Protein Alignment Mdr50 and pgp-10

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_509205.2
• Gene: pgp-10 / 180981
• WormBaseID: WBGene00004004
• Length: 1382
• Species: Caenorhabditis elegans
• Alignment Length: 1445
• Identity: 412/1445 - (28%)
• Similarity: 677/1445 - (46%)
• Gaps: 222/1445 - (15%)

  Fly    15 SRSQYKTNIVLGA--KLEDSDRDRKS-------FEPN-------KSKKKSKHDESD-----ASDE 58
            :.|..|||.:..|  |.|....|:||       .||:       |:.||:.....|     :||.
 Worm     8 NESTNKTNEIGNAEKKEEAETEDKKSLKSMIYPIEPSTLYIDDLKNSKKAYDVTMDDPLDKSSDS 72

  Fly    59 EDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLL 123
            :....:.|     .|.:|:.:|...|..|..:||.||:......|...||.||    .:.:..|.
 Worm    73 KPKLGFFE-----PYKRLYAFADSIDMQLMAMGLFSALLQSALPPFVWLIMGN----FVSISILR 128

  Fly   124 ESGK--------SYRADDAISTLLLDKVRQFSLQNT-------YIGIIMLVCSYLSITCFNYAAH 173
            |.||        .|..||           ||:...|       .:.|.|.:.::.....:..::.
 Worm   129 EEGKLGLKNLTSDYPIDD-----------QFAHSATPAFISMLGLSIAMFIAAFCQRIAWEISSI 182

  Fly   174 SQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAE---KVVMFVHYLVAFVGS 235
            .|:..|:..:.|.:|..|:.|.:..|||.||:.:.|....:.:|:::   .||..:.||:..:|
 Worm   183 RQVFRIKKAYIRKLLLMDISWLESRQSGHVAAMLQESADSIYNGISDHLPMVVFILSYLLVNIG- 246

  Fly   236 LVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFE 300
             |..::: |.::|....::||..|:..|.:...:...::|..:......:.....:.|.||.:|.
 Worm   247 -VCLYIQ-WDVTLFMCLAIPLLIISRILYSKWFANTMEEETKLQNKITNLVNETFNCITTVISFA 309

  Fly   301 GEAKEVAAYKERVVAAKILNIKRNMFSGIGFG-----LLWFFIYASYALAFWYGVGLVIKGYHEP 360
            .:.:::..: |::.|......:..:.|.:.|.     ||...|:..   |..||:..|
 Worm   310 AQKQKINKF-EKLSAEHSKLTEERLRSSVVFDSLTQILLTELIFTG---ALCYGIWRV------- 363

  Fly   361 AYENYDAGTMITVFFSVM---MGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEI-------- 414
              .:...|.:..:..:::   :.|::||.   ::.....||....::..::.:.|:|
 Worm   364 --ADNSPGRLCALAINMLYMCVTSISIGF---HMNGATRAKDNAKEICEVLNEQPKIEVELASID 423

  Fly   415 NPID-----------------GEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTV 462
            |.||                 |:|        .:.|:::.|.||:|.|..:|..::.|:..|:.:
 Worm   424 NNIDYVPVTRCKYRRQSMKFMGKG--------ALHFRDIHFSYPSRKETEVLRGISFKVEAGEKI 480

  Fly   463 ALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENI 527
            |:||.||.||||...|:.|||||..|.:|.:|.|:|.:..:.||.:..:|.|||:||..:|.:||
 Worm   481 AIVGSSGSGKSTLTALLLRFYDPTKGAILLDGENIKTMCPDDLRGQCSLVSQEPVLFDGTISDNI 545

  Fly   528 RYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILL 592
            ||||.|||::||..||....|..||..||.|..|.|||||.|||||||||:|||||:||.|.:|:
 Worm   546 RYGRLDATQQEINDAARKVGAWKFINSLPDGMQTRVGERGHQLSGGQKQRVAIARAVIRKPIVLI 610

  Fly   593 LDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELME- 656
            .||||||||...|.:|.||::..|.|.|||.:||||||::.:|||:|:::|::||.|...||:.
 Worm   611 FDEATSALDNIHEEEVNAAIDLASEGLTTITIAHRLSTIKNSDRIIVLHEGKIVEEGVPDELIAD 675

