Protein Alignment Mdr50 and Tap2

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_035660.3
• Gene: Tap2 / 21355
• MGIID: 98484
• Length: 702
• Species: Mus musculus
• Alignment Length: 538
• Identity: 177/538 - (32%)
• Similarity: 276/538 - (51%)
• Gaps: 41/538 - (7%)

  Fly   150 NTYIGIIMLVC-----SYLSITC----FNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVAS 205
            :.:...|..:|     |..|..|    |.:......|.||.:.|.|:|.||:.::...::||:.|
Mouse   186 DAFASAIFFMCLFSVGSSFSAGCRGGSFLFTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNS 250

  Fly   206 RMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSR 270
            |::.|.|.|...|.....:.:..||..||..........:|:.:.|..||||..|..:.......
Mouse   251 RLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQA 315

  Fly   271 LAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLW 335
            :.|:.....|.|..|...|:.|::||::|..|.:||:.|||.:...:.|..:|::...:...:..
Mouse   316 VLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVSHYKEALERCRQLWWRRDLEKDVYLVIRR 380

  Fly   336 FFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGA 400
            ........|....||..::.|      |....|.:..:.:...:|.....:...|.:..... ||
Mouse   381 VMALGMQVLILNCGVQQILAG------EVTRGGLLSFLLYQEEVGQYVRNLVYMYGDMLSNV-GA 438

  Fly   401 CAKVFHIIEQIPEINPIDG-------EGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHR 458
            ..|||..:::.|.: |..|       ||:        :||::|.|.||.|||..:|..|...:|.
Mouse   439 AEKVFSYLDRKPNL-PQPGILAPPWLEGR--------VEFQDVSFSYPRRPEKPVLQGLTFTLHP 494

  Fly   459 GQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSI 523
            |...|||||:|.||||...|:|..|.|..|.||.:|..|.:.|.::|..::.:|||||:||:.|:
Mouse   495 GTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSV 559

  Fly   524 YENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDP 588
            .:||.||..|....::.|||.||.|..||.::..|.:|.:||:|.||:.|||||:||||||:|:|
Mouse   560 KDNIAYGLRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNP 624

  Fly   589 EILLLDEATSALDTASEAKVQAALE--KVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTH 651
            .:|:|||||||||    |:.:.||:  :....||.:::||||.||:.||:::|:.:|.:||   |
Mouse   625 RVLILDEATSALD----AQCEQALQNWRSQGDRTMLVIAHRLHTVQNADQVLVLKQGRLVE---H 682

  Fly   652 QELMELKDHYFNLVTTQL 669
            .:|.:.:|.|.:||..:|
Mouse   683 DQLRDGQDVYAHLVQQRL 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	177/538 (33%)
Tap2	NP_035660.3	3a01208	1..696	CDD:273363	174/532 (33%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	300..388		21/87 (24%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	413..432		2/18 (11%)