Protein Alignment Mdr50 and pgp-1

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_502413.1
• Gene: pgp-1 / 178215
• WormBaseID: WBGene00003995
• Length: 1321
• Species: Caenorhabditis elegans
• Alignment Length: 1313
• Identity: 507/1313 - (38%)
• Similarity: 753/1313 - (57%)
• Gaps: 72/1313 - (5%)

  Fly    43 KSKKKSKHDESDASDE----EDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTP 103
            |:.:..:.|..|::.|    .|..:  |.|.:||..||:||.|..::.|..||.|.||.||...|
 Worm    30 KTVEDYEGDNIDSNGEIKITRDAKE--EVVNKVSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLP 92

  Fly   104 ANSLIFGNLA----NDMIDLGG----LLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVC 160
            ..|::.|.::    |:.|.:..    .|.:|::|...| ....:::.|..::...  :|  |...
 Worm    93 LMSILQGKVSQAFINEQIVINNNGSTFLPTGQNYTKTD-FEHDVMNVVWSYAAMT--VG--MWAA 152

  Fly   161 SYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMF 225
            ..:::||:.|.|......:|.:|.:|||.|::.|:|.|.||.:|:::.::|.::::|..:|:.|.
 Worm   153 GQITVTCYLYVAEQMNNRLRREFVKSILRQEISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMA 217

  Fly   226 VHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGAL 290
            ..||..|:...::||...|||:||.|...|:..:....:|.:.|..|.:|...||.|..|.|..:
 Worm   218 FQYLSQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETI 282

  Fly   291 SGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIK 355
            |.||||.:..|...|:..|...|..||...:.:.:|.||.||.:....:.|:||||:.|||.|..
 Worm   283 SSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHD 347

  Fly   356 GYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGE 420
            |       :.:.|.|:|.|.|||||||.:|:|.|.:...|.|:||.:.::.::::.|.|:.....
 Worm   348 G-------SLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKA 405

  Fly   421 GKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDP 485
            |:|..:....|..:.|.|.||:||:|.||..:||:::.||||||||.|||||||.|.|:.|:||.
 Worm   406 GRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDV 470

  Fly   486 QAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAI 550
            ..|.:..:|.:::|:::.:||..:.||.|||.||..:|.|||..|:|..||||:.||...|||..
 Worm   471 LKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEK 535

  Fly   551 FIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKV 615
            |||.||.||:||||:||.||||||||||||||||:|:|:||||||||||||..||..||.||:|.
 Worm   536 FIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKA 600

  Fly   616 SAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPT 680
            :.||||||:||||||:|.||.|:....|:|||.|.|:.||..:..|::|||.|...|.....:..
 Worm   601 AKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDAVDSAAEG 665

  Fly   681 GDIYKNFDIKDEDEEEIKVLSEDEDEDVM---------------VTDEKNKK-------KKKKKV 723
            ....:|...:...|.|.......|.:|:|               |.|||.::       :.|:::
 Worm   666 KFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIGKDALSRLKQEL 730

  Fly   724 KDPNEVKP-MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENS 787
            ::.|..|. :.|::...:|..|.:.:|..::.|.|...|.::|.|.|.:.:.:  .|........
 Worm   731 EENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVFA--GNPADFLSQG 793

  Fly   788 NQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCAR 852
            :.::|.||:.....||.:||..:|.|||.|.||..||..:|..:|.|.:.:||...|.:|.:..|
 Worm   794 HFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTR 858

  Fly   853 LSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKE 917
            |:.|...::.|...|..|::.::.::..||.|:.:|.|.:.|:.:|..|.:....|::......:
 Worm   859 LATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAFGQYLRGRRFTGK 923

  Fly   918 NMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGML-IPAVEISKRNTHFRGLVYGLAR 981
            |:.||....:..|:|:|.:.|:|||.:|.||:.|::|:...| ||..|..| ....:||.||.|.
 Worm   924 NVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEAIK-EAFIQGLSYGCAS 987

  Fly   982 SLMFFAYAACMYYGTWCVIHRG--ILFGD--------VFKVSQALIMGTASIANALAFAPNMQKG 1036
            |:        :|....|....|  ::..|        |.:|..|:.:.|:::..|.::.|...|.
 Worm   988 SV--------LYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKA 1044

  Fly  1037 VSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKI 1101
            ..|...||..||: .|.:|...::.:.....|.|.|..|:|:||.|.||::||||..:|..||.:
 Worm  1045 TFAGGIIFGMLRK-ISKIDSLSLAGEKKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTL 1108

  Fly  1102 ALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENI 1166
            ||||||||||||.:.|::||||...|...||..:::.::..:.|:|:.||||||.|||.:|.|||
 Worm  1109 ALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENI 1173

  Fly  1167 SYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKI 1231
            .||.:..:||..::..|.:.:|||.|||.||.|::||:|::|.||||||||||||||||:|||||
 Worm  1174 IYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKI 1238

  Fly  1232 MLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLL 1296
            :||||||||||.|||||||:|||.|.||||.|.|||||:||:::|.|.|..||.:.|.|.|.||:
 Worm  1239 LLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLM 1303

  Fly  1297 ANRGLYYTLYKLQ 1309
            :.:|.||.|.:.|
 Worm  1304 SEKGAYYKLTQKQ 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	499/1280 (39%)
pgp-1	NP_502413.1	MdlB	131..653	CDD:440747	229/532 (43%)
		MdlB	733..1319	CDD:440747	234/596 (39%)