  Fly   656 ELKD-HYFNLVTTQLGE-----DDGSVLSPTGDIYKNF--DIKDEDEEEIKVLS-----EDEDED 707
            |..| .|.:||..|:.|     |:.||....|. :.||  |:|......|:..|     ...|.:
plant   571 ENVDGQYTSLVRLQIMENEESNDNVSVSMREGQ-FSNFNKDVKYSSRLSIQSRSSLFATSSIDTN 634

  Fly   708 VMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQ 772
            :..:..|:||...|:            :|.||||||.....||:|:|:.|...||:|...||::.
plant   635 LAGSIPKDKKPSFKR------------LMAMNKPEWKHALYGCLSAVLYGALHPIYAYASGSMVS 687

  Fly   773 ILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVA 837
            :..:..:|: ::|.:..|.|.|:...::..:.:.:|.|.|...||.||:|:|..:...:|..||:
plant   688 VYFLTSHDE-MKEKTRIYVLLFVGLAVLCFLISIIQQYSFAYMGEYLTKRIRENILSKLLTFEVS 751

  Fly   838 WFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPF 902
            |||:..|.:||:|:||:.||..|:...|:|:..:||:||.:::...|.:...|.|.:|.:|..|.
plant   752 WFDEDENSSGSICSRLAKDANVVRSLVGERVSLLVQTISAVSVACTLGLAISWKLSIVMIAIQPV 816

  Fly   903 ILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISK 967
            ::..||.||.::...:..:.|..:..:|||.|.||||||:.:...:|.     |..|:..|:...
plant   817 VVGCFYTQRIVLKSISKKAIKAQDESSKLAAEAVSNIRTITAFSSQER-----ILKLLKMVQEGP 876

  Fly   968 RNTHFR-----GLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANAL 1027
            :..:.|     |:|...:||||....|...:||...:|...|.....|::....:.....||:|.
plant   877 QRENIRQSWLAGIVLATSRSLMTCTSALNYWYGARLIIDGKITSKAFFELFILFVSTGRVIADAG 941

  Fly  1028 AFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLE 1092
            |...::.||..|..::|..|.|..:|.........|.:.:|.::|..|.|:||||.::.:.|...
plant   942 AMTMDLAKGSDAVGSVFAVLDRYTNIEPEKPDGFVPQNIKGQIKFVNVDFAYPTRPDVIIFKNFS 1006

  Fly  1093 LAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPIL 1157
            :.:.:|:..|:|||||.||||.|.||:||||..:|...||..|:|:..:.:||..:|:|||||||
plant  1007 IDIDEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVKIDGRDIRSYHLRSLRQHIGLVSQEPIL 1071

  Fly  1158 FDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIA 1222
            |..||||||.||..:..:.:.|||.|.|.:|.|:||..|..||||..|::|.|||||||||||||
plant  1072 FAGTIRENIMYGGASDKIDESEIIEAAKAANAHDFIVTLSDGYDTYCGDRGVQLSGGQKQRIAIA 1136

  Fly  1223 RALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVC 1287
            ||:::||.::||||||||||.:||::|||||.....|||::.|||||||:.:.|.|.|.:.|.|.
plant  1137 RAVLKNPSVLLLDEATSALDNQSERMVQDALGRLMVGRTSVVIAHRLSTIQNCDTITVLDKGKVV 1201

  Fly  1288 EAGDHKQLLAN--RGLYYTLYKLQ 1309
            |.|.|..|||.  .|:|::|..||
plant  1202 ECGTHSSLLAKGPTGVYFSLVSLQ 1225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	468/1256 (37%)
ABCB22	NP_001327523.1	MdlB	21..587	CDD:440747	222/589 (38%)
		MdlB	640..1225	CDD:440747	231/602 (38%)