Protein Alignment Mdr50 and mam1

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001018819.2
• Gene: mam1 / 2540405
• PomBaseID: SPBC25B2.02C
• Length: 1336
• Species: Schizosaccharomyces pombe
• Alignment Length: 1401
• Identity: 362/1401 - (25%)
• Similarity: 619/1401 - (44%)
• Gaps: 203/1401 - (14%)

  Fly    28 KLEDSDRDRKSFEPNKSK-KKSKHD-----------------------ESDASDE--------ED 60
            :.|.:..|..|:.|.||. ::.||:                       .||..|.        :|
pombe    11 QFEHASIDPPSYSPQKSSFEEKKHNFSITNKSLETLRSQESPCSTTFPVSDRKDALLNIPTVVDD 75

  Fly    61 GSQYHEDVKQVS----YFQLFRYATKKDRAL----YVIGLLSAVATGLTTPANSLIFGNL---AN 114
            ..|:.|::..||    :|.||.::   |..|    .:...|||....|.|.....:|..|   |.
pombe    76 EFQHTEELAGVSSWSDFFYLFHFS---DIPLIFGTLIFTCLSAALEPLMTWTTGKVFDALSQYAT 137

  Fly   115 DMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCS--------YLSI------ 165
            ..|.||.:            ||.:..:     ||..|..|:...|.|        |||.
pombe   138 SQITLGKM------------ISLINFN-----SLLITIFGLASCVFSFGVRFLWQYLSAIAGKRA 185

  Fly   166 --TCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHY 228
              .||:      :|:.:|..|.|:..        ::||.|.| ::..:...|..::..:......
pombe   186 RSLCFH------VLSSKSSTFYSLTE--------SKSGLVNS-VDRCIQFYEKSISLPMFHIAEN 235

  Fly   229 LVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGI 293
            |...:..|:::|...|.|:||.|.|.|:..:.:|.:....|...:|:......||.:.|.::|.|
pombe   236 LAISLSCLIISFRYSWSLTLVVLASYPIIILVVGFINSFLSSAYEKDRKSSEKAASILEKSISAI 300

  Fly   294 RTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYH 358
            :||.....:..|...:.:....:....::.:.......|:..||:|:.:....|:       |.|
pombe   301 QTVIFHSMQDTEYRYFADACSTSSKSFLRFSFLDAFQGGVSQFFLYSVFFQGLWF-------GNH 358

  Fly   359 EPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEI-NPIDGEGK 422
            ....:..:.|.::|||.|.:..:.::....|.|.  .:.||..:.  |.|:.:.|. :||:. .|
pombe   359 LATTKRVNVGQVVTVFGSCLSVASSLQQILPAIP--DLIKGKFSS--HFIKTLCESHDPIEA-AK 418

  Fly   423 KLNEPLTTIEFK------EVEFQYPTRPE--VSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLV 479
            :....:.:|.|:      .|.|.||:|.|  .|::| :::.|..|:.|.::||||.||||.|.|:
pombe   419 RSAAKIKSISFERGFRFDNVSFAYPSRDENLFSLIN-VSVFIPFGELVHIIGPSGSGKSTFISLL 482

  Fly   480 QRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAA 544
            .|::.|..||:..:...|:::|.:.|.|.|.:|.|:|::|..:|.|||....|:|:..:.|....
pombe   483 LRYFSPTYGNIYLDDFPLEEIDEHVLGSTITLVCQQPVIFDMTIRENIIMRNENASESDFEEVCR 547

  Fly   545 AANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQ 609
            .|....|.....:.|||...|  |.|||||:||||:||||:||.|||:|||.|||||..::..|.
pombe   548 LALVDEFALTFDQSYDTPCKE--ASLSGGQQQRIALARALLRDTEILILDEPTSALDPITKNLVM 610

  Fly   610 AALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDG 674
            .|:.....|:||:::.|.:|.:...:.::||:||.:::....:||:..:|...|:      ..|.
pombe   611 DAIRAHRKGKTTLVITHDMSQINNDELVLVIDKGHLIQRCARKELVLFEDFENNV------SIDE 669

