Protein Alignment Mdr50 and abcb10

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: XP_001343218.3
• Gene: abcb10 / 100003744
• ZFINID: ZDB-GENE-040525-2
• Length: 710
• Species: Danio rerio
• Alignment Length: 631
• Identity: 215/631 - (34%)
• Similarity: 333/631 - (52%)
• Gaps: 61/631 - (9%)

  Fly   709 MVTDEKNKKKKKKKVKDPNE-VKPMLEVMKMNKPEW-LQIAVG--CISSVIMGCAMPIFAVLFGS 769
            :|..|.:.|.....:..|:| ||.:|::  .:...| |..|||  .|||.:...| |.|   .|.
Zfish   100 VVNQESSAKTTADSLPVPSEDVKKLLQL--AHPQRWRLTAAVGFLVISSTVTMSA-PFF---LGK 158

  Fly   770 ILQILSVKDNDQYVRENSNQYSLYFLIAGIVV--GIATFLQIYFFGIAGERLTERLRGLMFEAML 832
            ::..:.....:.:   :|:..||..::.|:.:  |.|...::|...|:|:::..:||..:|.::|
Zfish   159 VIDTIYTSPTEDF---SSSLTSLCLMLTGVFLCGGAANAARVYLMQISGQQIVRKLRESLFSSIL 220

  Fly   833 RQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSL-GLVA 896
            :||:.:||  ...||.|..|||.|.|.|.......:...::|::....|:.:.:|...|| ..|.
Zfish   221 KQELGFFD--KTRTGELINRLSADTAIVGRCLTDNLSDGLRSLAQAGAGVGMMLYVSPSLAAFVL 283

  Fly   897 LAFTPFILIAFYMQRTLMAKENMGSAKTME---NCTKLAVEVVSNIRTVASLGREEMFHQNYIGM 958
            :...|...:|....|.|.:.    |.:|.:   ..|:||.|.:||:|||.:.|:|....|.|...
Zfish   284 MVVPPIACLAVIFGRFLRSI----SRRTQDALAEATQLAEERISNLRTVRAFGKELTEVQKYSQK 344

  Fly   959 LIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYG----TWCVIHRGILF-GDVFKVSQALIM 1018
            :....|::|:.                 |..:..:||    :..||...:|: |.:...|:|:.:
Zfish   345 VDHIFELAKKE-----------------AVVSAGFYGVTGLSGNVIILSVLYKGGLLMASEAMTV 392

  Fly  1019 GT------------ASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVR 1071
            |.            .|||...:|...:.||:.|...::..:.|:|......|:.......:|.:.
Zfish   393 GQLSSFLMYAFWVGISIAGFSSFYSELMKGLGAGTRLWELIDRKPEFPLNEGLVLTSELLKGELE 457

  Fly  1072 FDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDV 1136
            |..|.|:||||.:..:.:.|.|.|..|..:|:||.||.|||:.:.|:.|.||.|.|...:|..|:
Zfish   458 FRNVSFAYPTRKDSPIFQDLSLHVPAGSVLAVVGSSGSGKSSLVSLLLRLYDPDSGIVSVDGHDI 522

  Fly  1137 RNVSMTNLRNQLGIVSQEPILFDRTIRENISYG-DNARNVTDQEIISACKKSNIHEFIANLPLGY 1200
            |:::...||:.:|.|||||:||..:|.|||:|| .:...||.::|..|.:.:|.|:||...|.||
Zfish   523 RDLNPYWLRSHIGTVSQEPVLFSCSIAENIAYGAPDPSQVTVEDIYRAAQIANAHDFIQEFPKGY 587

  Fly  1201 DTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISI 1265
            ||.:||||..||||||||:||||||::||||:||||||||||||:|.:||:||:...:|||.:.|
Zfish   588 DTVVGEKGVLLSGGQKQRVAIARALLKNPKILLLDEATSALDAENEFLVQEALERLMDGRTVLII 652

  Fly  1266 AHRLSTVVHSDVIFVFENGLVCEAGDHKQLLAN-RGLYYTLYKLQS 1310
            ||||||:..:|.:.|.:...|.|.|.|.||||| :||:..|.:.|:
Zfish   653 AHRLSTIQSADSVAVLDQHRVMEIGSHSQLLANDQGLFRKLMEKQA 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	214/627 (34%)
abcb10	XP_001343218.3	MdlB	122..698	CDD:440747	208/607 (34%)