Protein Alignment Mdr50 and ABCB16

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_189477.4
• Gene: ABCB16 / 822465
• AraportID: AT3G28360
• Length: 1228
• Species: Arabidopsis thaliana
• Alignment Length: 1279
• Identity: 466/1279 - (36%)
• Similarity: 700/1279 - (54%)
• Gaps: 111/1279 - (8%)

  Fly    76 LFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLL 140
            :|.:|...|..|..:||:.||..|..||....|...|.||.          .|:..:|   ...:
plant    10 IFMHADGVDWMLMGLGLIGAVGDGFITPILFFITAMLLNDF----------GSFSFND---ETFM 61

  Fly   141 DKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFN--QSGEV 203
            ..:.:.:|...|:.....|..:|...|:......|...:|.::.|::|.||:.::|.:  .:.::
plant    62 QPISKNALAMLYVACASWVICFLEGYCWTRTGERQAAKMRERYLRAVLRQDVGYFDLHVTSTSDI 126

  Fly   204 ASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFI---AMGLVA 265
            .:.::.|...::|.|:||:...:....|||||.::.|:..|:|::|....:.|..|   ..|...
plant   127 ITSVSSDSLVIQDFLSEKLPNILMNASAFVGSYIVGFMLLWRLTIVGFPFIILLLIPGLMYGRAL 191

  Fly   266 VATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIG 330
            :..||..::|   |..|..:||.|:|.:|||.||..|.|.:..:.:.:..:..|.:::.:..||.
plant   192 IGISRKIREE---YNEAGSIAEQAISSVRTVYAFVSEKKMIEKFSDALQGSVKLGLRQGLAKGIA 253

  Fly   331 FGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFG 395
            .|... .:||.:....|||..:|:.       ..|..||:.||...|..|...:|.|...::.|.
plant   254 IGSNG-IVYAIWGFLTWYGSRMVMN-------YGYKGGTVSTVTVCVTFGGTALGQALSNLKYFS 310

  Fly   396 IAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQ 460
            .|..|..::..:|:::|:|:..:..|..|......:||..|:.:||:|||..|.:.|.|||..|:
plant   311 EAFVAGERIQKMIKRVPDIDSDNLNGHILETIRGEVEFNNVKCKYPSRPETLIFDDLCLKIPSGK 375

  Fly   461 TVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYE 525
            ||||||.||.||||.|.|:||||||..|::|.:..::.::.:.||||::|:|.|||.||||||.|
plant   376 TVALVGGSGSGKSTVISLLQRFYDPNEGDILIDSVSINNMQVKWLRSQMGMVSQEPSLFATSIKE 440

  Fly   526 NIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEI 590
            ||.:|:|||:.:|:..||.|:||..||.:.|.||.|.|||||..:|||||||||||||||:.|.|
plant   441 NILFGKEDASFDEVVEAAKASNAHNFISQFPHGYQTQVGERGVHMSGGQKQRIAIARALIKSPII 505

  Fly   591 LLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELM 655
            |||||||||||..||..||.||:..|.|||||::||||||:|.||.|.|::.|.:||:|:|.:||
plant   506 LLLDEATSALDLESERVVQEALDNASVGRTTIVIAHRLSTIRNADIICVLHNGCIVETGSHDKLM 570

  Fly   656 ELKDHYFNLV------------TTQLGEDDGSVLSPTGDI-YKNFDIKDEDEEEIKVLSEDEDED 707
            |:...|.:||            .|.:|..:|.|.|...|: |...|:.......|.....|
plant   571 EIDGKYTSLVRLQQMKNEESCDNTSVGVKEGRVSSLRNDLDYNPRDLAHSMSSSIVTNLSD---- 631

  Fly   708 VMVTDEKNKKKKKKKVKDPNEVKPML----EVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFG 768
                            ..|.:.||::    .:|.||:|||.....||:|:.:.|...||:|...|
plant   632 ----------------SIPQDKKPLVPSFKRLMAMNRPEWKHALCGCLSASLGGAVQPIYAYSSG 680

  Fly   769 SILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLR 833
            .::.:..:.:::| ::||:..|.|.|....:.....:..|.|.|...||.||:|:|..|...:|.
plant   681 LMISVFFLTNHEQ-IKENTRIYVLLFFGLALFTFFTSISQQYSFSYMGEYLTKRIREQMLSKILT 744

  Fly   834 QEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALA 898
            .||.|||::.|.:|::|:||:.||..|:...|:|:..:||:|||:.:...:.:...|...:|.::
plant   745 FEVNWFDEEENSSGAICSRLAKDANVVRSLVGERMSLLVQTISTVMVACTIGLVIAWRFTIVMIS 809

  Fly   899 FTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAV 963
            ..|.|::.:|:||.|:...:..:....:..:|||.|.||||||:.:...:|.     |..|:..|
plant   810 VQPVIIVCYYIQRVLLKNMSKKAIIAQDESSKLAAEAVSNIRTITTFSSQER-----IMKLLERV 869

  Fly   964 E-----ISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQA-----LIM 1018
            :     .|.|.:...|::.|..:||:....|...:||       |.|..|...||:|     ||.
plant   870 QEGPRRESARQSWLAGIMLGTTQSLITCTSALNFWYG-------GKLIADGKMVSKAFFELFLIF 927

  Fly  1019 GTA--SIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVK----- 1076
            .|.  :||.|.....::.||.::..::||.|.|:.:|        :|.:.:||: .:|:|
plant   928 KTTGRAIAEAGTMTTDLAKGSNSVDSVFTVLDRRTTI--------EPENPDGYI-LEKIKGQITF 983

  Fly  1077 ----FSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVR 1137
                |:||||..:.:.....:.:.:|:..|:||||..||||.|.||:||||..:|...||..|:|
plant   984 LNVDFAYPTRPNMVIFNNFSIEIHEGKSTAIVGPSRSGKSTVIGLIERFYDPLQGIVKIDGRDIR 1048

  Fly  1138 NVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDT 1202
            :..:.:||..:.:|||||.||..||||||.||..:..:.:.|||.|.|.:|.||||.:|..||||
plant  1049 SYHLRSLRQHMSLVSQEPTLFAGTIRENIMYGRASNKIDESEIIEAGKTANAHEFITSLSDGYDT 1113

  Fly  1203 RMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAH 1267
            ..|::|.||||||||||||||.:::||.|:||||||||||::||:||||||:....|:|::.|||
plant  1114 YCGDRGVQLSGGQKQRIAIARTILKNPSILLLDEATSALDSQSERVVQDALEHVMVGKTSVVIAH 1178

  Fly  1268 RLSTVVHSDVIFVFENGLVCEAGDHKQLLAN--RGLYYTLYKLQ 1309
            ||||:.:.|.|.|.:.|.|.|:|.|..|||.  .|.|::|..||
plant  1179 RLSTIQNCDTIAVLDKGKVVESGTHASLLAKGPTGSYFSLVSLQ 1222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	464/1276 (36%)
ABCB16	NP_189477.4	MdlB	2..586	CDD:440747	226/599 (38%)
		MdlB	637..1222	CDD:440747	227/606 (37%)