Protein Alignment Mdr50 and haf-6

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_490828.3
• Gene: haf-6 / 171694
• WormBaseID: WBGene00001816
• Length: 668
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 202/583 - (34%)
• Similarity: 313/583 - (53%)
• Gaps: 39/583 - (6%)

  Fly    86 ALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQN 150
            |..|..:|||. ..:..|   |..|:|.|.::.:  :.:...:.|:.       .::::..:|..
 Worm   100 AAVVCAILSAY-INIQIP---LCLGDLVNGIVKI--IKDESNNLRSH-------FEQLKPSALHL 151

  Fly   151 TYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKME 215
            ..:.:.....::|.||............:||..|:.:||.||.::|.::|||:::|:|.|:.:.:
 Worm   152 MTLYVAQSALTFLYITFLTVLGERMATKMRSDLFQKLLHHDMAFFDSHKSGELSARLNADVQEFK 216

  Fly   216 DGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYA 280
            ......|...:......:|.:...:.....:::..:..:|...:|...:.....:|:::.....|
 Worm   217 SSFKLCVSQGLRTFAQTIGCIGSLYFLSPTMTMYTVAVVPGIILAGSAIGAGLRQLSRRAQGQSA 281

  Fly   281 GAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLW----FFIYAS 341
            .|:.|::.||:.|||::||..|..|...:...:..|:.:..:    .|:|.||..    .|:...
 Worm   282 TASAVSDEALTNIRTIRAFAMEKLESRLFDNELDKARAMQEQ----LGVGIGLFQAGTNLFLNGM 342

  Fly   342 YALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIE-AFGIA-KG--ACA 402
            .....:.|..|:.||...|.           ...|.::.:..|..:...:. .||.| ||  |..
 Worm   343 ILSVLYGGSNLISKGEMTPG-----------ALMSFLVSAQTIQRSLSQLSIIFGTAIKGWTAGG 396

  Fly   403 KVFHIIEQIPEINPID-GEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVG 466
            :|.......|.| |:| |.....:.....|:|::|.|.|||||..::...|.|.|..||.|||.|
 Worm   397 RVLQFSRLEPSI-PMDTGVCIPYHSLWGDIKFEDVSFSYPTRPGHTVFENLTLSIPAGQVVALCG 460

  Fly   467 PSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSR-IGVVGQEPILFATSIYENIRYG 530
            |||.||||...|::|||:|::|.:..:|.:|::|::.|||.: ||::.|||:|||||:.||||||
 Worm   461 PSGEGKSTITHLLERFYEPKSGRVTLDGRDLRELNVEWLRGQVIGLISQEPVLFATSVEENIRYG 525

  Fly   531 REDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDE 595
            |.|||.||:..||.||:...|:.:.|.||.|:|||||||||||||||||||||::::|.||:|||
 Worm   526 RPDATDEEVREAARAAHVDEFVSRFPSGYSTVVGERGAQLSGGQKQRIAIARAILKNPPILILDE 590

  Fly   596 ATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELK 658
            ||||||:.||..||.||..|..|||.:|:||||||:|.|..|.||...:.:|||||::||..|
 Worm   591 ATSALDSHSEHMVQEALNNVMKGRTVLIIAHRLSTIRSAQMIYVIKDKKALESGTHEQLMAKK 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	202/583 (35%)
haf-6	NP_490828.3	MdlB	87..664	CDD:440747	202/583 (35%)