Protein Alignment Mdr50 and ABCB18

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_189480.1
• Gene: ABCB18 / 822468
• AraportID: AT3G28390
• Length: 1225
• Species: Arabidopsis thaliana
• Alignment Length: 1279
• Identity: 477/1279 - (37%)
• Similarity: 701/1279 - (54%)
• Gaps: 113/1279 - (8%)

  Fly    76 LFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLL 140
            :|.:|...|..|..:||:.||..|..||....|...|.|::        .|.|:  ||   ...:
plant    11 IFMHADGVDWMLMALGLIGAVGDGFITPIIFFICSKLLNNV--------GGSSF--DD---ETFM 62

  Fly   141 DKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFN--QSGEV 203
            ..|.:.::...|:.....|..::...|:......|...:|.|:.:::|.||:.::|.:  .:.:|
plant    63 QTVAKNAVALVYVACASWVICFIEGYCWTRTGERQAAKMREKYLKAVLRQDVGYFDLHVTSTSDV 127

  Fly   204 ASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVAT 268
            .:.::.|...::|.|:||:..|:....|||.|.::.|:..|:|::|....:.|..|...:...|.
plant   128 ITSVSSDSLVIQDFLSEKLPNFLMNTSAFVASYIVGFLLLWRLTIVGFPFIILLLIPGLMYGRAL 192

  Fly   269 SRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGL 333
            .|::.|....|..|..:||..:|.:|||.||..|.|.:..:...:..:..|.:::.:..||..|.
plant   193 IRISMKIREEYNEAGSIAEQVISSVRTVYAFGSEKKMIEKFSTALQGSVKLGLRQGLAKGIAIGS 257

  Fly   334 LWFFIYASYALAFWYGVGLVI----KGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAF 394
            .. ..||.:....|||..:|:    ||           ||:.:|...|..|..::|.:...::.|
plant   258 NG-ITYAIWGFLTWYGSRMVMNHGSKG-----------GTVSSVIVCVTFGGTSLGQSLSNLKYF 310

  Fly   395 GIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRG 459
            ..|.....::..:|.::|.|:..:.||:.|.:....:||..|:|.||:|||..|.:.|.|::..|
plant   311 SEAFVVGERIMKVINRVPGIDSDNLEGQILEKTRGEVEFNHVKFTYPSRPETPIFDDLCLRVPSG 375

  Fly   460 QTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIY 524
            :||||||.||.||||.|.|:||||||.||.:|.:|..:..|.:.||||::|:|.|||:||||||.
plant   376 KTVALVGGSGSGKSTVISLLQRFYDPIAGEILIDGLPINKLQVKWLRSQMGLVSQEPVLFATSIK 440

  Fly   525 ENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPE 589
            |||.:|:|||:.:|:..||.|:||..||.:.|..|.|.|||||.|||||||||||||||:|:.|.
plant   441 ENILFGKEDASMDEVVEAAKASNAHSFISQFPNSYQTQVGERGVQLSGGQKQRIAIARAIIKSPI 505

  Fly   590 ILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQEL 654
            ||||||||||||:.||..||.||:..|.|||||::||||||:|.||.|.|::.|.::|:|:|:||
plant   506 ILLLDEATSALDSESERVVQEALDNASIGRTTIVIAHRLSTIRNADVICVVHNGRIIETGSHEEL 570

  Fly   655 ME-LKDHYFNLVTTQ-----------LGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDED 707
            :| |...|.:||..|           :.|...|.||.        |:|...:|.|...|.:
plant   571 LEKLDGQYTSLVRLQQVDNKESDHISVEEGQASSLSK--------DLKYSPKEFIHSTSSN---- 623

  Fly   708 VMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQ 772
             :|.|..|...|..|...|:    ...:|.||:|||.....||:.:.:.|...||::...||::.
plant   624 -IVRDFPNLSPKDGKSLVPS----FKRLMSMNRPEWKHALYGCLGAALFGAVQPIYSYSSGSMVS 683

  Fly   773 ILSVKDNDQYVRENSNQYSLYFLIAGIVVGIA--TFL----QIYFFGIAGERLTERLRGLMFEAM 831
            :..:..:|| ::|.:..|.|.|      ||:|  |||    |.|.|...||.||:|:|..|...:
plant   684 VYFLASHDQ-IKEKTRIYVLLF------VGLALFTFLSNISQHYGFAYMGEYLTKRIRERMLGKI 741

  Fly   832 LRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVA 896
            |..||.|||...|.:|::|:||:.||..|:...|.|:..:||:||.:::..|:.:...|...:|.
plant   742 LTFEVNWFDKDENSSGAICSRLAKDANMVRSLVGDRMSLLVQTISAVSITCAIGLVISWRFSIVM 806

  Fly   897 LAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIP 961
            ::..|.|::.||.||.|:...:..:.|..:..:|||.|.||||||:.:...:|    ..|.:|..
plant   807 MSVQPVIVVCFYTQRVLLKSMSRNAIKGQDESSKLAAEAVSNIRTITAFSSQE----RIINLLKM 867

  Fly   962 AVE----ISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQA-----LI 1017
            ..|    .|.|.:...|::.|.::||:....|...:||       |.|..|...:|:.     ||
plant   868 VQEGPRKDSARQSWLAGIMLGTSQSLITCVSALNFWYG-------GKLIADGKMMSKEFLEIFLI 925

  Fly  1018 MGTAS--IANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYV--------RF 1072
            ..:..  ||.|.....::.||..|..::|..|.|..:|        :|.:.:|||        .|
plant   926 FASTGRVIAEAGTMTKDLVKGSDAVASVFAVLDRNTTI--------EPENPDGYVPKKVKGQISF 982

  Fly  1073 DKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVR 1137
            ..|.|:||||.::.:.:...:.:..|:..|:|||||.||||.|.||:||||..:|...||..|:|
plant   983 SNVDFAYPTRPDVIIFQNFSIDIEDGKSTAIVGPSGSGKSTIISLIERFYDPLKGIVKIDGRDIR 1047

  Fly  1138 NVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDT 1202
            :..:.:||..:.:|||||.||..||||||.||..:..:.:.|||.|.|.:|.|:||.:|..||||
plant  1048 SCHLRSLRQHIALVSQEPTLFAGTIRENIMYGGASNKIDESEIIEAAKAANAHDFITSLSNGYDT 1112

  Fly  1203 RMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAH 1267
            ..|::|.|||||||||||||||:::||.::||||||||||::||.||||||:....|||::.|||
plant  1113 CCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSQSESVVQDALERLMVGRTSVVIAH 1177

  Fly  1268 RLSTVVHSDVIFVFENGLVCEAGDHKQLLAN--RGLYYTLYKLQ 1309
            ||||:...|.|.|.|||.|.|.|:|..|||.  :|.|::|..||
plant  1178 RLSTIQKCDTIAVLENGAVVECGNHSSLLAKGPKGAYFSLVSLQ 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	475/1276 (37%)
ABCB18	NP_189480.1	MdlB	1..586	CDD:440747	226/599 (38%)
		MdlB	637..1221	CDD:440747	235/613 (38%)