Protein Alignment Mdr50 and mdl1

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_595751.1
• Gene: mdl1 / 2541285
• PomBaseID: SPBC9B6.09C
• Length: 726
• Species: Schizosaccharomyces pombe
• Alignment Length: 717
• Identity: 223/717 - (31%)
• Similarity: 361/717 - (50%)
• Gaps: 98/717 - (13%)

  Fly     2 TVKNGDVVKDDVNSRSQYKTNIVLGAKLEDSDRD-----RKSFEPNKS----KKKSKHDESDASD 57
            |.|....|...:||.||..::   |:|:......     .:|..|.:|    |...:|:.:..|.
pombe    58 TSKLSSQVNVSLNSLSQKASS---GSKIYPFKNSFPLPFSRSILPIRSLAFLKLCVRHNSTVPSK 119

  Fly    58 EEDGSQYHEDV-------------KQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIF 109
            :|..    :|:             |:|:.|:||..|..:....::.|.|..|::|:|.....::
pombe   120 DEQA----QDISKINTNGTLQTPNKKVNVFRLFTLARGQGWNFFIAGSLLLVSSGVTMSIPYIV- 179

  Fly   110 GNLANDMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIML-----VCSYLSITCFN 169
                      |.:|::|.|  .|.:::.::......|     |||::.|     .|::..|....
pombe   180 ----------GKILDAGSS--GDSSVTHIMGIPSGTF-----YIGLLGLFFLGSACNFGRIITLR 227

  Fly   170 YAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLS--------KMEDGLAEKVVMFV 226
            ..:...:..:|::.|...:..|..::||::.|::.||:..|.|        .:.|||...|
pombe   228 LLSERIVSRLRARLFAKCMSLDGAFFDFHKHGDLISRLTTDSSIVGKSLSMYLSDGLRSSV---- 288

  Fly   227 HYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMG--LVAVATSRLAKKEVTMYAGAAVVAEGA 289
               .|..|..::.:|   .:.|....||.:..||:|  .......:|::...........|:|..
pombe   289 ---SAIAGIGMMLYV---SMRLTGYMSLIVPPIALGAFFYGEYVRKLSRTTQDALGDLTRVSEEK 347

  Fly   290 LSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMF-SGIGFGLLWFFIYASYALAFWYGVGLV 353
            |:.:||.:||.||.:||..|.:.:....:| .||..| |||.||...|...|:.......|..:|
pombe   348 LANVRTTQAFLGERQEVNRYNDYIRNLFVL-AKREAFASGIFFGSTGFLGNATVIAILALGGRMV 411

  Fly   354 IKGYHEPAYENYDAGTMIT-VFFSVMMGSMNIGMAAPYIEAFGIAK--GACAKVFHIIEQIPEIN 415
            ..|       :...|.:.: :.::|..|...:|::..:.:   |.|  ||.:::|.:::..|:|.
pombe   412 AAG-------DITVGQLSSFLLYTVYAGGSIVGLSGCFTD---IMKGLGAASRLFELLDAKPKIA 466

  Fly   416 PIDGEGKKLNEPLTT----IEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCI 476
            |..|    :..|:|.    :.|:.|.|.|||||..||.:.|:..||.|..||:|.|||.||||..
pombe   467 PTVG----IPVPVTVGKAILSFRNVGFAYPTRPSASIFDNLSFDIHPGTNVAIVAPSGGGKSTIS 527

  Fly   477 QLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEA 541
            ||:.|||.|.:|.:|.:|.::...:::..||..|:|||||:||:.:|.|||.||:.:|::||||.
pombe   528 QLLLRFYAPSSGKILADGVDISTYNVHQWRSHFGLVGQEPVLFSGTIGENIAYGKSNASQEEIED 592

  Fly   542 AAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEA 606
            ||..||.: |:...|:.:.|.||.||.||||||||||||||||:|:|..|:|||||||||..:|.
pombe   593 AAKRANCS-FVLSFPEKWSTQVGTRGLQLSGGQKQRIAIARALLRNPAFLILDEATSALDGEAEV 656

  Fly   607 KVQAALEKVSAGR--TTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQL 669
            .|...::.:...|  |||.:||:|:|:||||:|:|:..|:|:|.|:.:.|.....:::.|:..||
pombe   657 MVDKTIQSLMHNRSMTTITIAHKLATIRRADQIIVVGDGKVLEQGSFERLSRPGTNFYKLMRWQL 721

  Fly   670 GE 671
            |:
pombe   722 GK 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	206/628 (33%)
mdl1	NP_595751.1	MdlB	146..723	CDD:440747	202/620 (33%)