Protein Alignment Mdr50 and ABCB6

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_181480.1
• Gene: ABCB6 / 818533
• AraportID: AT2G39480
• Length: 1407
• Species: Arabidopsis thaliana
• Alignment Length: 1400
• Identity: 438/1400 - (31%)
• Similarity: 691/1400 - (49%)
• Gaps: 190/1400 - (13%)

  Fly    53 SDASDEEDGSQYHE---DVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLAN 114
            :.|.|||:..:..|   ....|.:.|||..|.:.|..|.|.|.::|.|.|...    :::.:...
plant    48 AQADDEEEMEEPEEMEPPPAAVPFSQLFACADRFDWVLMVFGSVAAAAHGTAL----IVYLHYFA 108

  Fly   115 DMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTI 179
            .::.:...........:||..:.||     :.||...||...:.:..::.::|:......|...|
plant   109 KIVQVLAFPTDSDHLISDDQFNRLL-----ELSLTIVYIAGGVFISGWIEVSCWILTGERQTAVI 168

  Fly   180 RSKFFRSILHQDMKWYD-FNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKG 243
            |||:.:.:|:|||.::| :..:|::.|::..|:..::..|:|||..::|.:..|:..|::.||..
plant   169 RSKYVQVLLNQDMSFFDTYGNNGDIVSQVLSDVLLIQSALSEKVGNYIHNMATFISGLIIGFVNC 233

  Fly   244 WQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAA 308
            |:::|:.|.:.|....|.|:..:...|||:.....||.||.:||.|:|.:||:.||..|.....:
plant   234 WEIALITLATGPFIVAAGGISNIFLHRLAENIQDAYAEAASIAEQAVSYVRTLYAFTNETLAKYS 298

  Fly   309 YKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITV 373
            |...:.|.....|..::..|:|.|..:.....|.|:..|.|...||   |..|    :.|.:||.
plant   299 YATSLQATLRYGILISLVQGLGLGFTYGLAICSCAMQLWIGRFFVI---HHRA----NGGEIITA 356

  Fly   374 FFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEF 438
            .|:|::..:.:..||....:|...:.|..::|.:|.:  ..:..:.||..|:.....|||:.|.|
plant   357 LFAVILSGLGLNQAATNFYSFDQGRIAAYRLFEMISR--SSSGTNQEGIILSAVQGNIEFRNVYF 419

  Fly   439 QYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDIN 503
            .|.:|||:.||:...|.:...:.|||||.:|.|||:.|.|::|||||..|.:|.:|.|:|:|.:.
plant   420 SYLSRPEIPILSGFYLTVPAKKAVALVGRNGSGKSSIIPLMERFYDPTLGEVLLDGENIKNLKLE 484

  Fly   504 WLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGA 568
            ||||:||:|.|||.|.:.||.|||.||| |||.::||.||..|:|..||..|.|||:|.||:.|.
plant   485 WLRSQIGLVTQEPALLSLSIRENIAYGR-DATLDQIEEAAKKAHAHTFISSLEKGYETQVGKTGL 548

  Fly   569 QLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRR 633
            .|:..||.:::||||::.||.||||||.|..||..:|..||.||:.:..||:|||:|.|||.:|.
plant   549 TLTEEQKIKLSIARAVLLDPTILLLDEVTGGLDFEAERVVQEALDLLMLGRSTIIIARRLSLIRN 613

  Fly   634 ADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQ------------------------------ 668
            ||.|.|:.:|:::|.|||.||:.|.:.|..|:..:
plant   614 ADYIAVMEEGQLLEMGTHDELINLGNLYAELLKCEEATKLPRRMPVRNYNDSAAFQAERDSSAGR 678

  Fly   669 ---------------------------------------------LGEDDGSVLSPTGDIYKNFD 688
                                                         |||:..|:  ..|:  |...
plant   679 GFQEPSSPKMAKSPSLQRGHNVFRSQELCFNSEESPNDHSPAPEKLGENGSSL--DVGE--KEPT 739

