Protein Alignment Mdr50 and TAP1

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_000584.3
• Gene: TAP1 / 6890
• HGNCID: 43
• Length: 748
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 182/559 - (32%)
• Similarity: 279/559 - (49%)
• Gaps: 81/559 - (14%)

  Fly   146 FSLQNTYIGIIMLVCSYLSIT---CFNYA---AHSQILTIRSKFFRSILHQDMKWYDFNQSGEVA 204
            |:...|.:.|:.:..:.|...   .:|..   .||.   ::.:.|.::|.|:.:::..||:|.:.
Human   224 FTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSH---LQGEVFGAVLRQETEFFQQNQTGNIM 285

  Fly   205 SRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGW---QLSLVCLTSLPLTFIAMGLVAV 266
            ||:.||.|.:.|.|:|.:.:|:.|||.   .|.|..:..|   .|::|.|.:|||.|:
Human   286 SRVTEDTSTLSDSLSENLSLFLWYLVR---GLCLLGIMLWGSVSLTMVTLITLPLLFL------- 340

  Fly   267 ATSRLAKKEVTMY-----------AGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILN 320
                |.||....|           |.::.||..|||.:.||::|..|..|...::|::...|.||
Human   341 ----LPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLN 401

  Fly   321 IKRNMFSGIGFGLLWFFIYASYALAFW--------YGVGLVIKGYHEPAYENYDAGTMITVFFSV 377
            .|..:               :||:..|        ..||::..|..........:|.::|.....
Human   402 QKEAV---------------AYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQ 451

  Fly   378 MMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPE------INPIDGEGKKLNEPLTTIEFKEV 436
            |..:..:.:..........|.|:..|:|..:::.|.      :.|:..||        .::|::|
Human   452 MQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEG--------LVQFQDV 508

  Fly   437 EFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLD 501
            .|.||.||:|.:|..|...:..|:..|||||:|.||||...|:|..|.|..|.||.:|..|...:
Human   509 SFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYE 573

  Fly   502 INWLRSRIGVVGQEPILFATSIYENIRYG-REDATREEIEAAAAAANAAIFIKKLPKGYDTLVGE 565
            ..:|..::..|||||.:|..|:.|||.|| .:..|.|||.|||..:.|..||..||:||||.|.|
Human   574 HRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDE 638

  Fly   566 RGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAAL----EKVSAGRTTIIVAH 626
            .|:||||||:|.:|:||||||.|.:|:||:||||||..|:.:|:..|    |:.|  |:.:::..
Human   639 AGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYS--RSVLLITQ 701

  Fly   627 RLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLV 665
            .||.|.:||.|:.:..|.:.|.||||:|||.|..|:.:|
Human   702 HLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMV 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	182/559 (33%)
TAP1	NP_000584.3	3a01208	18..740	CDD:273363	181/557 (32%)
		Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196	375..420		13/59 (22%)
		Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196	453..487		4/33 (12%)