Protein Alignment Mdr50 and Abcb10

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_062425.1
• Gene: Abcb10 / 56199
• MGIID: 1860508
• Length: 715
• Species: Mus musculus
• Alignment Length: 615
• Identity: 213/615 - (34%)
• Similarity: 333/615 - (54%)
• Gaps: 32/615 - (5%)

  Fly   710 VTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVG--CISSVIMGCAMPIFAVLFGSILQ 772
            |.|..|..:::......:||..:|.:::..:.. |..|||  .:||||...| |.|   .|.|:.
Mouse   103 VRDLGNDSQRRPAATGRSEVWKLLGLVRPERGR-LSAAVGFLAVSSVITMSA-PFF---LGRIID 162

  Fly   773 ILSVKDNDQY---VRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQ 834
            ::....::.|   :.......:..||......||    ::|....:|:.:..|||..:|.::|||
Mouse   163 VIYTNPSEGYGDSLTRLCAVLTCVFLCGAAANGI----RVYLMQSSGQSIVNRLRTSLFSSILRQ 223

  Fly   835 EVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAF 899
            |||:||  ...||.|..|||.|.|.:..:..:.:...:::.:..::|:.:..:...||....|:.
Mouse   224 EVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSLATFVLSV 286

  Fly   900 TPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVE 964
            .|.|.:...:....:.|.:..:..::...|:||.|.:.||||:.:.|:|....:.|.|.:...::
Mouse   287 VPPISVLAVIYGRYLRKLSKATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTGRVDQLLQ 351

  Fly   965 ISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGD----VFKVSQALIMG---TAS 1022
            ::::....|...:|.|.........:.:|.|       |:|.|.    |.::|..|:..   ..|
Mouse   352 LAQKEALARAGFFGAAGLSGNLIVLSVLYKG-------GLLMGSAHMTVGELSSFLMYAFWVGLS 409

  Fly  1023 IANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQV 1087
            |....:|...:.||:.|...::..|.|||.:....|:..|....:|.:.|..|.|:||.|.|:.|
Mouse   410 IGGLSSFYSELMKGLGAGGRLWELLERQPRLPFNEGMVLDEKTFQGALEFRNVHFTYPARPEVSV 474

  Fly  1088 LKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVS 1152
            .:...|::..|...|||||||.||||.:.|:.|.||.:.|...:|..|:|.::...||:::|.||
Mouse   475 FQDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVS 539

  Fly  1153 QEPILFDRTIRENISYG-DNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQK 1216
            |||:||..::.|||:|| ||..:||.|::..|.:.:|..|||.:.|.|:||.:||||..||||||
Mouse   540 QEPVLFSCSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQK 604

  Fly  1217 QRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVF 1281
            |||||||||::||||:||||||||||||:|.:||:|||...||||.:.|||||||:.:::.:.|.
Mouse   605 QRIAIARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVL 669

  Fly  1282 ENGLVCEAGDHKQLLAN-RGLYYTLYKLQS 1310
            ::|.:||.|.|::||.. .|||..|...||
Mouse   670 DHGKICEHGTHEELLLKPNGLYRKLMNKQS 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	211/611 (35%)
Abcb10	NP_062425.1	MdlB	115..699	CDD:440747	208/601 (35%)