Protein Alignment Mdr50 and abcb9

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001119906.1
• Gene: abcb9 / 570148
• ZFINID: ZDB-GENE-050517-12
• Length: 789
• Species: Danio rerio
• Alignment Length: 705
• Identity: 242/705 - (34%)
• Similarity: 359/705 - (50%)
• Gaps: 97/705 - (13%)

  Fly    30 EDSDR--DRKSFEPNKSKKKSK-HDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIG 91
            ||::|  |....|..||.|..| |..|.|                :..:|..|. |||.:|..|.
Zfish   151 EDTERLVDETEDESEKSMKSGKEHTHSGA----------------TIGRLLSYC-KKDSSLLSIA 198

  Fly    92 ----LLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLLDK-VRQFSLQNT 151
                |||||.                          |:...|....||..:::.| :..|:....
Zfish   199 FFFLLLSAVC--------------------------EAFIPYYTGQAIDGIVIQKSMDHFAKPMI 237

  Fly   152 YIGIIMLVCS--------YLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMN 208
            .:.::.||.|        ..|:|   :|..:  :.:|:..|||::||::.::|.|.:|::.||:.
Zfish   238 TLSVLALVSSIAIGFRGGVFSVT---FARLN--IRLRNLLFRSLMHQEIGFFDANHTGDITSRLT 297

  Fly   209 EDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAK 273
            .|.:::.|.:::.|.:|:...|..||..:..|...|:||:|.:...|...:...|......:|.|
Zfish   298 SDTTQVSDLISQNVNLFLRSFVKAVGIFIFMFGMSWKLSVVTIMGFPYIAVVSKLYGEYYKKLTK 362

  Fly   274 KEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFI 338
            :..|..|.|..|||..:|.:|||::|..|.:|...|..|:....:||.|:    .|.:..   |:
Zfish   363 EVQTALAQANKVAEETISAMRTVRSFANEDQEGDMYYSRLQEMFVLNKKQ----AIAYAC---FM 420

  Fly   339 YASYALAFWYGVGLVIKGYHEPAYENYDAGTMIT-VFFSVMMGSMNIGMAAPYIEAFGIAK--GA 400
            ::||.......|.::..|.|.........||:|: |.:.:.:|.....:::.|.   |:.:  ||
Zfish   421 WSSYISELALQVAILFYGGHLVVTNQMSGGTLISFVIYELELGEALESISSVYT---GLMQGVGA 482

  Fly   401 CAKVFHIIEQIPE--INPIDGEGKKLNEPLT-TIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTV 462
            ..|||..|::.|:  :|     |::..|.|. .:||..|.|.||:|||:.:|..::..:..||..
Zfish   483 AEKVFEYIDRKPKHALN-----GQEAPETLEGQVEFNNVTFAYPSRPEMDVLKNVSFSLRPGQVT 542

  Fly   463 ALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENI 527
            |||||||.|||:|:.|::.||.||.|.:|.:|..:......:..|::.:|.|||:|||.::..||
Zfish   543 ALVGPSGGGKSSCVCLLENFYAPQQGQVLVDGRPVNTYQHKYYHSKVALVAQEPVLFARTVQMNI 607

  Fly   528 RYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILL 592
            .||..:|..|.:..||..|||..||..|.||||:.|||:|.|||||||||:||||||||.|.||:
Zfish   608 SYGVPEAPMEAVIRAAINANAHDFITGLSKGYDSGVGEKGTQLSGGQKQRVAIARALIRSPRILI 672

  Fly   593 LDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMEL 657
            |||||||||:.||..||.||..:....|.:::|||||||.|||.|:||:||.|||.|.|.|||..
Zfish   673 LDEATSALDSESEYIVQQALNNLMREHTVLVIAHRLSTVERADNILVIDKGSVVEQGPHAELMAR 737

  Fly   658 KDHYFNLVTTQ-LG-----EDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDE 706
            ...|..||..| ||     :|.....:||      :::|.||:|..:..|:.|.|
Zfish   738 GGLYCKLVQRQILGTEIDVDDKNPSPAPT------WELKTEDKENAEDCSDTEYE 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	230/663 (35%)
abcb9	NP_001119906.1	3a01208	46..745	CDD:273363	227/656 (35%)