Protein Alignment Mdr50 and ABCB17

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_189479.1
• Gene: ABCB17 / 822467
• AraportID: AT3G28380
• Length: 1240
• Species: Arabidopsis thaliana
• Alignment Length: 1317
• Identity: 478/1317 - (36%)
• Similarity: 728/1317 - (55%)
• Gaps: 139/1317 - (10%)

  Fly    49 KHDESDASDEEDGSQYHEDVKQV-SYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNL 112
            |.||.::.        .:.:|.. |...:|.:|...|..|..:||:.||..|..||....||..|
plant     3 KEDEKESG--------RDKMKSFGSIRSIFMHADGVDWILMALGLIGAVGDGFITPVVVFIFNTL 59

  Fly   113 ANDMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCS-----YLSITCFNYAA 172
            .|   :||....:.|::..               ::....:.::.:.|.     :|...|:....
plant    60 LN---NLGTSSSNNKTFMQ---------------TISKNVVALLYVACGSWVICFLEGYCWTRTG 106

  Fly   173 HSQILTIRSKFFRSILHQDMKWYDFN--QSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGS 235
            ..|...:|.|:.|::|.||:.::|.:  .:.:|.:.::.|...::|.|:||:..|:....|||.|
plant   107 ERQAARMREKYLRAVLRQDVGYFDLHVTSTSDVITSISSDSLVIQDFLSEKLPNFLMNASAFVAS 171

  Fly   236 LVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFE 300
            .:::|:..|:|::|....:.|..:...:...|...:::|....|..|..:||.|:|.:|||.||.
plant   172 YIVSFILMWRLTIVGFPFIILLLVPGLMYGRALVSISRKIHEQYNEAGSIAEQAISSVRTVYAFG 236

  Fly   301 GEAKEVAAYKERVVAAKILNIKRNMFSGIGFG------LLWFFIYASYALAFWYGVGLVI----K 355
            .|.|.:..:...:..:..|.:::.:..||..|      .:|.|:       .|||..||:    |
plant   237 SENKMIGKFSTALRGSVKLGLRQGLAKGITIGSNGVTHAIWAFL-------TWYGSRLVMNHGSK 294

  Fly   356 GYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGE 420
            |           ||:..|...:..|.:::|.:...::.|..|..|..::..:|:::|:|:....|
plant   295 G-----------GTVFVVISCITYGGVSLGQSLSNLKYFSEAFVAWERILEVIKRVPDIDSNKKE 348

  Fly   421 GKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDP 485
            |:.|......:||..|:|.|.:|||.:|.:.|.|||..|:||||||.||.||||.|.|:||||||
plant   349 GQILERMKGEVEFNHVKFTYLSRPETTIFDDLCLKIPAGKTVALVGGSGSGKSTVISLLQRFYDP 413

  Fly   486 QAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAI 550
            .||.:|.:|.::..|.:|||||::|:|.|||:||||||.|||.:|:|||:.:|:..||.|:||..
plant   414 IAGEILIDGVSIDKLQVNWLRSQMGLVSQEPVLFATSITENILFGKEDASLDEVVEAAKASNAHT 478

  Fly   551 FIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKV 615
            ||.:.|.||.|.|||||.|:|||||||||||||:|:.|:||||||||||||:.||..||.:|:..
plant   479 FISQFPLGYKTQVGERGVQMSGGQKQRIAIARAIIKSPKILLLDEATSALDSESERVVQESLDNA 543

  Fly   616 SAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKD-HYFNLVTTQLGEDDGSVLSP 679
            |.|||||::||||||:|.||.|.||:.|::||:|:|:||::..| .|.:||:.|..|::.|.::.
plant   544 SIGRTTIVIAHRLSTIRNADVICVIHNGQIVETGSHEELLKRIDGQYTSLVSLQQMENEESNVNI 608

