Protein Alignment Opa1 and MX2

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_002454.1
• Gene: MX2 / 4600
• HGNCID: 7533
• Length: 715
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 167/773 - (21%)
• Similarity: 305/773 - (39%)
• Gaps: 166/773 - (21%)

  Fly   211 SDESRKKYEKLQSQVETLQTE-----IMNVQIKYQKELEKMEKENRELRQQYLILKTN------- 263
            |..|.:||  |:.::.:.|.:     .:..|:.:....:..||:...|.:.:..|..|
Human    14 SQFSSRKY--LKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLAKDFNFLTLNNQPPPGN 76

  Fly   264 -KKTTAKKIKKSLIDMYS-------EVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIA 320
             .:..|...:.:|...|.       :::|.|........:|  ||.:.|:|||||||:||||:::
Human    77 RSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLA--LPAIAVIGDQSSGKSSVLEALS 139

  Fly   321 KARIFPRGSGEMMTRAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQD---LRRDVEFRMKASV 382
            ...: ||||| ::||.|:.:.|.:.|......|.|.|..:|    :|||   :.:::........
Human   140 GVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRNTEL----ELQDPGQVEKEIHKAQNVMA 198

  Fly   383 RGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCI 447
            ..|:.:|:|:|::.:..|.:..:.::|||||......:...|....|..:.|.|:.....|.|.:
Human   199 GNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVV 263

  Fly   448 QDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVV 512
            ...:||...:....:..:.||.|.|||.:|||.||.:...:.. :..::....:|:|.  .|.:|
Human   264 VPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMDRGTEKS-VMNVVRNLTYPLKK--GYMIV 325

  Fly   513 TGRGRKDD----SIDAIRQYEEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETI-- 571
            ..||:::.    |:....:.|..||:....|  |.::.....|...|:..::......:::::
Human   326 KCRGQQEITNRLSLAEATKKEITFFQTHPYF--RVLLEEGSATVPRLAERLTTELIMHIQKSLPL 388

  Fly   572 ------------------------EQQADAF-----KATRFNLETEWKNNFPRLRESGRDELFDK 607
                                    .|:||..     |...||.:.|.......:.......|::|
Human   389 LEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRLYNK 453

  Fly   608 AKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESI------YLPAAQSGSQN--SFNTMV 664
            .:.:.            |.|...|:|.. :|:.|.:.|.:      |......|..|  :|..:|
Human   454 IREDF------------KNWVGILATNT-QKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIV 505

  Fly   665 DIKLRQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAV---VDEAIRRHSW 726
            ...::|..|.||  ..::...|.:||.||::      |:.|.|.|..|...|   :::...:|:
Human   506 HQYIQQLVEPAL--SMLQKAMEIIQQAFINV------AKKHFGEFFNLNQTVQSTIEDIKVKHT- 561

  Fly   727 EDKAIDML----RVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQ-MRR 786
             .||.:|:    |:.|:...:|:..               ||..|.|: ||....:..|.| |:.
Human   562 -AKAENMIQLQFRMEQMVFCQDQIY---------------SVVLKKVR-EEIFNPLGTPSQNMKL 609

  Fly   787 ITHWQYLTQDQQKRRSVKN-------------ELDKILKNDTKHLPTLTHDELTTVRKN---LQR 835
            .:|:      .....||.:             |..|.|.|   .:|.:.  :...:|:|   ||:
Human   610 NSHF------PSNESSVSSFTEIGIHLNAYFLETSKRLAN---QIPFII--QYFMLRENGDSLQK 663

  Fly   836 DNVDVDTDYIRQTWFPVYRKHFLQQALQRAKDCR----KAYYLYTQQGAECEISCSDV 889
            ..:.:..:..|.:|       .||:..:.|...|    :.|.|...:.|.|:.|..::
Human   664 AMMQILQEKNRYSW-------LLQEQSETATKRRILKERIYRLTQARHALCQFSSKEI 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	74/306 (24%)
		OPA1_C	629..972	CDD:466080	64/297 (22%)
MX2	NP_002454.1	nuclear localization signal (NLS)	1..24		5/11 (45%)
		DLP_1	116..387	CDD:206738	75/283 (27%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	125..132		6/6 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	150..152		0/1 (0%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	225..228		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	294..297		2/2 (100%)
		Dynamin_M	307..594	CDD:460033	61/329 (19%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	326..329		0/2 (0%)
		GED	621..709	CDD:128597	19/99 (19%)