Protein Alignment Opa1 and DNM3

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_016856465.1
• Gene: DNM3 / 26052
• HGNCID: 29125
• Length: 921
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 92/526 - (17%)
• Similarity: 172/526 - (32%)
• Gaps: 173/526 - (32%)

  Fly    99 IDEMIMKANTVAELLAVSDVTKVNRKQALKIVS------------ILAEWSSIKKVNLSDFE--- 148
            :.|:..||.   |.||.:::.|: |:|..|:|.            |.:::..|:.:.....|
Human    30 LPELSEKAK---EQLAEAELRKL-RQQFRKMVDSRKSSNFRNQRMIASQYKEIENLKAEQAETTL 90

  Fly   149 -------------NDSRFVELCSLLGRTGTQRTAGGARTNAGGPSAKSTELQGD------DLQTV 194
                         |...|.||..||                        :.:||      .::.:
Human    91 LLSLVKSPKNLDLNQKNFTELRFLL------------------------QTKGDYEALISSMKVL 131

  Fly   195 LGITANDEAAKLIAGLTLPQMIKVMSSLA---AKKKRSIPLLR------SLSFN-IASSPGQLNL 249
            || ..:|:..::...:|..:.|.:.:..|   .|.::.|.:|.      ::.|: :.:|..||.
Human   132 LG-ELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNLVTVHFDTMLTSNAQLR- 194

  Fly   250 KECGDLLYAMACLNFRDVVLTGRICADVDRELAKNTDKMAPIVSVLTSLGMLRYRDGAVLDNLCG 314
            |:..|||:..|..:        .:...:.|.|  .|.|....|::..|......|..|:
Human   195 KDIEDLLFEKAAYD--------HVYQQLQRRL--QTQKKTMNVAIEQSTQAYEQRVEAM------ 243

  Fly   315 WIASHHELCKPTQLGSLLLSLATLNYEPISMDTIKAKLVANVSENDFIRSTDWLNTVWSLTILNC 379
                           :.:.::.....:.||...::.:.:..:.:::
Human   244 ---------------ARMAAMKDRQQKDISQYNLEIRELERLYDHE------------------- 274

  Fly   380 VSGEQLSSVLNADFFRRLQDERRGNLQPSMKIKLLNMAAAAKRVPGAKESLLATHRAELFVPFEP 444
               .:|.|.|......|.:.|.:...|.::|||    ....||...:.||....|...|
Human   275 ---NKLKSFLLVKLNDRTEFEDQAKKQEAVKIK----KHGKKRKGESFESYEVAHLRLL------ 326

  Fly   445 SKDKRVLVTGMLDALKSLIPSESMVKISQTTTMGFTIDAECVLDKKCLPLPVDKEHEQGTRIALL 509
                ::...|.|:.|     :|..:...:.....||...|...|.:.:       |::..||...
Human   327 ----KLAENGDLNQL-----TEDFLAKEEKNFARFTYVTELNNDMETM-------HKRTQRIQDD 375

  Fly   510 VHDYHDMCQGPHVALNGIQALNMRLLEQ------EGYTVLSIPYNEFSTSDKLLKRVEYL----Q 564
            :.:.....|..|.....|    ::.:|:      |...:....|.|.|      |.:|||    :
Human   376 IINLRSQQQSSHEGTRNI----LKQMEEKLRKTTEDTDIYENRYREMS------KTLEYLKNSVE 430

  Fly   565 KKFKSI 570
            |.||.|
Human   431 KLFKKI 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	46/283 (16%)
		OPA1_C	629..972	CDD:466080
DNM3	XP_016856465.1	DYNc	6..245	CDD:197491	48/275 (17%)
		Dynamin_M	215..502	CDD:460033	52/303 (17%)
		PH_dynamin	526..683	CDD:269958
		GED	707..797	CDD:460495
		PHA03247	<806..893	CDD:223021