  Fly   680 TGDIYKNFDIKDEDEEEIKVLSED----------EDEDVMVTDEKNKKKKKKKVKD--PNEVKPM 732
            ...:.|         :::..||:|          .....:||:          |.|  ||:.:|:
plant   609 NVSVTK---------DQVMSLSKDFKYSQHNSIGSTSSSIVTN----------VSDLIPNDNQPL 654

  Fly   733 L----EVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLY 793
            :    .:|.||:|||.....||:|:.::|...|:.|...||::.:..:..:|| ::|.:..|.|.
plant   655 VPSFTRLMVMNRPEWKHALYGCLSAALVGVLQPVSAYSAGSVISVFFLTSHDQ-IKEKTRIYVLL 718

  Fly   794 FLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAA 858
            |:...|...:....|.|.|...||.||:|:|..|...:|..||.|||...|.:|::|:||:.||.
plant   719 FVGLAIFSFLVNISQHYGFAYMGEYLTKRIREQMLSKILTFEVNWFDIDDNSSGAICSRLAKDAN 783

  Fly   859 AVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAK 923
            .|:...|.|:..:||:||.:.:...:.:...|.|.:|.::..|.|::.||.||.|:...:..::|
plant   784 VVRSMVGDRMSLLVQTISAVIIACIIGLVIAWRLAIVMISVQPLIVVCFYTQRVLLKSLSEKASK 848

  Fly   924 TMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFR----GLVYGLARSLM 984
            ..:..:|||.|.||||||:.:...:|    ..|.:|....|..:|.:..|    |:|.|.:|||:
plant   849 AQDESSKLAAEAVSNIRTITAFSSQE----RIIKLLKKVQEGPRRESVHRSWLAGIVLGTSRSLI 909

  Fly   985 FFAYAACMYYGTWCVIHRGILFGDVFKVSQA-----LIMGTAS--IANALAFAPNMQKGVSAAKT 1042
            ....|...:||       |.|..|...||:|     ||..|..  ||:|.....::.:|:.|..:
plant   910 TCTSALNFWYG-------GRLIADGKIVSKAFFEIFLIFVTTGRVIADAGTMTTDLARGLDAVGS 967

  Fly  1043 IFTFLRRQPSIVDRPGVSRDPWHSEGYV--------RFDKVKFSYPTRSEIQVLKGLELAVSKGQ 1099
            :|..|.|..:|        :|.:.:|||        .|..|.|:||||.::.:.:...:.:.:|:
plant   968 VFAVLDRCTTI--------EPKNPDGYVAEKIKGQITFLNVDFAYPTRPDVVIFENFSIEIDEGK 1024

  Fly  1100 KIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRE 1164
            ..|:||.||.||||.|.||:||||..:|...||..|:|:..:.:||..:.:|||||:||..||||
plant  1025 STAIVGTSGSGKSTIIGLIERFYDPLKGTVKIDGRDIRSYHLRSLRKYISLVSQEPMLFAGTIRE 1089

  Fly  1165 NISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNP 1229
            ||.||..:..:.:.|||.|.|.:|.|:||.:|..||||..|:||.|||||||||||||||:::||
plant  1090 NIMYGGTSDKIDESEIIEAAKAANAHDFITSLSNGYDTNCGDKGVQLSGGQKQRIAIARAVLKNP 1154

  Fly  1230 KIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQ 1294
            .::||||||||||::||:||||||:....|||:|.|||||||:.:.|:|.|...|.:.|:|.|..
plant  1155 SVLLLDEATSALDSKSERVVQDALERVMVGRTSIMIAHRLSTIQNCDMIVVLGKGKIVESGTHSS 1219

  Fly  1295 LLAN--RGLYYTLYKLQ 1309
            ||..  .|.|::|..:|
plant  1220 LLEKGPTGTYFSLAGIQ 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	474/1294 (37%)
ABCB17	NP_189479.1	MdlB	32..600	CDD:440747	226/603 (37%)
		MdlB	657..1236	CDD:440747	230/598 (38%)