Protein Alignment Mdr50 and pgp-9

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_507487.1
• Gene: pgp-9 / 180165
• WormBaseID: WBGene00004003
• Length: 1294
• Species: Caenorhabditis elegans
• Alignment Length: 1299
• Identity: 532/1299 - (40%)
• Similarity: 764/1299 - (58%)
• Gaps: 67/1299 - (5%)

  Fly    46 KKSKHDESDASDEEDGSQYHEDV---KQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSL 107
            ||.|.|    |..|..|:..|:.   .::|.|||:||.:..||.:..:|::.:.|||:..|..|:
 Worm     5 KKKKDD----SSSEGSSEKKEEAPPPPKISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSI 65

  Fly   108 IFGNLANDMIDLGGLLESGKSYRADDAISTL-LLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYA 171
            |.||::.:.:.||.:.....|..::.|.:.. ...:|.|..|:..|:|..:....:|..:||...
 Worm    66 IMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVI 130

  Fly   172 AHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSL 236
            ........|.:||.|::.|::.|||.|.||.:::::.::|.::.:|..:||.:....:..|:|..
 Worm   131 CEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGF 195

  Fly   237 VLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEG 301
            .:||...|.|:|:.::..|...|....:|...:..|.||...||.|..:||..|:.||||.||.|
 Worm   196 AVAFTYDWLLTLIMMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNG 260

  Fly   302 EAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYD 366
            :..|...|::.:...|...||::...|.|....:..|||||.||||.|...|..|       ..:
 Worm   261 QEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG-------RLE 318

  Fly   367 AGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTI 431
            :||::|||||||||||.:|.|.......|.|.||.|.::.:|::||||:....||:..::....|
 Worm   319 SGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRI 383

  Fly   432 EFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTN 496
            ...:|||.||||.:|.||..::|....||||||||.|||||||.|||:||||:|.||.:|.:...
 Worm   384 SVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 448

  Fly   497 LKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDT 561
            ::|.:|.:||..:|||.|||.||.|||.:||||||.|.:.|:|..|...||||.|||..|:|.:|
 Worm   449 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNT 513

  Fly   562 LVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAH 626
            |||:||.|:||||||||||||||:|:|:||||||||||||..||:.||:|||..|.|||||::||
 Worm   514 LVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAH 578

  Fly   627 RLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKD 691
            ||||||.||:|:|:..|:|:|.|||:.|:|.|..|..||..|              ::.:.|.|.
 Worm   579 RLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ--------------VFADVDDKP 629

  Fly   692 EDEEEIKVLSED----------EDEDVMVTD-----------EKNKKKKKKKVKDPNEVKP-MLE 734
            :.:|..:.:|..          :.::..|.:           ||..|:.||::::...||. :.:
 Worm   630 KKKEAERRMSRQTSQRKGSVNFKTQESQVDEKPGAPPAPEAAEKEIKRLKKELEEEGAVKANLFK 694

  Fly   735 VMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGI 799
            :::..:|||:.|....|:::|.|..||.|::.|..|:.:.|..|.|| ::::.:.::|.||:...
 Worm   695 ILRYARPEWIYIFFAIIAALIQGAVMPAFSLFFSQIINVFSNPDRDQ-MKKDGHFWALMFLVLAA 758

  Fly   800 VVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGAT 864
            |.|.:...|...||:|.||||.|:|..::..:|||:..:||...:..|.:..||:.||..::.|.
 Worm   759 VQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAI 823

  Fly   865 GQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGS----AKTM 925
            ..|:|:|..:|:::..|:.::.||.|.:..:.:|..||:.:.    :.||.|.:.||    ||.|
 Worm   824 DYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG----QALMMKYHGGSATSDAKEM 884

  Fly   926 ENCTKLAVEVVSNIRTVASLGREEMFHQNYIGML-IP-AVEISKRNTHFRGLVYGLARSLMFFAY 988
            ||..|.|:|.:.|||||.:|..:...:..:...| .| ...|||  ...|||.||.|.|:.||.|
 Worm   885 ENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK--AIIRGLTYGFANSIQFFTY 947

  Fly   989 AACMYYGTWCVIHRGILF--GDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQP 1051
            ||...:|.:.:..:.:|.  .:|.:|..|:.....:|..|.::.|...|...||..||..|..:|
 Worm   948 AAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEP 1012

  Fly  1052 SIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQ 1116
            .|.........|..| |.|:.:||.|.||.|..:.:|:||.:.|..||.:||||||||||||.|.
 Worm  1013 RIDGMTSSGTYPQLS-GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVIS 1076

  Fly  1117 LIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEII 1181
            |::|.||..|||..:|..|:|.::..:||..:.:|||||||||.:|||||.||......|.::|.
 Worm  1077 LLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIE 1141

  Fly  1182 SACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESE 1246
            :||.|:|||:||..||.||:||:||||.||||||||||||||||||||||:||||||||||.|||
 Worm  1142 TACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 1206

  Fly  1247 KVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQS 1310
            |.||.|||||::.||.|.:||||||:|::..|.|.:||.|.|.|.|.:|:|.||.|:.|.:.||
 Worm  1207 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	522/1269 (41%)
pgp-9	NP_507487.1	MdlB	30..620	CDD:440747	260/596 (44%)
		MdlB	689..1273	CDD:440747	252/590 (43%)