Protein Alignment Mdr50 and TAP2

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_000535.3
• Gene: TAP2 / 6891
• HGNCID: 44
• Length: 703
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 168/513 - (32%)
• Similarity: 267/513 - (52%)
• Gaps: 34/513 - (6%)

  Fly   167 CFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVA 231
            ||.|......|.||.:.|.|:|.||:.::...::||:.||::.|.:.|.:.|.....:.:..||.
Human   213 CFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVK 277

  Fly   232 FVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTV 296
            .||..........:|:|:.|..:|.|..|..:.......:.::.....|.|..|...|:.|::||
Human   278 VVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342

  Fly   297 KAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIK--GYHE 359
            ::|..|..||..|||.:...:.|..:|::...         :|.........||.:::.  |..:
Human   343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERA---------LYLLVRRVLHLGVQMLMLSCGLQQ 398

  Fly   360 PAYENYDAGTMITVFFSVMMGSMNIG---MAAPYIEAFGIAK-GACAKVFHIIEQIPEINPIDGE 420
            ........|:::    |.|:...::|   ....||....::. ||..|||..:::.|.: |..|
Human   399 MQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNL-PSPG- 457

  Fly   421 GKKLNEPLT---TIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRF 482
               ...|.|   .::|::|.|.||.||:..:|..|...:..|:..|||||:|.||||...|:|..
Human   458 ---TLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNL 519

  Fly   483 YDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAAN 547
            |.|..|.:|.:...:...:..:|.|::..|||||:||:.|:..||.||.:....:::.|||.||:
Human   520 YQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAH 584

  Fly   548 AAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAAL 612
            |..||:::..|..|.|||:|:||:.|||||:||||||:|||.:|:|||||||||...|   ||..
Human   585 ADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE---QALQ 646

  Fly   613 EKVSAG-RTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQL 669
            :..|.| ||.:::||||..|:||.:|:|:.:|::.:..   :|.|.:|.|..||..:|
Human   647 DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEGQDLYSRLVQQRL 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	168/513 (33%)
TAP2	NP_000535.3	3a01208	1..697	CDD:273363	165/507 (33%)
		Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196	301..389		22/96 (23%)
		Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196	414..433		3/18 (17%)