Protein Alignment Mdr50 and ABCB15

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_189475.1
• Gene: ABCB15 / 822463
• AraportID: AT3G28345
• Length: 1240
• Species: Arabidopsis thaliana
• Alignment Length: 1287
• Identity: 477/1287 - (37%)
• Similarity: 712/1287 - (55%)
• Gaps: 124/1287 - (9%)

  Fly    76 LFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLL 140
            :|.:|...|..|..:||:.||..|.|||...||...|.|::        .|.|:..|     ..:
plant    23 IFMHADGVDWLLMGLGLIGAVGDGFTTPLVLLITSKLMNNI--------GGSSFNTD-----TFM 74

  Fly   141 DKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFN--QSGEV 203
            ..:.:.|:...|:.....|..:|...|:......|...:|.|:.|::|.||:.::|.:  .:.:|
plant    75 QSISKNSVALLYVACGSWVVCFLEGYCWTRTGERQTARMREKYLRAVLRQDVGYFDLHVTSTSDV 139

  Fly   204 ASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFI---AMGLVA 265
            .:.::.|...::|.|:||:..|:.....||||.::.|:..|:|::|.|..:.|..|   ..|...
plant   140 ITSVSSDSFVIQDVLSEKLPNFLMSASTFVGSYIVGFILLWRLAIVGLPFIVLLVIPGLMYGRAL 204

  Fly   266 VATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIG 330
            ::.||..::|   |..|..|||.|:|.:|||.||.||.|.::.:...:..:..|.||:.:..||.
plant   205 ISISRKIREE---YNEAGFVAEQAISSVRTVYAFSGERKTISKFSTALQGSVKLGIKQGLAKGIT 266

  Fly   331 FG------LLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAP 389
            .|      .:|.|:       .|||..:|:       |.....||:..|..::.:|.:::|....
plant   267 IGSNGITFAMWGFM-------SWYGSRMVM-------YHGAQGGTVFAVAAAIAIGGVSLGGGLS 317

  Fly   390 YIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNL 454
            .::.|..|.....::..:|.::|:|:..:.:|.||.:....:|||.|:|.||:|.|.||.:...|
plant   318 NLKYFFEAASVGERIMEVINRVPKIDSDNPDGHKLEKIRGEVEFKNVKFVYPSRLETSIFDDFCL 382

  Fly   455 KIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILF 519
            ::..|:||||||.||.||||.|.|:||||||.||.:|.:|.::..|.:.||||::|:|.|||.||
plant   383 RVPSGKTVALVGGSGSGKSTVISLLQRFYDPLAGEILIDGVSIDKLQVKWLRSQMGLVSQEPALF 447

  Fly   520 ATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARAL 584
            ||:|.|||.:|:|||:.:::..||.|:||..||.:||.||:|.|||||.|:|||||||||||||:
plant   448 ATTIKENILFGKEDASMDDVVEAAKASNAHNFISQLPNGYETQVGERGVQMSGGQKQRIAIARAI 512

  Fly   585 IRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESG 649
            |:.|.||||||||||||:.||..||.|||..|.|||||::||||||:|.||.|.|:..|.:||:|
plant   513 IKSPTILLLDEATSALDSESERVVQEALENASIGRTTILIAHRLSTIRNADVISVVKNGHIVETG 577

  Fly   650 THQELME-LKDHYFNLV-TTQLGEDD-------GSVLSPTGDIYKNFDIKDEDEEEIKVLSEDED 705
            :|.|||| :...|..|| ..|:.:.|       |.:..|:.||        .:...:..||
plant   578 SHDELMENIDGQYSTLVHLQQIEKQDINVSVKIGPISDPSKDI--------RNSSRVSTLS---- 630

  Fly   706 EDVMVTDEKNKKKKKKKVKDPNEVKPMLE-----------VMKMNKPEWLQIAVGCISSVIMGCA 759
                      :......|..|:.:|.:.|           ::.||.|||.|...||||:.:.|..
plant   631 ----------RSSSANSVTGPSTIKNLSEDNKPQLPSFKRLLAMNLPEWKQALYGCISATLFGAI 685

  Fly   760 MPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLR 824
            .|.:|...||::.:..:..:|: ::|.:..|:|.|:...::..:....|.|.|...||.||:|:|
plant   686 QPAYAYSLGSMVSVYFLTSHDE-IKEKTRIYALSFVGLAVLSFLINISQHYNFAYMGEYLTKRIR 749

  Fly   825 GLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYE 889
            ..|...:|..||.|||...|.:|::|:||:.||..|:...|.|:..:||::|.:.:...:.:...
plant   750 ERMLSKVLTFEVGWFDRDENSSGAICSRLAKDANVVRSLVGDRMALVVQTVSAVTIAFTMGLVIA 814

  Fly   890 WSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQN 954
            |.|.||.:|..|.|::.||.:|.|:...:..:.|..:..:|||.|.|||:||:.:...:|    .
plant   815 WRLALVMIAVQPVIIVCFYTRRVLLKSMSKKAIKAQDESSKLAAEAVSNVRTITAFSSQE----R 875

  Fly   955 YIGMLIPAVEI----SKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQA 1015
            .:.||..|.|.    |.|.:.|.|....:::||....:|...:||       |.|..|.:..::|
plant   876 IMKMLEKAQESPRRESIRQSWFAGFGLAMSQSLTSCTWALDFWYG-------GRLIQDGYITAKA 933

  Fly  1016 L------IMGTAS-IANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGY---- 1069
            |      ::.|.. ||:|.:...::.||..|..::|..|.|..||        ||...:||
plant   934 LFETFMILVSTGRVIADAGSMTTDLAKGSDAVGSVFAVLDRYTSI--------DPEDPDGYETER 990

  Fly  1070 ----VRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATL 1130
                |.|..|.||||||.::.:.|...:.:.:|:..|:|||||.||||.|.||:||||..:|...
plant   991 ITGQVEFLDVDFSYPTRPDVIIFKNFSIKIEEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVK 1055

  Fly  1131 IDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIAN 1195
            ||..|:|:..:.:||..:.:|||||.||..||||||.||..:..:.:.|||.|.|.:|.|:||.:
plant  1056 IDGRDIRSYHLRSLRRHIALVSQEPTLFAGTIRENIIYGGVSDKIDEAEIIEAAKAANAHDFITS 1120

  Fly  1196 LPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGR 1260
            |..||||..|::|.|||||||||||||||:::||.::||||||||||::||:||||||:....||
plant  1121 LTEGYDTYCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSQSERVVQDALERVMVGR 1185

  Fly  1261 TTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLAN--RGLYYTLYKLQS 1310
            |::.|||||||:.:.|.|.|.:.|.:.|.|.|..||:.  .|:|::|..||:
plant  1186 TSVVIAHRLSTIQNCDAIAVLDKGKLVERGTHSSLLSKGPTGIYFSLVSLQT 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	475/1283 (37%)
ABCB15	NP_189475.1	MdlB	32..600	CDD:440747	233/597 (39%)
		PTZ00265	34..1235	CDD:240339	472/1272 (37%)