  Fly   675 SVLSPTGDIYKNFDIKDED----------EEEIKVLSE------------DEDEDVMVTDEKNKK 717
            .||....|  ..|.:.:|:          .|....||.            |.:...:|:..|..:
pombe   670 KVLKEEAD--NPFILPNEESLLEKYWINYNESFSQLSRESLFTSLESPFTDIESPTIVSRRKIVE 732

  Fly   718 KKKKKVK----------------DPNEVKPML-----EVMKMNKPEWLQIAVGCISSVIMGCAMP 761
            ::|.:::                |..|....|     .:.|:.|..|. ..:|.::|:|.|.::|
pombe   733 QRKLRMEKESFQETNVDQTFHLFDDKEHACSLTLIFKSIWKVKKLRWF-FLLGLLTSLIQGASVP 796

  Fly   762 IFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGL 826
            |||.:....|.:....|....|.    .:|...|:.....|.:.|...|.|.|:.:...:..|.|
pombe   797 IFAYVISKCLNLFMQIDPSIGVA----FWSSMVLVVAAGSGASYFFSHYIFSISAKIWCDHYRLL 857

  Fly   827 MFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWS 891
            ..:.:..|:.||||...|....|...|..:.:.::......|..:..:.:...:|||.|....|.
pombe   858 AVKVLFTQDQAWFDQIENYPLVLSKILVNNISDMRNMISSLIEEVFIAFTMAIIGIAWSFATGWR 922

  Fly   892 LGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYI 956
            |..|.:|.:|.:.:...|...:...........:.:.|.:..:.:.|:.|:........|.:|:.
pombe   923 LAAVLVAVSPILCLTSRMFSYIYVSTERMCQDVVISTTSILHKTIVNLDTIKGYSVLSFFRENHK 987

  Fly   957 GMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTA 1021
            ..|..:.|..||...:..|.:.:..||::|..|...|..:..:...   |..|.::.|.|.:.|.
pombe   988 NSLRKSWEAFKRRAFWTSLGFAINNSLLYFVRALLFYCSSIFISKE---FYTVEQMVQVLSLATF 1049

  Fly  1022 SI---ANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYP--T 1081
            ::   :..:...||:.....|...:......:|..:.:.|..:.|  ..|.:.||.|.|:||  .
pombe  1050 TLLMASTCIMSLPNVSASRIATSRVLKLSSLKPGNLHKSGYLKFP--LVGKIEFDGVSFAYPDSE 1112

  Fly  1082 RSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRN 1146
            |:.: .|..:.|::...:|:|:||.||.||||.::|:::.|..::  ..||...:.|:....|..
pombe  1113 RNHL-ALNNVSLSIEAREKVAIVGISGSGKSTLVELLRKTYPSED--IYIDGYPLTNIDTNWLLK 1174

  Fly  1147 QLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQL 1211
            ::.||.|:|.|...||.|::.||.: |::  ..::.|..|:.:.|.|.|||.|.||.:.|.....
pombe  1175 KVAIVDQKPHLLGSTILESLLYGVD-RDI--NSVMDALDKTYMTEVIQNLPNGLDTPLLEFSKNF 1236

  Fly  1212 SGGQKQRIAIARALIRNPKIMLLDEATSALDAES----EKVVQDALDAASEGRTTISIAHRLSTV 1272
            ||||.||:|.||||:|||::::|||.|||||::|    ||.:|:.      ..|.:.|.|:.|.:
pombe  1237 SGGQIQRLAFARALLRNPRLLILDECTSALDSKSSLLLEKTIQNL------SCTVLIITHQPSLM 1295

  Fly  1273 VHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKL 1308
            ..:|.|.|.::|:|.|:|...:|: ||..::  :||
pombe  1296 KLADRIIVMDSGIVKESGSFDELM-NRHTHF--WKL 1328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	346/1326 (26%)
mam1	NP_001018819.2	MdlB	103..649	CDD:440747	164/592 (28%)
		MdlB	768..1328	CDD:440747	156/584 (27%)