  Fly   657 --------LKDHYFNLVTTQ-------------------------LGEDD------GSVLSPTGD 682
                    ..|...:.:|.|                         :..|.      .|.|.....
 Worm   676 ANGIFHKMYNDQRLDQLTQQHQQLHQQQAKPPSLQQQMSFSPPPNMDPDQQRRAWARSSLGGNKK 740

  Fly   683 IYKNFDIKDEDEEEIK--VLSEDEDEDVMVTDEKNKKKKKKKVKDPNE----------------- 728
            :.|::.:...::|::|  |:|:.:.|.:   |.|..|.....||...:
 Worm   741 LGKSYSVNSMEKEKLKLPVMSKKKSERL---DYKYSKVHSMDVKQHTDSMHDDDDLPGKETNFTV 802

  Fly   729 VKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLF----GSILQILSVKDNDQYVRENSNQ 789
            :|.::...:...|    :..|.|.:.|:   ..:|.:|.    .|:|:|....|.::.::
 Worm   803 LKDLIYSYRTGLP----LLAGAIPTTIV---RAVFYLLICFQVASVLEISIAPDEERALQ----- 855

  Fly   790 YSLYFLIAGIVVGIATFLQIY------FFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGS 848
               .|::|.|...:.....|:      |..:.|....:.:|..||..:||...|:||::.|..|.
 Worm   856 ---IFIVAAIYTALIIVKTIFEALGRIFIALYGHGFCKFMRNEMFRKVLRHGAAYFDEERNSPGR 917

  Fly   849 LCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTL 913
            |..::..:::.:.....|::..::..:......|..:::..|.:.|:.    .|...|:::.|.|
 Worm   918 LVHKVINESSTLNEIMEQKLDMLIPGVVCSLFSIVCALWINWKMALLC----SFQFPAYFVIRIL 978

  Fly   914 MAKENMGSAKTM----ENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRG 974
            ..:|.....:.|    :....||..|::|:.|:.:...:..|:..:...|.|..:..::.:....
 Worm   979 QIREGTKRQRQMVDEEKKAANLASVVLANMSTIKAYNLQSHFYNVFCDALKPVSQCMQKQSLISA 1043

  Fly   975 LVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSA 1039
            ||:....|..:...|..:::|...::...|...|..:|......|....:..:|...:..|...|
 Worm  1044 LVFACQYSFTYILIAITLHFGKVMMLANEISVFDYMRVVLLTQFGANFFSQLIASVSDFTKAQIA 1108

  Fly  1040 AKTIFTFLRRQPSIVDRPGVSRDPWHS--EGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIA 1102
            |:.:...:|..|  ||...:|.:....  ||.:....|.|.||:|..:.||..|.|.|..|:.||
 Worm  1109 AENVMRVIREPP--VDMDNLSEEGLRPKLEGNLCLKDVSFRYPSRPIVPVLTNLNLKVRGGESIA 1171

  Fly  1103 LVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENIS 1167
            ||||||.|||:.|.|.||.|:..:|..:||:.::::::...||..:..|.|||.||..||:|||:
 Worm  1172 LVGPSGSGKSSVISLFQRMYNATDGVVIIDKYNIKSINPAYLRRCIVQVGQEPDLFSFTIKENIA 1236

  Fly  1168 YGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIM 1232
            :|......|..::|.|.|.::||.||.:||.||||.:||.|||||||||||||||||:||.|.::
 Worm  1237 FGMMESEATIDKVIEAAKIADIHNFITSLPQGYDTEVGEFGAQLSGGQKQRIAIARAIIRKPTVL 1301

  Fly  1233 LLDEATSALDAESEKVVQDALDAASEGR----TTISIAHRLSTVVHSDVIFVFENGLVCEAGDHK 1293
            ||||||||||:.||:.||:|.:......    |.|.|||||||:.:.|.|:|..:|.:.|.|.|:
 Worm  1302 LLDEATSALDSASEREVQNAFERVKRSTKTQCTCIQIAHRLSTIRNVDKIYVIVHGEIAEEGSHE 1366

  Fly  1294 QLLANRGLYYTLYKL 1308
            ||:..:|:||.:.::
 Worm  1367 QLINLKGIYYEMNQM 1381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	393/1368 (29%)
pgp-10	NP_509205.2	MdlB	76..687	CDD:440747	195/657 (30%)
		MdlB	796..1378	CDD:440747	182/602 (30%)