Protein Alignment Mdr50 and haf-2

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_495537.2
• Gene: haf-2 / 174204
• WormBaseID: WBGene00001812
• Length: 773
• Species: Caenorhabditis elegans
• Alignment Length: 566
• Identity: 205/566 - (36%)
• Similarity: 309/566 - (54%)
• Gaps: 58/566 - (10%)

  Fly   138 LLLDKVRQFSLQNTYIGIIMLVCSYLSIT----------CFNYAAHSQILTIRSKFFRSILHQDM 192
            ::.|.|.:..:|.....||:|.|  |:.|          ||:||.....|.||...|.|::.||:
 Worm   235 VISDIVNKRGIQALIHSIIVLTC--LTATSSLFGGLRGGCFDYATALVTLRIRLDLFTSLIRQDI 297

  Fly   193 KWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLT 257
            .:||..::|:..||:..|...:...::..|.:|:...|..:|:|....:..|:|::|       |
 Worm   298 AFYDTAKTGDTMSRLTSDCQTISSTVSTNVNVFMRNGVMLIGALAFMILMSWRLAMV-------T 355

  Fly   258 FIAMGLVAVAT-------SRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVA 315
            |||:.||...|       .::::|.....|....:||..:|.:|||::|..|.||:..:::|:.:
 Worm   356 FIAVPLVGFITKAYSSFYDKISEKLQQTIAETNQMAEEVVSTMRTVRSFACEKKELKRFEDRLSS 420

  Fly   316 AKILNIKRN---MFSGIGFGLLW---FFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVF 374
            ...:|.|::   :|      ..|   |...|......:||..||:.|..|..       .:||..
 Worm   421 TLSVNRKKSIAYLF------YTWNNEFCDNAILVAVLFYGGHLVMTGKMEKE-------QLITFL 472

  Fly   375 FSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLT--TIEFKEVE 437
            ...|....|:...:..:.....|.||..|||.::.:.|:.. :||    :..|..  .|.|..|.
 Worm   473 LYQMQLGENLYYLSYVMSGLMEAVGASRKVFDLMNRKPQFE-LDG----MQRPFVNGNITFSHVG 532

  Fly   438 FQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDI 502
            |.||:||...:|..|.|.|..|:|||||||||.|||:.:.|::.||:|..|::..:|..:||::.
 Worm   533 FTYPSRPNNPVLKDLTLSIKSGETVALVGPSGGGKSSIVSLIEHFYEPDEGSVTLDGVPIKDINH 597

  Fly   503 NWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERG 567
            .:...::.:|.|||:|:..|:..||.||.:.||.:::..|:..||...|:.:|.|||||..||:|
 Worm   598 VYYHQKVALVAQEPVLYNGSVRHNILYGCDFATEDDMLNASKMANVHDFVMELEKGYDTNCGEKG 662

  Fly   568 AQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVR 632
            .|:||||||||||||||:|:|.:|:||||||||||.|||.||.||.:.:..||.|||||||||:.
 Worm   663 VQMSGGQKQRIAIARALVRNPAVLILDEATSALDTESEALVQQALSRCAQERTVIIVAHRLSTIE 727

  Fly   633 RADRIVVINKGEVVESGTHQELMELKD-HYFNLVTTQL-----GED 672
            :|::|.||.||.:|:.|||.|||...| .|::||:.|:     |||
 Worm   728 KANKIAVIVKGCLVQMGTHTELMTDTDGMYYSLVSRQMLSAKVGED 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	205/566 (36%)
haf-2	NP_495537.2	3a01208	15..761	CDD:273363	199/552 (36%)