  Fly   689 IKDEDEEEIKV--------------LSEDEDED-----VMVTDEKNKKKKK-------------- 720
            ||.:|..|:::              .|...|.:     ::::|.:|::...
plant   740 IKRQDSFEMRLPELPKIDIQCPQRQKSNGSDPESPISPLLISDPQNERSHSQTFSRPLGHSDDTS 804

  Fly   721 ---KKVKDPNEVKP--MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDND 780
               |..||....:|  ...:.:::.||||...:|.|.:.|.|...|:.|.:...::... .....
plant   805 ASVKVAKDGQHKEPPSFWRLAQLSFPEWLYAVLGSIGAAIFGSFNPLLAYVIALVVTTY-YTSKG 868

  Fly   781 QYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANG 845
            .::||..:::.|.....|||..:|.|||.::|||.||::|||:|.:||.||||.||.|:|::.|.
plant   869 SHLREEVDKWCLIIACMGIVTVVANFLQHFYFGIMGEKMTERVRRMMFSAMLRNEVGWYDEEENS 933

  Fly   846 TGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQ 910
            ..:|..||:.||..|:.|...|:...:|....:.:.|.:.:...|.|.|||||..|.:.::...|
plant   934 PDTLSMRLANDATFVRAAFSNRLSIFIQDSFAVIVAILIGLLLGWRLALVALATLPVLTLSAIAQ 998

  Fly   911 RTLMAKENMGSAKTMENCTKLAVEVVSNIRTVAS-----------------LGREEMFHQNYIGM 958
            :..:|..:.|..:.....:.:..:.|.||.||.:                 :.|:..||    ||
plant   999 KLWLAGFSKGIQEMHRKASLVLEDAVRNIYTVVAFCAGNKVMELYRLQLQRILRQSFFH----GM 1059

  Fly   959 LIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALI------ 1017
            .|             |..:|.::.|:|...|..::|....|..|      ..|:|.||.
plant  1060 AI-------------GFAFGFSQFLLFACNALLLWYTALSVDRR------YMKLSTALTEYMVFS 1105

  Fly  1018 MGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTR 1082
            ..|.::......||.:.|...:..::|..:.|.|:|......:..|.:..|.:....:.|.||||
plant  1106 FATFALVEPFGLAPYILKRRRSLASVFEIIDRVPTIEPDDTSALSPPNVYGSIELKNIDFCYPTR 1170

  Fly  1083 SEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQ 1147
            .|:.||....|.|:.||.:|:||.||.||||.|.||:|:||...|..|:|..|:::.::..||:.
plant  1171 PEVLVLSNFSLKVNGGQTVAVVGVSGSGKSTIISLIERYYDPVAGQVLLDGRDLKSYNLRWLRSH 1235

  Fly  1148 LGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLS 1212
            :|::.||||:|..||||||.|.  ..|.::.|:..|.:.:|.|.||::||.||||.:|.:|.:|:
plant  1236 MGLIQQEPIIFSTTIRENIIYA--RHNASEAEMKEAARIANAHHFISSLPHGYDTHIGMRGVELT 1298

  Fly  1213 GGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEG-RTTISIAHRLSTVVHSD 1276
            .||||||||||.:::|..|:|:|||:|::::||.:|||:|||....| :|||.||||::.:.|.|
plant  1299 QGQKQRIAIARVVLKNAPILLIDEASSSIESESSRVVQEALDTLIMGNKTTILIAHRVAMMRHVD 1363

  Fly  1277 VIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQSG 1311
            .|.|...|.:.|.|.|..|....|||..|.:...|
plant  1364 NIVVLNGGKIVEEGTHDCLAGKNGLYVRLMQPHFG 1398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	432/1376 (31%)
ABCB6	NP_181480.1	MdlB	83..644	CDD:440747	205/579 (35%)
		MdlB	820..1392	CDD:440747	201/597 (34%)