Protein Alignment Mdr50 and haf-8

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_502776.1
• Gene: haf-8 / 190369
• WormBaseID: WBGene00001818
• Length: 633
• Species: Caenorhabditis elegans
• Alignment Length: 609
• Identity: 219/609 - (35%)
• Similarity: 326/609 - (53%)
• Gaps: 78/609 - (12%)

  Fly   126 GKSYR-------------ADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSI----------TC 167
            ||.:|             |.:.|...|..::...::|.....||...|..|::          .|
 Worm    51 GKQWRWFVPAYTLLILDCALNLIEPALYGQMMTNAIQMKSFDIIKRACLLLALIQFSEATCKSAC 115

  Fly   168 FNYAAHSQILT---IRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYL 229
            :.:..:::.||   ||.:.|||||||::.::|.|::|::.||:..|...:.:.|...:...|:.|
 Worm   116 YFFMQYAEKLTARNIRIQLFRSILHQEISFFDENKTGQLVSRITHDSESISNTLPVHIETLVNNL 180

  Fly   230 VAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIR 294
            ..|.||:.:.|...|||:|......|:|.:......:|..:|::||....|.:....|..||.||
 Worm   181 FMFFGSIPIMFCYSWQLTLTSFIEFPITLLMTRYYGLAVEKLSEKENDATAASNETVEEVLSAIR 245

  Fly   295 TVKAFEGEAKEVAAYKERV-----VAAKILNIKRNMFSGIGFGLLWFFIYASY-ALAFWYGVGLV 353
            ||::|..|..|...|.:..     ::.|.:.:      |..:...|..:..|. .:.:.||..|.
 Worm   246 TVRSFAAENFEQKRYTKNTEDWFKISTKTVTL------GTIYNYFWALMLRSQDVIRYLYGGYLA 304

  Fly   354 IKGYHEP------AYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIP 412
            :.|...|      .:.::...|.|..|.|:..|.|         :..|:::    ||.|:|.:.|
 Worm   305 LNGRMAPEALLTFIFYHWRLHTAINAFSSLFSGVM---------KTIGLSR----KVIHLINRKP 356

  Fly   413 EINPIDG------EGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCG 471
            :::...|      :||        |||:.|||.||||..|:::|.:||.|..|:|||||||||.|
 Worm   357 QLDYDFGTETPEIQGK--------IEFEVVEFAYPTRKTVNVINGINLSIESGKTVALVGPSGNG 413

  Fly   472 KSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATR 536
            |||.:.|:|:||.||:|.:|.:|..:::::.....|.|.:|.|||.||:.:|.|||.:|.|:.|.
 Worm   414 KSTLVSLIQQFYTPQSGRILTDGIPIQNINHQHYHSNIALVAQEPTLFSGTIRENILFGIENGTE 478

  Fly   537 EEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALD 601
            |.:..||..||...|:.|:..||||..||:|.|:||||||||||||||||:|.:|:|||||||||
 Worm   479 EAMLKAAEMANVHEFVSKMDDGYDTKCGEKGVQMSGGQKQRIAIARALIRNPRVLILDEATSALD 543

  Fly   602 TASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDH-YFNLV 665
            :.||..||.||.|.:..||.|::||||||||:|.:|.||..|.|.|.|.|.||||.:|. |:.||
 Worm   544 SESEGMVQEALNKCAKERTVIVIAHRLSTVRKAQKIAVIENGSVKEMGCHDELMENQDGLYYKLV 608

  Fly   666 TTQLGEDDGSVLSPTGDIYKNFDI 689
            :.||    ||::..  :|:..||:
 Worm   609 SKQL----GSIVDT--NIFNCFDM 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	219/609 (36%)
haf-8	NP_502776.1	3a01208	20..608	CDD:273363	210/583 (36%)