Protein Alignment Mdr50 and hmt-1

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001022812.1
• Gene: hmt-1 / 176540
• WormBaseID: WBGene00001815
• Length: 801
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 175/589 - (29%)
• Similarity: 290/589 - (49%)
• Gaps: 75/589 - (12%)

  Fly   762 IFAVLFGSI----LQILSVKDNDQYVRENSNQYSLYFLIA--------GIVVGIATFLQIYFFGI 814
            :|.::.|.:    |.|||....|:....::.||||.||..        |.:.|....::.|.:..
 Worm   231 LFLLIIGRLINVSLPILSKWIVDELATPDTFQYSLLFLATFLKFLQGNGAMGGFLNTVRTYLWIP 295

  Fly   815 AGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLA 879
            ..:..|..|...:|:.:....:.|  ..:..||.:...:....::|.......:..:|.:|:.:.
 Worm   296 IQQYTTRELEVELFKHLHSLSLRW--HLSRKTGQVLRVMDRGTSSVNNILNYILFNVVPTIADIV 358

  Fly   880 LGI-----ALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKE----NMGSAKTMENCTK-LAVE 934
            :.:     |.:.|:    ||:.     |..:|.|:..|:...|    .:..|...:|.|. :|.:
 Worm   359 IAVIFFFSAFNAYF----GLIV-----FGTMALYLTVTISITEWRTQYIREANEKDNATSAIATD 414

  Fly   935 VVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCV 999
            .:.|..||...|.|| |..|.....|.:.::::..|.         .||   |:..|:..   .:
 Worm   415 SLINYETVKYYGNEE-FEVNRFKNAIESYQVTEWKTQ---------ASL---AFLNCLQN---AI 463

  Fly  1000 IHRGILFGDVFKVSQALIMGTASIANALAFAPNM-----------------QKGVSAAKTIFTFL 1047
            |..|::.|.||.|...:...|.::.:.:.|...:                 ||.....:.:|..:
 Worm   464 IGIGMIGGSVFVVYMIVHEKTLTVGDYVLFTTYLLQLYTPLNFFGTIYRVIQKAFVDMENMFDLM 528

  Fly  1048 RRQPSIVDRPGV--SRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCG 1110
            ..:..:.|.|..  ..||   .|.:....:.|.|.|  .:.|:|.:...:..||.:||||.||.|
 Worm   529 NDEVEVKDLPHALPYTDP---RGTISVKNLTFEYNT--GLPVIKNISFEIGNGQTVALVGSSGSG 588

  Fly  1111 KSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNV 1175
            |||.|:|:.|.::..||:...|..||||.:|.:||.|:|||.|:.:||:.||..||.:|  ..:.
 Worm   589 KSTLIRLLFRLFESTEGSIEFDGIDVRNYTMHSLRQQIGIVPQDTVLFNDTIMYNIRFG--RPDA 651

  Fly  1176 TDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSA 1240
            :|:|:|.|.|.:.|||.|.:||.||.|.:||:|.:||||:|||:||||.:::.|:.:.|||||||
 Worm   652 SDEEVIEAAKAAMIHEKITSLPEGYATMVGERGLKLSGGEKQRVAIARTILKKPQFIFLDEATSA 716

  Fly  1241 LDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTL 1305
            ||..:|:.:|..|:...:.||.:.:||||||||::|:|.|.:.|::.|.|:||:|||.:|.|.::
 Worm   717 LDTPTERAIQKCLEKLCKSRTGVVVAHRLSTVVNADLILVLDKGIILERGNHKELLAQQGTYASM 781

  Fly  1306 YKLQ 1309
            ::.|
 Worm   782 WEAQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	174/586 (30%)
hmt-1	NP_001022812.1	ATM1	213..791	CDD:444078	175/589 (30%)