Protein Alignment Mdr50 and ABCB4

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_182223.1
• Gene: ABCB4 / 819314
• AraportID: AT2G47000
• Length: 1286
• Species: Arabidopsis thaliana
• Alignment Length: 1343
• Identity: 513/1343 - (38%)
• Similarity: 757/1343 - (56%)
• Gaps: 141/1343 - (10%)

  Fly    35 DRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATG 99
            |....|.....|:.|.:|.:....|...:.||..|.|.:::||.:|...|..|.::|.|.::..|
plant    10 DPNILEEVSETKRDKEEEEEVKKTEKKDEEHEKTKTVPFYKLFAFADSFDFLLMILGTLGSIGNG 74

  Fly   100 LTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLS 164
            |..|..:|:||    |:||..|..::..:            |||.:.:|:..::||.....::|.
plant    75 LGFPLMTLLFG----DLIDAFGENQTNTT------------DKVSKVALKFVWLGIGTFAAAFLQ 123

  Fly   165 ITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFN-QSGEVASRMNEDLSKMEDGLAEKVVMFVHY 228
            ::.:..:...|...|||.:.::||.||:.::|.: .:|||..||:.|...::|.:.|||...:..
plant   124 LSGWMISGERQAARIRSLYLKTILRQDIAFFDIDTNTGEVVGRMSGDTVLIQDAMGEKVGKAIQL 188

  Fly   229 LVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGI 293
            |..|||..|:|||:||.|:||.|:|:||..:|..|:|:..::.|.:..|.||.||.|.|..:..|
plant   189 LATFVGGFVIAFVRGWLLTLVMLSSIPLLVMAGALLAIVIAKTASRGQTAYAKAATVVEQTIGSI 253

  Fly   294 RTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVI-KGY 357
            |||.:|.||.:.::.|.:.:|.|....:.....:|:|.|.|:..::.|||||.|||..|:: ||
plant   254 RTVASFTGEKQAISNYNKHLVTAYKAGVIEGGSTGLGLGTLFLVVFCSYALAVWYGGKLILDKG- 317

  Fly   358 HEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGK 422
                   |..|.::.:..:|:.|||::|..:|.:.||...:.|..|:|..||:.|.|:.....||
plant   318 -------YTGGQVLNIIIAVLTGSMSLGQTSPCLSAFAAGQAAAYKMFETIERRPNIDSYSTNGK 375

  Fly   423 KLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQA 487
            .|::....||.|:|.|.||.||:..|....:|.|..|.||||||.||.||||.:.|::|||||||
plant   376 VLDDIKGDIELKDVYFTYPARPDEQIFRGFSLFISSGTTVALVGQSGSGKSTVVSLIERFYDPQA 440

  Fly   488 GNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFI 552
            |::|.:|.|||:..:.|:||:||:|.|||:||..||.:||.||:||||.|||:|||..|||:.|:
plant   441 GDVLIDGINLKEFQLKWIRSKIGLVSQEPVLFTASIKDNIAYGKEDATTEEIKAAAELANASKFV 505

  Fly   553 KKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSA 617
            .|||:|.||:|||.|.|||||||||||:|||:::||.||||||||||||..||..||.||:::..
plant   506 DKLPQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAESERVVQEALDRIMV 570

  Fly   618 GRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKD---HYFNLVTTQLGEDDGSVLSP 679
            .|||::|||||||||.||.|.||::|::||.|:|.||  |||   .|..|:..|
plant   571 NRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHTEL--LKDPEGAYSQLIRLQ----------- 622

  Fly   680 TGDIYKNFDIKDEDE---EEIKVLS---------------------------------------- 701
                    :.|..||   ||.|:.|
plant   623 --------EEKKSDENAAEEQKMSSIESFKQSSLRKSSLGRSLSKGGSSRGNSSRHSFNMFGFPA 679

  Fly   702 -------EDEDEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCA 759
                   :|::||    |....|.:.|||.       :..:..:||||...:.:|.||:...|..
plant   680 GIDGNVVQDQEED----DTTQPKTEPKKVS-------IFRIAALNKPEIPVLILGSISAAANGVI 733

  Fly   760 MPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLR 824
            :|||.:|..|:::  :.....:.::|:::.:::.|::.|....||...|.:||.|||.:|.:|:|
plant   734 LPIFGILISSVIK--AFFQPPKKLKEDTSFWAIIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIR 796

  Fly   825 GLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYE 889
            .:.||.::..||.|||:..|.:|::.||||.|||.::|..|..:...||::|::..|:.::....
plant   797 SMCFEKVVHMEVGWFDEPENSSGTIGARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIAFLAC 861

  Fly   890 WSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQN 954
            |.|..|.||..|.|.:..::....|...:..:.|.....:::|.:.|.:||||||...|:    .
plant   862 WQLAFVVLAMLPLIALNGFLYMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASFCAED----K 922

  Fly   955 YIGMLIPAVEISKRNTHFRGLVYGLARSLMFF----AYAACMYYGTWCVIHRGILFGDVFKVSQA 1015
            .:.|.....|...:|...:|:|.|:.....||    :|||..|.|...|......|..||:|..|
plant   923 VMNMYSKKCEGPMKNGIRQGIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGKTTFDSVFRVFFA 987

  Fly  1016 LIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVK---- 1076
            |.|...:|:.:.:.:|:..|...||.:||..:.|:..|        ||....|.| .|.||
plant   988 LTMAAMAISQSSSLSPDSSKADVAAASIFAIMDRESKI--------DPSVESGRV-LDNVKGDIE 1043

  Fly  1077 -----FSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDV 1136
                 |.||.|.::|:.:.|.|::..|:.:||||.||.||||.|.|:|||||.|.|...:|..::
plant  1044 LRHVSFKYPARPDVQIFQDLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGVEI 1108

  Fly  1137 RNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYD 1201
            :::.:..||.|.|:||||||||:.|||.||:||... :.::.||:|:.:.||.|.||:.|..|||
plant  1109 KSLRLKWLRQQTGLVSQEPILFNETIRANIAYGKGG-DASESEIVSSAELSNAHGFISGLQQGYD 1172

  Fly  1202 TRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIA 1266
            |.:||:|.|||||||||:|||||::::||::||||||||||||||:|||||||.....||||.:|
plant  1173 TMVGERGIQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTIVVA 1237

  Fly  1267 HRLSTVVHSDVIFVFENGLVCEAGDHKQLL-ANRGLYYTLYKL 1308
            |||||:.::|||.|.:||::.|.|.|..|: ...|:|.:|.:|
plant  1238 HRLSTIKNADVIAVVKNGVIVEKGKHDTLINIKDGVYASLVQL 1280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	504/1307 (39%)
ABCB4	NP_182223.1	PTZ00265	46..1280	CDD:240339	503/1305 (39%)
		MdlB	705..1285	CDD:440747	228/599 (38%)