Protein Alignment Mdr50 and ABCB8

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_001269220.1
• Gene: ABCB8 / 11194
• HGNCID: 49
• Length: 735
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 211/599 - (35%)
• Similarity: 313/599 - (52%)
• Gaps: 59/599 - (9%)

  Fly   741 PEWLQIAVG---CISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVREN-------SNQYSLYFL 795
            |..|.:.|.   .:.:.::...:|:   |.|.::::::     :|.|::       |...|.:.|
Human   143 PHLLVLGVAVVLALGAALVNVQIPL---LLGQLVEVVA-----KYTRDHVGSFMTESQNLSTHLL 199

  Fly   796 IAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAV 860
            |...|.|:.||..:......|||:...:|..:|.::|||::.:||  ||.||.|.:||:.|....
Human   200 ILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANKTGQLVSRLTTDVQEF 262

  Fly   861 QGATGQRIGTIVQSISTLALG--IALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAK 923
            :.:....|...::|.:.:| |  ::||| ....|.|:.:..||    |.....|||..   |..|
Human   263 KSSFKLVISQGLRSCTQVA-GCLVSLSM-LSTRLTLLLMVATP----ALMGVGTLMGS---GLRK 318

  Fly   924 TMENCTK-------LAVEVVSNIRTVASLGREEMFHQNYIGML----IPAVEISKRNTHFRGLVY 977
            ....|.:       :|.|.:.|:|||.:...|:...:.|...|    ..|.|:.:....|:||
Human   319 LSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGL-- 381

  Fly   978 GLARSLMFFAYAACMYYGTW-----CVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGV 1037
               .::.|    .||..||.     .|..:.:..||:.....|......|:||.......:.:|:
Human   382 ---SNIAF----NCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGL 439

  Fly  1038 SAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIA 1102
            ||...:|.::...|.|....|.........|.|.|..|.||||.|...:|||...|.:..|:.:|
Human   440 SAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVA 504

  Fly  1103 LVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQ-LGIVSQEPILFDRTIRENI 1166
            |||.||.||:|...|::||||...|..::|..|:|.:..:.||.| :|.:||||:||..||.|||
Human   505 LVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENI 569

  Fly  1167 SYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKI 1231
            .:|  ....:|:|:.:|.:::|.||||.:.|.||:|.:||:|..||||||||:|||||||:.|.:
Human   570 RFG--KLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTV 632

  Fly  1232 MLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLL 1296
            ::|||||||||||||:|||:|||.||.|||.:.||||||||..:..|.|..:|.|.|||.|::||
Human   633 LILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELL 697

  Fly  1297 ANRGLYYTLYKLQS 1310
            ...|||..|.:.|:
Human   698 KKGGLYAELIRRQA 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	210/595 (35%)
ABCB8	NP_001269220.1	MdlB	134..714	CDD:440747	211/599 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	712..735		211/599 (35%)